Original Investigation  Infectious Diseases March 14, 2025 Antimicrobial-Resistant Infections in Hospitalized Patients Hannah Wolford, Natalie L. McCarthy, James Baggs, et al JAMA Netw Open. 2025;8(3):e2462059. doi:10.1001/jamanetworkopen.2024.62059 Key Points Question  How has antimicrobial resistance changed from 2012 to 2022? Findings  In this cohort study of 7 158 139 culture...

Original Investigation  Infectious Diseases March 14, 2025 Probiotics and Fever Duration in Children With Upper Respiratory Tract Infections: A Randomized Clinical Trial Silvia Bettocchi, Anna Comotti, Marina Elli, et al JAMA Netw Open. 2025;8(3):e250669. doi:10.1001/jamanetworkopen.2025.0669 Key Points Question  Does a probiotic mixture containing Bifidobacterium breve M-16V, ...

Original Investigation Emergency Medicine March 14, 2025 Therapy Dogs for Anxiety in Children in the Emergency Department: A Randomized Clinical Trial Heather P. Kelker, Huma K. Siddiqui, Alan M. Beck, et al JAMA Netw Open. 2025;8(3):e250636. doi:10.1001/jamanetworkopen.2025.0636 Key Points Question  Can adjunctive use of therapy dogs in child-life therapy reduce both child-reported anxiety and pa...

Original Investigation  January 27, 2025 Negative Pressure Dressings to Prevent Surgical Site Infection After Emergency Laparotomy: The SUNRRISE Randomized Clinical Trial SUNRRISE Trial Study Group JAMA. 2025;333(10):853-863. doi:10.1001/jama.2024.24764 Key Points Question  Among patients undergoing emergency laparotomy, is there a difference in surgical site infection (SSI) rates when the wound is treated with incisional negative pre...

Original Investigation  March 10, 2025 Awake Prone Positioning in Adults With COVID-19: An Individual Participant Data Meta-Analysis Jian Luo, Ivan Pavlov, Elsa Tavernier, et al JAMA Intern Med. Published online March 10, 2025. doi:10.1001/jamainternmed.2025.0011 Key Points Question  Is awake prone positioning (APP) associated with better odds of survival without intubation compared with supine ...

ARTICLESVolume 405, Issue 10481P839-849March 08, 2025Download Full Issue Ivonescimab versus pembrolizumab for PD-L1-positive non-small cell lung cancer (HARMONi-2): a randomised, double-blind, phase 3 study in China Anwen Xiong, Lei Wang, Jianhua Chen, et al Lancet 2025; 405: 839-849 Summary Background Ivonescimab is a bispecific antibody against programmed cell death protein 1 and vascular endothelial growth factor, yielding promising clinical outc...

ARTICLESVolume 405, Issue 10481P813-838March 08, 2025Open AccessDownload Full Issue Global, regional, and national prevalence of adult overweight and obesity, 1990–2021, with forecasts to 2050: a forecasting study for the Global Burden of Disease Study 2021 GBD 2021 Adult BMI Collaborators Lancet 2025; 405: 813-838 Summary Background Overweight and obesity is a global epidemic. Forecasting future trajectories of the epidemic is crucial for providing...

ONLINE FIRST (FREE ACCESS) Artificial Intelligence in ICU Collection Editorial Setting the ventilator with AI support: challenges and perspectives Fritsch S. J. & Cecconi M. Natural language processing in critical care: opportunities, challenges, and future directionsMcNicholas B. A., Madden M. G. & Laffey J. G. Using AI to detect and treat delirium Young M., Kotfis K. & Bellomo R. OPEN ACCESS ~ Editorial How AI can help in erro...

ARTICLESVolume 405, Issue 10481P785-812March 08, 2025 Global, regional, and national prevalence of child and adolescent overweight and obesity, 1990–2021, with forecasts to 2050: a forecasting study for the Global Burden of Disease Study 2021 GBD 2021 Adolescent BMI Collaborators Lancet 2025; 405: 785-812 Summary Background Despite the well documented consequences of obesity during childhood and adolescence and future risks of excess body mass on non-com...

Original Investigation  Pediatrics March 6, 2025 Trends in Respiratory Pathogen Testing at US Children’s Hospitals Matthew J. Molloy, Matthew Hall, Jessica L. Markham, et al JAMA Netw Open. 2025;8(3):e250160. doi:10.1001/jamanetworkopen.2025.0160 Key Points Question  How have respiratory pathogen testing rates and costs changed over time for children and adolescents with acute respiratory inf...