ARTICLES|ONLINE FIRST Carbapenem use in extended-spectrum cephalosporin-resistant Enterobacterales infections in US hospitals and influence of IDSA guidance: a retrospective cohort study Morgan K Walker, Guoqing Diao, Sarah Warner, et al Lancet Infect Dis Published: April 25, 2024 DOI: https://doi.org/10.1016/S1473-3099(24)00149-X Summary Background Disparate and rapidly changing practice recommendations from major professional infectious diseases soc...

Blood culture-free ultra-rapid antimicrobial susceptibility testing. Kim, T.H., Kang, J., Jang, H. et al. Nature (2024). https://doi.org/10.1038/s41586-024-07725-1 Abstract Treatment assessment and patient outcome for sepsis depend predominantly on the timely administration of appropriate antibiotics1,2,3. However, the clinical protocols used to stratify and select patient-specific optimal therapy are extremely slow4. In particular, the major hurdle in perform...

ARTICLES|ONLINE FIRST Effectiveness of ferritin-guided donation intervals in whole-blood donors in the Netherlands (FIND'EM): a stepped-wedge cluster-randomised trial Amber Meulenbeld, Steven Ramondt, Maike G Sweegers, et al Lancet Published: June 13, 2024 DOI: https://doi.org/10.1016/S0140-6736(24)01085-7 Summary Background Whole-blood donors are at increased risk for iron deficiency and anaemia. The current standard of haemoglobin monitoring is insu...

Original Investigation  April 3, 2024 Disparities in Mentorship and Implications for US Surgical Resident Education and Wellness Casey M. Silver, Tarik K. Yuce, Callisia N. Clarke, et al JAMA Surg. 2024;159(6):687-695. doi:10.1001/jamasurg.2024.0533 Key Points Question  What resident characteristics are associated with report of meaningful mentorship, and what is the association between mentorship and res...

ARTICLES| VOLUME 404, ISSUE 10453, P670-682, AUGUST 17, 2024 Hypothermic oxygenated perfusion of the donor heart in heart transplantation: the short-term outcome from a randomised, controlled, open-label, multicentre clinical trial Filip Rega, Guillaume Lebreton, Marylou Para, et al Lancet 2024; 404: 670-682 Published:August 17, 2024 DOI: https://doi.org/10.1016/S0140-6736(24)01078-X Summary Background Static cold storage (SCS) remains the gold standa...

ARTICLES| VOLUME 404, ISSUE 10453, P659-669, AUGUST 17, 2024 Effect of high versus standard protein provision on functional recovery in people with critical illness (PRECISe): an investigator-initiated, double-blinded, multicentre, parallel-group, randomised controlled trial in Belgium and the Netherlands Julia L M Bels, Steven Thiessen, Rob J J van Gassel, et al Lancet 2024; 404: 659-669 Published: August 17, 2024 DOI:https://doi.org/10.1016/S0140-6736(24)013...

Research Letter  Geriatrics June 11, 2024 Boarding Duration in the Emergency Department and Inpatient Delirium and Severe Agitation Joshua W. Joseph, Noémie Elhadad, Melissa L.P. Mattison, et al JAMA Netw Open. 2024;7(6):e2416343. doi:10.1001/jamanetworkopen.2024.16343 Introduction Recent studies have demonstrated that emergency department (ED) boarding (ie, holding admitted patients in the ED while...

Original Investigation  Diabetes and Endocrinology June 12, 2024 Limosilactobacillus reuteri 6475 and Prevention of Early Postmenopausal Bone Loss: A Randomized Clinical Trial Giulia Gregori, Aldina Pivodic, Per Magnusson, et al JAMA Netw Open. 2024;7(6):e2415455. doi:10.1001/jamanetworkopen.2024.15455 Key Points Question  Can daily supplementation with the probiotic Limosilactob...

Education and Clinical Practice: Original Research Creation and Validation of a Massive Hemoptysis Simulator Melissa L. New, Timothy Amass, Anna Neumeier, et al Chest 2024; 165: 636-644 https://doi.org/10.1016/j.chest.2023.10.014 Background Simulation for the management of massive hemoptysis is limited by the absence of a commercially available simulator to practice procedural skills necessary for management. Research Question Is it feasi...

ARTICLES|ONLINE FIRST Global burden of 288 causes of death and life expectancy decomposition in 204 countries and territories and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021 GBD 2021 Causes of Death Collaborators Lancet Open Access Published: April 03, 2024 DOI: https://doi.org/10.1016/S0140-6736(24)00367-2 Summary Background Regular, detailed reporting on population health by underlying caus...