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Original Investigation May 15, 2022
Effect of Robot-Assisted Radical Cystectomy With Intracorporeal Urinary Diversion vs Open Radical Cystectomy on 90-Day Morbidity and Mortality Among Patients With Bladder Cancer: A Randomized Clinical Trial
James W. F. Catto, Pramit Khetrapal, Federico Ricciardi, et al
JAMA. Published online May 15, 2022. doi:10.1001/jama.2022.7393
Key Points
Question Does robot-assisted surgery improve periopera...
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CORRESPONDENCE
Omicron BA.1/1.1 SARS-CoV-2 Infection among Vaccinated Canadian Adults
Patrick E. Brown, Sze Hang Fu, Aiyush Bansal, et al
N Engl J Med May 18, 2022DOI: 10.1056/NEJMc2202879
TO THE EDITOR:
The incidence of the omicron BA.1/1.1 variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which rapidly spread worldwide even among vaccinated persons, is incompletely defined.1 We quantified the incidence of SARS-CoV-2 infection d...
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ARTICLES|ONLINE FIRST
Alcoholic chlorhexidine skin preparation or triclosan-coated sutures to reduce surgical site infection: a systematic review and meta-analysis of high-quality randomised controlled trials
National Institute of Health Research Unit on Global Surgery
Lancet Infect Dis Published:May 26, 2022
DOI:https://doi.org/10.1016/S1473-3099(22)00133-5
Summary
Background
WHO and the UK's National Institute for Health and Care Excellence recommen...
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ORIGINAL ARTICLE
Protection and Waning of Natural and Hybrid Immunity to SARS-CoV-2
Yair Goldberg, Micha Mandel, Yinon M. Bar-On, et al
N Engl J Med May 25, 2022DOI: 10.1056/NEJMoa2118946
Abstract
BACKGROUND
Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) provides natural immunity against reinfection. Recent studies have shown waning of the immunity provided by the BNT162b2 vaccine. The time course of natural and hybrid immuni...
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ARTICLES|ONLINE FIRST
Global impact of the first year of COVID-19 vaccination: a mathematical modelling study
Oliver J Watson, Gregory Barnsley, Jaspreet Toor, et al
Lancet Infect Dis Published:June 23, 2022
DOI: https://doi.org/10.1016/S1473-3099(22)00320-6
Summary
Background
The first COVID-19 vaccine outside a clinical trial setting was administered on Dec 8, 2020. To ensure global vaccine equity, vaccine targets were set by the COVID-19 Vaccines G...
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Original Investigation May 17, 2022
Effect of Oral Methylprednisolone on Decline in Kidney Function or Kidney Failure in Patients With IgA Nephropathy: The TESTING Randomized Clinical Trial
Jicheng Lv, Muh Geot Wong, Michelle A. Hladunewich, et al
JAMA. 2022;327(19):1888-1898. doi:10.1001/jama.2022.5368
Key Points
Question What are the effects of oral glucocorticoids in patients with IgA nephropathy and proteinuria of 1 g per day o...
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CORRESPONDENCE
Effectiveness of Homologous and Heterologous Covid-19 Boosters against Omicron
Emma K. Accorsi, Amadea Britton, Nong Shang, et al
N Engl J Med May 25, 2022DOI: 10.1056/NEJMc2203165
TO THE EDITOR:
For persons who received a single dose of the Ad26.COV2.S vaccine (Johnson & Johnson–Janssen) against coronavirus disease 2019 (Covid-19), a booster dose of a messenger RNA (mRNA) vaccine at least 2 months after the primary dose is recommended. R...
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ARTICLES|ONLINE FIRST
Demographic and clinical characteristics of confirmed human monkeypox virus cases in individuals attending a sexual health centre in London, UK: an observational analysis
Nicolò Girometti, Ruth Byrne, Margherita Bracchi, et al
Lancet Infect Dis Published: July 01, 2022
DOI:https://doi.org/10.1016/S1473-3099(22)00411-X
Summary
Background
Historically, human monkeypox virus cases in the UK have been limited to imported infections f...
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Original Investigation May 17, 2022
Effect of Transcatheter Aortic Valve Implantation vs Surgical Aortic Valve Replacement on All-Cause Mortality in Patients With Aortic Stenosis: A Randomized Clinical Trial
The UK TAVI Trial Investigators
JAMA. 2022;327(19):1875-1887. doi:10.1001/jama.2022.5776
Key Points
Question Is transcatheter aortic valve implantation (TAVI) noninferior to surgical aortic valve replacement (surgery) in patien...
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ORIGINAL ARTICLEFREE PREVIEW
Valoctocogene Roxaparvovec Gene Therapy for Hemophilia A
Margareth C. Ozelo, Johnny Mahlangu, K. John Pasi, et al
N Engl J Med 2022; 386:1013-1025DOI: 10.1056/NEJMoa2113708
Abstract
BACKGROUND
Valoctocogene roxaparvovec (AAV5-hFVIII-SQ) is an adeno-associated virus 5 (AAV5)–based gene-therapy vector containing a coagulation factor VIII complementary DNA driven by a liver-selective promoter. The efficacy and safety of the...
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