Original Investigation  Public Health January 19, 2024 Occupational Sitting Time, Leisure Physical Activity, and All-Cause and Cardiovascular Disease Mortality Wayne Gao, Mattia Sanna, Yea-Hung Chen, et al JAMA Netw Open. 2024;7(1):e2350680. doi:10.1001/jamanetworkopen.2023.50680 Key Points Question  What are the health outcomes associated with prolonged occupational sitting in the context of various levels of physical activit...

ARTICLES| VOLUME 12, ISSUE 2, E201-E216, FEBRUARY 2024 The burden of bacterial antimicrobial resistance in the WHO African region in 2019: a cross-country systematic analysis Antimicrobial Resistance Collaborators Lancet Glob Health 2024; 12: E201-E216 Published: December 19, 2023 DOI:https://doi.org/10.1016/S2214-109X(23)00539-9 Summary Background A critical and persistent challenge to global health and modern health care is the threat of antimicrobial ...

Research 25 year trends in cancer incidence and mortality among adults aged 35-69 years in the UK, 1993-2018: retrospective secondary analysis Jon Shelton, Ewa Zotow, Lesley Smith, et al BMJ 2024; 384 doi: https://doi.org/10.1136/bmj-2023-076962 (Published 13 March 2024)Cite this as: BMJ 2024;384:e076962 Abstract Objective To examine and interpret trends in UK cancer incidence and mortality for all cancers combined and for the most common cancer sites ...

Original Investigation  Cardiology February 1, 2024 Differential Associations of Alcohol Use With Ischemic Heart Disease Mortality by Socioeconomic Status in the US, 1997-2018 Yachen Zhu, Laura Llamosas-Falcón, William Kerr, et al JAMA Netw Open. 2024;7(2):e2354270. doi:10.1001/jamanetworkopen.2023.54270 Key Points Question  Does socioeconomic status (SES) modify the association of alcohol use with ischemic heart disease (IHD)...

Original Investigation  March 13, 2024 Accreditation Council for Graduate Medical Education Milestone Training Ratings and Surgeons’ Early Outcomes Brigitte K. Smith, Kenji Yamazaki, Ara Tekian, et al JAMA Surg. Published online March 13, 2024. doi:10.1001/jamasurg.2024.0040 Key Points Question  Does assessment of surgical competence using Accreditation Council for Graduate Medical Education Milestones during training predict fut...

Original Investigation  Infectious Diseases March 13, 2024 Bacteremia From a Presumed Urinary Source in Hospitalized Adults With Asymptomatic Bacteriuria Sonali D. Advani, David Ratz, Jennifer K. Horowitz, et al JAMA Netw Open. 2024;7(3):e242283. doi:10.1001/jamanetworkopen.2024.2283 Key Points Question  What is the prevalence of bacteremia from a presumed urinary source in hospitalized patients with asymptomatic bacteriuria (...

Original Investigation  Surgery February 2, 2024 Risk of Venous Thromboembolic Events After Surgery for Cancer Johan Björklund, Juhana Rautiola, Renata Zelic, et al JAMA Netw Open. 2024;7(2):e2354352. doi:10.1001/jamanetworkopen.2023.54352 Key Points Question  Is major cancer surgery associated with an increased risk of venous thromboembolism after surgery? Findings  This population-based nationwide cohort study c...

ORIGINAL ARTICLE Oral Iptacopan Monotherapy in Paroxysmal Nocturnal Hemoglobinuria Régis Peffault de Latour, Alexander Röth, Austin G. Kulasekararaj, et al N Engl J Med 2024; 390:994-1008DOI: 10.1056/NEJMoa2308695 Abstract BACKGROUND Persistent hemolytic anemia and a lack of oral treatments are challenges for patients with paroxysmal nocturnal hemoglobinuria who have received anti-C5 therapy or have not received complement inhibitors. Iptacopan, a first-...

Chest Infections: Original Research Using Trajectories of Bedside Vital Signs to Identify COVID-19 Subphenotypes Sivasubramanium V. Bhavani, Chad Robichaux, Philip A. Verhoef, et al Chest 2024; 165: 529-539 https://doi.org/10.1016/j.chest.2023.09.020 Background Trajectories of bedside vital signs have been used to identify sepsis subphenotypes with distinct outcomes and treatment responses. The objective of this study was to validate the vitals trajector...

Critical Care: Original Research Changes in Respiratory Mechanics With Trunk Inclination Differs Between Patients With ARDS With and Without Obesity Shailesh Bihari, Ubbo F. Wiersema Chest 2024; 165: 583-589 https://doi.org/10.1016/j.chest.2023.09.032 Background Studies investigating the effect of trunk inclination on respiratory mechanics in mechanically ventilated patients with ARDS have reported postural differences in partition respiratory ...