ORIGINAL ARTICLE Discontinuation of Beta-Blocker Therapy after Myocardial Infarction Ki Hong Choi, Danbee Kang, Joon-Hyung Doh, et al N Engl J Med 2026;394:1302-1312 DOI: 10.1056/NEJMoa2601005 Abstract BACKGROUND The role of long-term beta-blocker therapy after a myocardial infarction in patients without left ventricular systolic dysfunction or heart failure is unclear in the era of contemporary coronary-artery reperfusion and secondary prevention int...

ONLINE FIRST (FREE ACCESS) PHYSIOLOGY IN CRITICAL ILLNESS What's New in Intensive Care Ventilator-induced lung injury: between tidal recruitment, overdistension, and the baby lung paradigmPlens, G.M., Costa, E.L.V. & Amato, M.B.P. How to interpret abnormal standard coagulation tests at the bedside in critically ill patients?Helms, J., Liu, L. & Russell, L. Understanding the Disease Immune responses and immunomodulation in sepsis: a call for ident...

Original Investigation  Caring for the Critically Ill Patient Integrated Telehealth Rehabilitation and Quality of Life in Mechanically Ventilated Adults: A Randomized Clinical Trial Regis Goulart Rosa, Rafael Barberena Moraes, Geraldine Trott, et al JAMA Published Online: June 10, 2026 doi: 10.1001/jama.2026.10617 Key Points Question  Among adults with acute hypoxemic respiratory failure requiring invasive mechanical ventilation, does a...

ORIGINAL ARTICLE Hospital Policy of Tranexamic Acid to Reduce Transfusion in Major Noncardiac Surgery Brett L. Houston, Daniel I. McIsaac, Rodney H. Breau, et al N Engl J Med Published June 10, 2026 DOI: 10.1056/NEJMoa2515820 Abstract BACKGROUND Whether a hospital policy of tranexamic acid administration for patients undergoing major noncardiac surgery safely reduces the need for red-cell transfusion is uncertain. METHODS We conducted a multicen...

ORIGINAL ARTICLE Conservative Oxygen for Unresponsive Patients after Cardiac Arrest The LOGICAL Investigators and the Australian and New Zealand Intensive Care Society Clinical Trials Group N Engl J Med Published June 10, 2026 DOI: 10.1056/NEJMoa2513814 Abstract BACKGROUND In patients who are unresponsive after resuscitation from cardiac arrest, limiting oxygen exposure to that necessary to achieve acceptable oxygenation may increase the likelihood of...

Research Accuracy of glomerular filtration rate estimation based on creatinine and cystatin C for monitoring moderate chronic kidney disease in adults: prospective, longitudinal cohort study Katie Scandrett, Alice J Sitch, Jonathan Barratt, et al BMJ 2026; 392 doi: https://doi.org/10.1136/bmj-2025-085005 (Published 19 March 2026)Cite this as: BMJ 2026;392:e085005 Abstract Objectives To provide evidence on the longitudinal accuracy of glomerular filtrat...

Original Investigation  Transesophageal Echocardiography During CPR in Patients With Out-of-Hospital Cardiac Arrest: The EXECT-CPR Randomized Clinical Trial Sheng-En Chu, Chiao-Yin Cheng, Chih-Jung Chang, et al JAMA Intern Med Published Online: March 23, 2026 doi: 10.1001/jamainternmed.2026.0102 Key Points Question  Does transesophageal echocardiography (TEE)–guided cardiopulmonary resuscitation...

ARTICLE March 22, 2026 Procalcitonin testing combined with NEWS2 evaluation compared with usual care based on NEWS2 for identification of sepsis and antibiotic initiation in the emergency department in England and Wales (PRONTO): a multicentre, randomised, controlled, open-label, phase 3 trial Stacy Todd, Joanne Euden, Jennifer Condie, et al Lancet Respir Med Published March 22, 2026 DOI: 10.1016/S2213-2600(25)00433-3 Summary Background Sepsis is a co...

Original Investigation  Caring for the Critically Ill Patient National Estimates of Pediatric Sepsis in US Hospitals Using Clinical Data Chanu Rhee, Fran Balamuth, Kevin Dysart, et al JAMA Published Online: March 22, 2026 doi: 10.1001/jama.2026.3100 Key Points Question  What is the burden of nonneonatal pediatric sepsis in US hospitals using an electronic health record–based surveillance defi...

ARTICLES March 21, 2026Open Access Endotracheal surfactant for infants with life-threatening bronchiolitis (BESS): a randomised, blinded, sham-controlled, phase 2 trial Malcolm G Semple, Chloe Donohue, Laura Price, et al Lancet Respir Med Published March 21, 2026 DOI: 10.1016/S2213-2600(26)00008-1 Summary Background Bronchiolitis is a common viral respiratory disease of infants, with severity ranging from mild symptoms, such as coryza and feeding diff...