Original Investigation  March 25, 2024 Effectiveness of an Artificial Intelligence–Enabled Intervention for Detecting Clinical Deterioration Robert J. Gallo, Lisa Shieh, Margaret Smith, et al JAMA Intern Med. Published online March 25, 2024. doi:10.1001/jamainternmed.2024.0084 Key Points Question  Is an artificial intelligence (AI) deterioration model–enabled intervention associated with a decre...

Original Investigation  Critical Care Medicine February 6, 2024 Early Sepsis-Associated Acute Kidney Injury and Obesity Yoon Hae Ahn, Si Mong Yoon, Jinwoo Lee, et al JAMA Netw Open. 2024;7(2):e2354923. doi:10.1001/jamanetworkopen.2023.54923 Key Points Question  In critically ill patients with sepsis, is obesity associated with incidence of early sepsis-associated acute kidney injury (SA-AKI)? Findings  In this ...

Original Investigation  Caring for the Critically Ill Patient May 19, 2024 Acetaminophen for Prevention and Treatment of Organ Dysfunction in Critically Ill Patients With Sepsis: The ASTER Randomized Clinical Trial Lorraine B. Ware, D. Clark Files, Alpha Fowler, et al JAMA. Published online May 19, 2024. doi:10.1001/jama.2024.8772 Key Points Question  Does acetaminophen (paracetamol) improve respiratory, circulatory, or kidney...

Routine Metagenomics Service for ICU Patients with Respiratory Infection Themoula Charalampous,  Adela Alcolea-Medina,  Luke B. Snell, et al Am J Respir Crit Care Med 2024; 209; 164-174 DOI: https://doi.org/10.1164/rccm.202305-0901OC  Abstract Rationale: Respiratory metagenomics (RMg) needs evaluation in a pilot service setting to determine utility and inform implementation into routine clinical practice. Objectives: Feasibility, performance, a...

ARTICLES| VOLUME 12, ISSUE 2, E235-E242, FEBRUARY 2024 Routine sterile glove and instrument change at the time of abdominal wound closure to prevent surgical site infection (ChEETAh): a model-based cost-effectiveness analysis of a pragmatic, cluster-randomised trial in seven low-income and middle-income countries NIHR Global Health Research Unit on Global Surgery Lancet Glob Health Published: February, 2024 DOI:https://doi.org/10.1016/S2214-109X(23)00538-7 ...

Original Investigation  February 6, 2024 Effectiveness of Bivalent mRNA COVID-19 Vaccines in Preventing SARS-CoV-2 Infection in Children and Adolescents Aged 5 to 17 Years Leora R. Feldstein, Amadea Britton, Lauren Grant, et al JAMA. 2024;331(5):408-416. doi:10.1001/jama.2023.27022 Key Points Question  What is the effectiveness of the bivalent COVID-19 vaccines among children and adolescents aged 5 to 17 years? Findings &...

Original Investigation  Infectious Diseases February 27, 2024 Female Sex and Mortality in Patients with Staphylococcus aureus Bacteremia: A Systematic Review and Meta-analysis Annette C. Westgeest, Merel M. C. Lambregts, Felicia Ruffin, et al JAMA Netw Open. 2024;7(2):e240473. doi:10.1001/jamanetworkopen.2024.0473 Key Points Question  Is female sex associated with increased mortality risk in patients with Staphylococcus a...

Research Letter  March 18, 2024 Comparative Analysis of Multimodal Large Language Model Performance on Clinical Vignette Questions Tianyu Han, Lisa C. Adams, Keno K. Bressem, et al JAMA. Published online March 18, 2024. doi:10.1001/jama.2023.27861 Large language models (LLMs) have attracted attention for their ability to process text and other complex content.1,2 In medicine, an LLM-based advisory chat agent could assist in research, educatio...

Original Investigation  March 19, 2024 Stroke Risk After COVID-19 Bivalent Vaccination Among US Older Adults Yun Lu, Kathryn Matuska, Gita Nadimpalli, et al JAMA. 2024;331(11):938-950. doi:10.1001/jama.2024.1059 Key Points Question  Among adults aged 65 years or older, is the risk of stroke elevated in a time period immediately after administration of either brand of a COVID-19 bivalent vaccine compared with a later time period? ...

Original Investigation  March 18, 2024 Video Laryngoscopy vs Direct Laryngoscopy for Endotracheal Intubation in the Operating Room: A Cluster Randomized Clinical Trial Kurt Ruetzler, Sergio Bustamante, Marc T. Schmidt, et al JAMA. Published online March 18, 2024. doi:10.1001/jama.2024.0762 Key Points Question  What is the effect of initial video laryngoscopy or direct laryngoscopy on number of intubation attempts in patients bein...