Fluid responsiveness in acute respiratory distress syndrome patients: a post hoc analysis of the HEMOPRED study Joseph, A., Evrard, B., Petit, M. et al. Intensive Care Med(2024). https://doi.org/10.1007/s00134-024-07639-6 Abstract Purpose Optimal fluid management in patients with acute respiratory distress syndrome (ARDS) is challenging due to risks associated with both circulatory failure and fluid overload. The performance of dynamic indices to predict fl...

Epidemiology of acute hypoxaemic respiratory failure in Australian and New Zealand intensive care units during 2005–2022. A binational, registry-based study Ling, R.R., Ponnapa Reddy, M., Subramaniam, A. et al. Intensive Care Med (2024). https://doi.org/10.1007/s00134-024-07609-y Abstract Purpose Acute hypoxaemic respiratory failure (AHRF) is a common reason for intensive care unit (ICU) admission. However, patient characteristics, outcomes, and trends over...

Landiolol for heart rate control in patients with septic shock and persistent tachycardia. A multicenter randomized clinical trial (Landi-SEP) Rehberg, S., Frank, S., Černý, V. et al. Intensive Care Med 50, 1622–1634 (2024) https://doi.org/10.1007/s00134-024-07587-1 Abstract Purpose Excessive tachycardia in resuscitated septic shock patients can impair hemodynamics and worsen patient outcome. We investigated whether heart rate (HR) control can be achieve...

ONLINE FIRST (FREE ACCESS) LATEST ARTICLES "ICU TOOLBOX" TOPICAL COLLECTION EditorialClinical governance in intensive care medicineCarenzo L., Constantini E. and Cecconi M. When should I start broad-spectrum antibiotics?Timsit J-F., Depuydt P. and Kanj S. S. Diagnostic tests for infections in critically ill immunocompromised patientsDumas G., Joseph A. and Zafrani L. Understanding the DiseaseUnderstanding buffering of metabolic acidosis in critical illne...

Low-dose clonidine infusion to improve sleep in postoperative patients in the high-dependency unit. A randomised placebo-controlled single-centre trial Liu, D., Hallt, E., Platz, A. et al. Intensive Care Med (2024). https://doi.org/10.1007/s00134-024-07619-w Abstract Purpose Dexmedetomidine increases sleep and reduces delirium in postoperative patients, but it is expensive and requires a monitored environment. Clonidine, another 2-agonist, is cheaper a...

Pressure control plus spontaneous ventilation versus volume assist-control ventilation in acute respiratory distress syndrome. A randomised clinical trial Richard, JC.M., Beloncle, F.M., Béduneau, G. et al. Intensive Care Med 50, 1647–1656 (2024). https://doi.org/10.1007/s00134-024-07612-3 Abstract Purpose The aim of this study was to compare the effect of a pressure-controlled strategy allowing non-synchronised unassisted spontaneous ventilation (PC-SV)...

ORIGINAL ARTICLE Antibiotic Treatment for 7 versus 14 Days in Patients with Bloodstream Infections The BALANCE Investigators, for the Canadian Critical Care Trials Group, the Association of Medical Microbiology and Infectious Disease Canada Clinical Research Network, the Australian and New Zealand Intensive Care Society Clinical Trials Group, and the Australasian Society for Infectious Diseases Clinical Research Network N Engl J Med Published November 20, 2024 ...

Original Investigation  October 2, 2024 Tranexamic Acid During Radical Cystectomy: A Randomized Clinical Trial Rodney H. Breau, Luke T. Lavallée, Ilias Cagiannos, et al JAMA Surg. Published online October 2, 2024. doi:10.1001/jamasurg.2024.4183 Key Points Question  Does intraoperative prophylactic tranexamic acid reduce blood transfusion in patients undergoing open radical cystectomy? Finding...

Research Letter  Pacific Coast Surgical Association September 25, 2024 Antibiotic Prophylaxis for Surgical Site Infection After Traumatic Hollow Viscus Injury Janelle Cyprich, Amy H. Kaji, Alexandra Moulton, et al JAMA Surg. Published online September 25, 2024. doi:10.1001/jamasurg.2024.3827 Surgical site infection (SSI) is a major cause of morbidity after trauma laparotomy. Hollow viscus injury (HVI) inc...

Original Investigation  Pharmacy and Clinical Pharmacology September 26, 2024 Tongxinluo and Functional Outcomes Among Patients With Acute Ischemic Stroke: A Randomized Clinical Trial Yi Dong, Kaifu Jiang, Zhenguang Li, et al JAMA Netw Open. 2024;7(9):e2433463. doi:10.1001/jamanetworkopen.2024.33463 Key Points Question  Can the antioxidant drug Tongxinluo, which consists of 12 traditional Chi...