ORIGINAL ARTICLE Efficacy and Safety of a Recombinant Plant-Based Adjuvanted Covid-19 Vaccine Karen J. Hager, Gonzalo Pérez Marc, Philipe Gobeil, et al N Engl J Med May 4, 2022DOI: 10.1056/NEJMoa2201300 Abstract BACKGROUND Coronavirus-like particles (CoVLP) that are produced in plants and display the prefusion spike glycoprotein of the original strain of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are combined with an adjuvant (Adjuvant ...

ORIGINAL ARTICLE Single-Dose Liposomal Amphotericin B Treatment for Cryptococcal Meningitis Joseph N. Jarvis, David S. Lawrence, David B. Meya, et al N Engl J Med 2022; 386:1109-1120DOI: 10.1056/NEJMoa2111904 Abstract BACKGROUND Cryptococcal meningitis is a leading cause of human immunodeficiency virus (HIV)–related death in sub-Saharan Africa. Whether a treatment regimen that includes a single high dose of liposomal amphotericin B would be efficacious i...

ORIGINAL ARTICLE Efficacy and Safety of the RBD-Dimer–Based Covid-19 Vaccine ZF2001 in Adults Lianpan Dai, Lidong Gao, Lifeng Tao, et al N Engl J Med May 4, 2022DOI: 10.1056/NEJMoa2202261 Abstract BACKGROUND The ZF2001 vaccine, which contains a dimeric form of the receptor-binding domain of severe acute respiratory syndrome coronavirus 2 and aluminum hydroxide as an adjuvant, was shown to be safe, with an acceptable side-effect profile, and immunogenic i...

Original Investigation May 2, 2022 Association of SARS-CoV-2 Infection During Pregnancy With Maternal and Perinatal Outcomes Elisabeth McClymont, Arianne Y. Albert, Gillian D. Alton, et al JAMA. Published online May 2, 2022. doi:10.1001/jama.2022.5906 Key Points Question  Is SARS-CoV-2 infection during pregnancy associated with increased risk of adverse maternal and perinatal outcomes? Findings  This Canadian surveillan...

ORIGINAL ARTICLE Restriction of Intravenous Fluid in ICU Patients with Septic Shock T.S. Meyhoff, P.B. Hjortrup, J. Wetterslev, et al N Engl J Med June 17, 2022DOI: 10.1056/NEJMoa2202707 BACKGROUND Intravenous fluids are recommended for the treatment of patients who are in septic shock, but higher fluid volumes have been associated with harm in patients who are in the intensive care unit (ICU). METHODS In this international, randomized trial, we ...

Original Investigation May 5, 2022 Association Between Use of a Flying Intervention Team vs Patient Interhospital Transfer and Time to Endovascular Thrombectomy Among Patients With Acute Ischemic Stroke in Nonurban Germany Gordian J. Hubert, Nikolai D. Hubert, Christian Maegerlein, et al JAMA. 2022;327(18):1795-1805. doi:10.1001/jama.2022.5948 Key Points Question  In a nonurban region in Germany, is the deployment of a flying intervention tea...

Original Investigation Caring for the Critically Ill PatientMarch 22, 2022 Effect of Antiplatelet Therapy on Survival and Organ Support–Free Days in Critically Ill Patients With COVID-19: A Randomized Clinical Trial REMAP-CAP Writing Committee for the REMAP-CAP Investigators JAMA. Published online March 22, 2022. doi:10.1001/jama.2022.2910 Key Points Question  Does antiplatelet therapy administered to critically ill patients with CO...

ARTICLES| VOLUME 4, ISSUE 3, E177-E187, MARCH 01, 2022 Humoral and cellular immune responses to two and three doses of SARS-CoV-2 vaccines in rituximab-treated patients with rheumatoid arthritis: a prospective, cohort study Ingrid Jyssum, Hassen Kared, Trung T Tran, et al Lancet Rheumatol 2022; 4: e177-e187 Summary Background In rituximab-treated patients with rheumatoid arthritis, humoral and cellular immune responses after two or three d...

Original Investigation  June 16, 2022 Effect of Fluid Bolus Administration on Cardiovascular Collapse Among Critically Ill Patients Undergoing Tracheal Intubation: A Randomized Clinical Trial Derek W. Russell, Jonathan D. Casey, Kevin W. Gibbs, et al JAMA. Published online June 16, 2022. doi:10.1001/jama.2022.9792 Key Points Question  In critically ill adult patients undergoing tracheal intubation, does intravenous infusion of a ...

Original Investigation May 5, 2022 Effect of Direct Transportation to Thrombectomy-Capable Center vs Local Stroke Center on Neurological Outcomes in Patients With Suspected Large-Vessel Occlusion Stroke in Nonurban Areas: The RACECAT Randomized Clinical Trial Natalia Pérez de la Ossa, Sònia Abilleira, Tudor G. Jovin, et al JAMA. 2022;327(18):1782-1794. doi:10.1001/jama.2022.4404 Key Points Question  In patients experiencing suspected large-ve...