ARTICLES|ONLINE FIRST The first WHO global survey on infection prevention and control in health-care facilities Sara Tomczyk, Anthony Twyman, Marlieke E A de Kraker, et al Lancet Infect Dis Published: February 21, 2022 DOI:https://doi.org/10.1016/S1473-3099(21)00809-4 Summary Background WHO core components for infection prevention and control (IPC) are important building blocks for effective IPC programmes. To our knowledge, we did the first WHO globa...

ARTICLES|ONLINE FIRST High-flow nasal oxygen alone or alternating with non-invasive ventilation in critically ill immunocompromised patients with acute respiratory failure: a randomised controlled trial Rémi Coudroy, Jean-Pierre Frat, Stephan Ehrmann, et al Lancet Respir Med Published:March 21, 2022 DOI:https://doi.org/10.1016/S2213-2600(22)00096-0 Summary Background Although non-invasive ventilation (NIV) is recommended for immunocompromised patients...

ARTICLES|ONLINE FIRST Implementation of hand hygiene in health-care facilities: results from the WHO Hand Hygiene Self-Assessment Framework global survey 2019 Marlieke E A de Kraker, Ermira Tartari, Sara Tomczyk, et al Lancet Infect Dis Published: February 21, 2022 DOI:https://doi.org/10.1016/S1473-3099(21)00618-6 Summary Background Hand hygiene is at the core of effective infection prevention and control (IPC) programmes. 10 years after the developme...

Research Letter April 8, 2022 Systemic Corticosteroid Use for COVID-19 in US Outpatient Settings From April 2020 to August 2021 Marie C. Bradley, Silvia Perez-Vilar, Yoganand Chillarige, et al JAMA. Published online April 8, 2022. doi:10.1001/jama.2022.4877 In June 2020, preliminary results for the Randomised Evaluation of COVID-19 Therapy (RECOVERY) trial conducted in the UK indicated benefit from dexamethasone in severely ill hospitalized pati...

Original Investigation Caring for the Critically Ill PatientFebruary 18, 2022 Association of COVID-19 Acute Respiratory Distress Syndrome With Symptoms of Posttraumatic Stress Disorder in Family Members After ICU Discharge Elie Azoulay, Matthieu Resche-Rigon, Bruno Megarbane, et al JAMA. Published online February 18, 2022. doi:10.1001/jama.2022.2017 Key Points Question  Is the risk of posttraumatic stress disorder (PTSD) symptoms in...

ARTICLES|ONLINE FIRST Screening and vaccination against COVID-19 to minimise school closure: a modelling study Elisabetta Colosi, Giulia Bassignana, Diego Andrés Contreras, et al Lancet Infect Dis Published:April 01, 2022 DOI:https://doi.org/10.1016/S1473-3099(22)00138-4 Summary Background Schools were closed extensively in 2020–21 to counter SARS-CoV-2 spread, impacting students' education and wellbeing. With highly contagious variants expanding in E...

Original Investigation Caring for the Critically Ill PatientFebruary 22, 2022 Effect of Intra-arrest Transport, Extracorporeal Cardiopulmonary Resuscitation, and Immediate Invasive Assessment and Treatment on Functional Neurologic Outcome in Refractory Out-of-Hospital Cardiac Arrest: A Randomized Clinical Trial Jan Belohlavek, Jana Smalcova, Daniel Rob, et al JAMA. 2022;327(8):737-747. doi:10.1001/jama.2022.1025 Key Points Question  ...

Original Investigation March 24, 2022 Association of COVID-19 Vaccination in Pregnancy With Adverse Peripartum Outcomes Deshayne B. Fell, Tavleen Dhinsa, Gillian D. Alton, et al JAMA. 2022;327(15):1478-1487. doi:10.1001/jama.2022.4255 Key Points Question  Is COVID-19 vaccination during pregnancy associated with adverse peripartum outcomes? Findings  In this population-based retrospective cohort study of 97 590 individuals in Onta...

ARTICLES| VOLUME 10, ISSUE 4, P355-366, APRIL 01, 2022 SARS-CoV-2 infection and vaccine effectiveness in England (REACT-1): a series of cross-sectional random community surveys Marc Chadeau-Hyam, Haowei Wang, Oliver Eales, et al Lancet Respir Med 2022; 10: 355-366 Summary Background England has experienced a third wave of the COVID-19 epidemic since the end of May, 2021, coinciding with the rapid spread of the delta (B.1.617.2) variant, de...

Original Investigation March 24, 2022 Association of SARS-CoV-2 Vaccination During Pregnancy With Pregnancy Outcomes Maria C. Magnus, Anne K. Örtqvist, Elisabeth Dahlqwist, et al JAMA. 2022;327(15):1469-1477. doi:10.1001/jama.2022.3271 Key Points Questions  Is SARS-CoV-2 vaccination during pregnancy associated with adverse pregnancy outcomes? Findings  In this population-based retrospective cohort study that included 157 521 deli...