Research Christmas 2024: Death is Just Around the Corner Alzheimer’s disease mortality among taxi and ambulance drivers: population based cross sectional study Vishal R Patel, Michael Liu, Christopher M Worsham, et al BMJ 2024; 387 doi: https://doi.org/10.1136/bmj-2024-082194 (Published 17 December 2024)Cite this as: BMJ 2024;387:e082194 Abstract Objective To analyze mortality attributed to Alzheimer’s disease among taxi drivers and ambulance driv...

Research Christmas 2024: Seasons of Love Effect of heated mittens on physical hand function in people with hand osteoarthritis: randomised controlled trial Cecilie Bartholdy, Anna Døssing, Zara R Stisen, et al BMJ 2024; 387 doi: https://doi.org/10.1136/bmj-2023-078222 (Published 17 December 2024)Cite this as: BMJ 2024;387:e078222 Abstract Objective To assess the effect of electrically heated mittens on physical hand function in people with osteoar...

Original Investigation  Health Policy October 16, 2024 Clinical Benefit, Price, and Regulatory Approval of Cancer Drugs Granted Breakthrough Therapy Designation in China, 2020-2024 Xingxian Luo, Xin Du, Xufeng Lv, et al JAMA Netw Open. 2024;7(10):e2439080. doi:10.1001/jamanetworkopen.2024.39080 Key Points Question  What are the differences in clinical benefit, clinical development time, novel...

Original Investigation  Pediatrics October 16, 2024 In Utero Exposure to Maternal COVID-19 and Offspring Neurodevelopment Through Age 24 Months Eleni G. Jaswa, Heather G. Huddleston, Karla J. Lindquist, et al JAMA Netw Open. 2024;7(10):e2439792. doi:10.1001/jamanetworkopen.2024.39792 Key Points Question  Is exposure to maternal SARS-CoV-2 infection in utero associated with increased risk for ...

ORIGINAL ARTICLE Safety of Kidney Transplantation from Donors with HIV Christine M. Durand, Allan Massie, Ph.D., Sander Florman, et al N Engl J Med 2024;391:1390-1401 Abstract BACKGROUND Kidney transplantation from donors with human immunodeficiency virus (HIV) to recipients with HIV is an emerging practice. It has been performed since 2016 under the U.S. congressional HIV Organ Policy Equity Act and is currently approved for research only. The Departmen...

Original Investigation  Caring for the Critically Ill Patient December 10, 2024 Electronic Sepsis Screening Among Patients Admitted to Hospital Wards: A Stepped-Wedge Cluster Randomized Trial Yaseen M. Arabi, Abdulmohsen Alsaawi, Mohammed Alzahrani, et al JAMA. Published online December 10, 2024. doi:10.1001/jama.2024.25982 Key Points Question  Does electronic sepsis screening based on quick ...

Original Investigation  Caring for the Critically Ill Patient December 10, 2024 High-Flow Nasal Oxygen vs Noninvasive Ventilation in Patients With Acute Respiratory Failure: The RENOVATE Randomized Clinical Trial RENOVATE Investigators and the BRICNet Authors JAMA. Published online December 10, 2024. doi:10.1001/jama.2024.26244 Key Points Question  Is high-flow nasal oxygen noninferior to noninvasive ventilation for rate of en...

Original Investigation  Caring for the Critically Ill Patient December 10, 2024 Early Restrictive vs Liberal Oxygen for Trauma Patients: The TRAUMOX2 Randomized Clinical Trial Tobias Arleth, Josefine Baekgaard, Volkert Siersma, et al JAMA. Published online December 10, 2024. doi:10.1001/jama.2024.25786 Key Points Question  Does an early, 8-hour restrictive oxygen strategy compared with a liberal oxygen strategy in severely inj...

ARTICLESVolume 12, Issue 10P787-798October 2024 Inhaled colistimethate sodium in patients with bronchiectasis and Pseudomonas aeruginosa infection: results of PROMIS-I and PROMIS-II, two randomised, double-blind, placebo-controlled phase 3 trials assessing safety and efficacy over 12 months Charles S Haworth, Michal Shteinberg, Kevin Winthrop, et al Lancet Respir Med 2024; 12: 787-798 Summary Background Chronic lung infection with Pseudomo...

ORIGINAL ARTICLE Liberal or Restrictive Transfusion Strategy in Aneurysmal Subarachnoid Hemorrhage Shane W. English, Anthony Delaney, Dean A. Fergusson, et al N Engl J Med Published December 9, 2024 DOI: 10.1056/NEJMoa2410962 Abstract BACKGROUND The effect of a liberal red-cell transfusion strategy as compared with a restrictive strategy in patients during the critical care period after an aneurysmal subarachnoid hemorrhage is unclear. METHODS W...