ORIGINAL ARTICLE Recombinant ADAMTS13 in Congenital Thrombotic Thrombocytopenic Purpura Authors: Marie Scully, Ana Antun, Spero R. Cataland, et al N Engl J Med 2024;390:1584-1596 DOI: 10.1056/NEJMoa2314793 Abstract BACKGROUND Congenital thrombotic thrombocytopenic purpura (TTP) results from severe hereditary deficiency of ADAMTS13. The efficacy and safety of recombinant ADAMTS13 and standard therapy (plasma-derived products) administered as routine pr...

Critical Care: Original Research Prospective Evaluation of Venous Excess Ultrasound for Estimation of Venous Congestion August Longino, Katie Martin, Katarina Leyba, et al Chest 2024; 165: 590-600 https://doi.org/10.1016/j.chest.2023.09.029 Background Venous excess ultrasound (VExUS) is a novel ultrasound technique previously reported as a noninvasive measure of venous congestion and predictor of cardiorenal acute kidney injury. ...

Chest Infections: Original Research Prevalence, Risk Factors, Clinical Features, and Outcome of Influenza-Associated Pulmonary Aspergillosis in Critically Ill Patients: A Systematic Review and Meta-Analysis Lawrence Y. Lu, Hui Min Lee, Andrew Burke, et al Chest 2024; 165: 540-558 https://doi.org/10.1016/j.chest.2023.09.019 Background Influenza-associated pulmonary aspergillosis (IAPA) increasingly is being reported in critically ill patients. We conducte...

Chest Infections: Original Research Legionnaires Disease in Solid Organ Transplant Recipients: A Decade-Long Nationwide Study in France Guillaume Thizy, Adrien Flahault, Anne Scemla, et al Chest 2024; 165: 507-520 https://doi.org/10.1016/j.chest.2023.09.033 Background Legionnaires disease (LD) is a rare, life-threatening opportunistic bacterial infection that poses a significant risk to patients with impaired cell-mediated immunity such as solid organ tr...

Original Investigation  Nephrology March 8, 2024 Recovery Dynamics and Prognosis After Dialysis for Acute Kidney Injury Heng-Chih Pan, Hsing-Yu Chen, Nai-Chi Teng, et al JAMA Netw Open. 2024;7(3):e240351. doi:10.1001/jamanetworkopen.2024.0351 Key Points Question  Are baseline kidney function, acute kidney disease (AKD) severity, and post-AKD kidney function associated with adverse outcomes in...

ARTICLES| VOLUME 5, ISSUE 3, E235-E246, MARCH 2024 SARS-CoV-2 shedding and evolution in patients who were immunocompromised during the omicron period: a multicentre, prospective analysis Zoe Raglow, Diya Surie, James D Chappell, et al Lancet Microbe 2024; 5: E235-E246 Published: January 26, 2024 DOI: https://doi.org/10.1016/S2666-5247(23)00336-1 Summary Background Prolonged SARS-CoV-2 infections in people who are immunocompromised might predict or sou...

ARTICLES| VOLUME 5, ISSUE 3, E247-E260, MARCH 2024Download Full Issue Lower respiratory tract single-cell RNA sequencing and neutrophil extracellular trap profiling of COVID-19-associated pulmonary aspergillosis: a single centre, retrospective, observational study Simon Feys, Sam Vanmassenhove, Sirima Kraisin, et al Lancet Microbe 2024; 5: E247-E260 Published:January 24, 2024 DOI: https://doi.org/10.1016/S2666-5247(23)00368-3 Summary Background COVID-...

Original Investigation  Infectious Diseases March 4, 2024 Propensity Score-Weighted Analysis of Postoperative Infection in Patients With and Without Preoperative Urine Culture William J. O’Brien, Marin L. Schweizer, Judith Strymish, et al JAMA Netw Open. 2024;7(3):e240900. doi:10.1001/jamanetworkopen.2024.0900 Key Points Question  Is the practice of preoperative urine culture associated with reduced risk of postoperative urina...

Original Investigation  Infectious Diseases March 6, 2024 Diagnostic Stewardship in Community-Acquired Pneumonia With Syndromic Molecular Testing: A Randomized Clinical Trial Dagfinn L. Markussen, Sondre Serigstad, Christian Ritz, et al JAMA Netw Open. 2024;7(3):e240830. doi:10.1001/jamanetworkopen.2024.0830 Key Points Question  Does the judicious use of a syndromic polymerase chain reaction (PCR)-based panel for rapid testing...

Original Investigation  Less Is More March 4, 2024 Clinical Outcomes of Rapid Respiratory Virus Testing in Emergency Departments: A Systematic Review and Meta-Analysis Tilmann Schober, Kimberly Wong, Gaëlle DeLisle, et al JAMA Intern Med. Published online March 4, 2024. doi:10.1001/jamainternmed.2024.0037 Key Points Question  Is rapid testing for respiratory viruses associated with patient treatment in the emergency department...