Original Investigation  Pediatrics Adverse Events Following Short-Course Systemic Corticosteroids Among Children and Adolescents: A Systematic Review and Meta-Analysis João Pedro Lima, Saifur R. Chowdhury, Wimonchat Tangamornsuksan, et al JAMA Netw Open 2025;8;(9):e2534953. doi:10.1001/jamanetworkopen.2025.34953 Key Points Question  What adverse events are associated with the use of systemic corticosteroi...

Original Investigation  Medical Education Variation in Research Experiences and Publications During Medical School by Sex and Race and Ethnicity Mytien Nguyen, Sarwat I. Chaudhry, Emmanuella Asabor, et al JAMA Netw Open 2022;5;(10):e2238520. doi:10.1001/jamanetworkopen.2022.38520 Key Points Question  Are student sex and racial and ethnic identity associated with publication rate during medical school? ...

Original Investigation  Emergency Medicine In-Flight Medical Events on Commercial Airline Flights Paulo M. Alves, Karan R. Kumar, Justin Devlin, et al JAMA Netw Open 2025;8;(9):e2533934. doi:10.1001/jamanetworkopen.2025.33934 Key Points Question  What are the characteristics of in-flight medical events on commercial airline flights and the factors associated with aircraft diversion, hospital transport, an...

Research Letter  Pacific Coast Surgical Association Hospital Market Competition, Morbidity, and Resource Utilization Following Elective Cancer Resection Sara Sakowitz, Syed Shahyan Bakhtiyar, Nicholas S. Siena, et al JAMA Surg Published Online: October 1, 2025 doi: 10.1001/jamasurg.2025.3643 Over the past decade, health system mergers and expansions, along with evidence supporting the volume-outcome relat...

Original Investigation  Early Intratracheal Budesonide to Reduce Bronchopulmonary Dysplasia in Extremely Preterm Infants: The Budesonide in Babies (BiB) Randomized Clinical Trial Namasivayam Ambalavanan, Waldemar A. Carlo, Kayla J. Nowak, et al JAMA Published Online: September 30, 2025 doi: 10.1001/jama.2025.16450 Key Points Question  Does intratracheal administration of budesonide mixed with su...

Monocyte HLA-DR expression in septic shock patients: insights from a 20-year real-world cohort of 1023 cases Monneret G, Lafon T, Gossez M, et al. Intensive Care Med(2025). https://doi.org/10.1007/s00134-025-08110-w Abstract Purpose Septic patients simultaneously experience hyperinflammation and immunosuppression, the latter driving ICU-acquired infections, prolonged stays in ICU, and increased mortality. As immunostimulant therapies enter clinical trials, ...

ONLINE FIRST (FREE ACCESS) STANDARD OF CARE IN THE INTENSIVE CARE UNIT What's New in Intensive Care Short piece: metabolic acidosisJung, B., Forni, L.G. & Jaber, S. Narrative Review Bedside thoracic echography in ICU: new insights for acute circulatory and respiratory failureMuller, L., Volpicelli, G., Mongodi, S. et al. Editorial Best practices in airway management in critically ill adultsDe Jong, A., Jaber, S. & Myatra, S.N. LATEST ARTICL...

Original Investigation  AI in Medicine An AI-Powered Lifestyle Intervention vs Human Coaching in the Diabetes Prevention Program: A Randomized Clinical Trial Nestoras Mathioudakis, Benjamin Lalani, Mohammed S. Abusamaan, et al JAMA Published Online: October 27, 2025 doi: 10.1001/jama.2025.19563 Key Points Question  How does referral to a lifestyle intervention exclusively driven by artificial...

Original Investigation  Critical Care Medicine Awake Prone Positioning in Patients With COVID-19 Respiratory Failure: A Randomized Clinical Trial Anatole Harrois, Romain Jouffroy, Soufia Ayed, et al JAMA Netw Open 2025;8;(12):e2548201. doi:10.1001/jamanetworkopen.2025.48201 Key Points Question  What are the effects of awake prone positioning on the incidence of intubation and/or death in nonintubated pati...

Original Investigation  Implications of Changing Institutions for Promotion in Academic Surgery Isabelle M. C. Tan, Haley Harris, Yuqing Qiu, et al JAMA Surg Published Online: December 10, 2025 doi: 10.1001/jamasurg.2025.5490 Key Points Question  Does changing institutions impact academic promotion pathways for academic surgeons? Findings  In this cohort study of 6321 surgical facul...