Monocyte HLA-DR expression in septic shock patients: insights from a 20-year real-world cohort of 1023 cases Monneret G, Lafon T, Gossez M, et al. Intensive Care Med(2025). https://doi.org/10.1007/s00134-025-08110-w Abstract Purpose Septic patients simultaneously experience hyperinflammation and immunosuppression, the latter driving ICU-acquired infections, prolonged stays in ICU, and increased mortality. As immunostimulant therapies enter clinical trials, ...

ONLINE FIRST (FREE ACCESS) STANDARD OF CARE IN THE INTENSIVE CARE UNIT What's New in Intensive Care Short piece: metabolic acidosisJung, B., Forni, L.G. & Jaber, S. Narrative Review Bedside thoracic echography in ICU: new insights for acute circulatory and respiratory failureMuller, L., Volpicelli, G., Mongodi, S. et al. Editorial Best practices in airway management in critically ill adultsDe Jong, A., Jaber, S. & Myatra, S.N. LATEST ARTICL...

Original Investigation  AI in Medicine An AI-Powered Lifestyle Intervention vs Human Coaching in the Diabetes Prevention Program: A Randomized Clinical Trial Nestoras Mathioudakis, Benjamin Lalani, Mohammed S. Abusamaan, et al JAMA Published Online: October 27, 2025 doi: 10.1001/jama.2025.19563 Key Points Question  How does referral to a lifestyle intervention exclusively driven by artificial...

Original Investigation  Critical Care Medicine Awake Prone Positioning in Patients With COVID-19 Respiratory Failure: A Randomized Clinical Trial Anatole Harrois, Romain Jouffroy, Soufia Ayed, et al JAMA Netw Open 2025;8;(12):e2548201. doi:10.1001/jamanetworkopen.2025.48201 Key Points Question  What are the effects of awake prone positioning on the incidence of intubation and/or death in nonintubated pati...

Original Investigation  Implications of Changing Institutions for Promotion in Academic Surgery Isabelle M. C. Tan, Haley Harris, Yuqing Qiu, et al JAMA Surg Published Online: December 10, 2025 doi: 10.1001/jamasurg.2025.5490 Key Points Question  Does changing institutions impact academic promotion pathways for academic surgeons? Findings  In this cohort study of 6321 surgical facul...

Research Letter  Occupational Health Disinfecting Wipes and Barrier Resistance of Protective Clothing F. Selcen Kilinc-Balci, Patrick L. Yorio, Zafer Kahveci, et al JAMA Netw Open 2025;8;(10):e2539307. doi:10.1001/jamanetworkopen.2025.39307 Introduction Protective clothing (PC), including gowns and coveralls, is crucial personal protective equipment (PPE) for health care and laboratory workers (HCLWs) to prevent transmission of contaminated fluids. ...

Original Investigation  Targeted Oxygen for Initial Resuscitation of Preterm Infants: The TORPIDO 30/60 Randomized Clinical Trial Ju Lee Oei, Adrienne Kirby, Javeed Travadi, et al JAMA Published Online: December 10, 2025 doi: 10.1001/jama.2025.23327 Key Points Question  Does initiating resuscitation of extremely preterm newborns with a higher level of fraction of inspired oxygen (Fio2; 0.6) redu...

Original Investigation  Cardiology Light Exposure at Night and Cardiovascular Disease Incidence Daniel P. Windred, Angus C. Burns, Martin K. Rutter, et al JAMA Netw Open 2025;8;(10):e2539031. doi:10.1001/jamanetworkopen.2025.39031 Key Points Question  Is personal light exposure at night associated with cardiovascular disease incidence? Findings  In this cohort study of 88 905 adults aged older than 40 years, exposure to bright...

Articles Prognostic accuracy of clinical markers of postpartum bleeding in predicting maternal mortality or severe morbidity: a WHO individual participant data meta-analysis Ioannis Gallos, Caitlin R Williams, Malcolm J Price, et al Lancet 2025; 406: 1969-1982 https://doi.org/10.1016/S0140-6736(25)01639-3 Summary Background Postpartum haemorrhage (excessive bleeding after birth) is a leading cause of maternal mortality and morbidity worldwide. However...

Original Investigation  Eltrombopag for Newly Diagnosed Pediatric Immune Thrombocytopenia Requiring Treatment: The PINES Randomized Clinical Trial Kristin A. Shimano, Amanda B. Grimes, Shipra Kaicker, et al JAMA Published Online: October 22, 2025 doi: 10.1001/jama.2025.18168 Key Points Question  What is the efficacy of eltrombopag compared with standard therapy in children with newly diagnosed i...