Research Letter  April 22, 2024 Preoperative GLP-1 Receptor Agonist Use and Risk of Postoperative Respiratory Complications Anjali A. Dixit, Brian T. Bateman, Mary T. Hawn, et al JAMA. 2024;331(19):1672-1673. doi:10.1001/jama.2024.5003 In June 2023, the American Society of Anesthesiologists issued guidelines recommending preoperative withholding of glucagon-like peptide 1 receptor agonists (GLP-1 RAs),1 ...

Original Investigation  April 22, 2024 Associations Between Surrogate Markers and Clinical Outcomes for Nononcologic Chronic Disease Treatments Joshua D. Wallach, Samuel Yoon, Harry Doernberg, et al JAMA. 2024;331(19):1646-1654. doi:10.1001/jama.2024.4175 Key Points Question  What is the strength of association between surrogate markers used as primary end points in clinical trials to support Fo...

Original Investigation  April 25, 2024 Disparities in Mortality by Sexual Orientation in a Large, Prospective Cohort of Female Nurses Sarah McKetta, Tabor Hoatson, Landon D. Hughes, et al JAMA. 2024;331(19):1638-1645. doi:10.1001/jama.2024.4459 Key Points Question  Do bisexual and lesbian women have higher risks of premature mortality than heterosexual women? Findings  Bisexual and ...

Original Investigation  April 24, 2024 Neurodevelopmental Outcomes After Late Preterm Antenatal Corticosteroids: The ALPS Follow-Up Study Cynthia Gyamfi-Bannerman, Rebecca G. Clifton, Alan T. N. Tita, et al JAMA. 2024;331(19):1629-1637. doi:10.1001/jama.2024.4303 Key Points Question  Is administration of antenatal corticosteroids to individuals at risk of late preterm delivery, originally shown ...

Original Investigation  May 20, 2024 Time- vs Step-Based Physical Activity Metrics for Health Rikuta Hamaya, Eric J. Shiroma Jr, Christopher C. Moore, et al JAMA Intern Med. Published online May 20, 2024. doi:10.1001/jamainternmed.2024.0892 Key Points Question  Should women in their 60s or older rely on a clock or step counter for monitoring their physical activity (PA) levels for health? ...

Original Investigation  May 20, 2024 Survival Benefit Associated With Participation in Clinical Trials of Anticancer Drugs: A Systematic Review and Meta-analysis Renata Iskander, Hannah Moyer, Karine Vigneault, et al JAMA. Published online May 20, 2024. doi:10.1001/jama.2024.6281 Key Points Question  Is patient participation in cancer drug trials associated with longer survival? Findings ...

Navigating the Implementation of AI in Intensive Care Medicine In ICU Mon, 22 Apr 2024 Intensive care medicine is recognised as a promising field for implementing artificial intelligence (AI) due to the abundance of data generated in intensive care units (ICUs). However, despite the potential benefits, there is a significant gap between developed AI models and their actual clinical use. Challenges include technological issues in data quality, ethical a...

ARTICLES|ONLINE FIRST Decompressive craniectomy plus best medical treatment versus best medical treatment alone for spontaneous severe deep supratentorial intracerebral haemorrhage: a randomised controlled clinical trial Jürgen Beck, Christian Fung, Daniel Strbian, et al Lancet Published: May 15, 2024 DOI:https://doi.org/10.1016/S0140-6736(24)00702-5 Summary Background It is unknown whether decompressive craniectomy improves clinical outcome for peopl...

Original Investigation  May 19, 2024 Pamrevlumab for Idiopathic Pulmonary Fibrosis: The ZEPHYRUS-1 Randomized Clinical Trial Ganesh Raghu, Luca Richeldi, Evans R. Fernández Pérez, et al JAMA. Published online May 19, 2024. doi:10.1001/jama.2024.8693 Key Points Question  Does the connective tissue growth factor inhibitor pamrevlumab decrease the rate of decline in lung function for patients wit...

Original Investigation  Nephrology May 13, 2024 Blood Pressure, Readmission, and Mortality Among Patients Hospitalized With Acute Kidney Injury Benjamin R. Griffin, Mary Vaughan-Sarrazin, Qianyi Shi, et al JAMA Netw Open. 2024;7(5):e2410824. doi:10.1001/jamanetworkopen.2024.10824 Key Points Question  Following an episode of acute kidney injury (AKI), what is the ideal blood pressure range,...