Prolonged vs shorter awake prone positioning for COVID-19 patients with acute respiratory failure: a multicenter, randomised controlled trial Liu, L., Sun, Q., Zhao, H. et al. Intensive Care Med 50, 1298–1309 (2024) https://doi.org/10.1007/s00134-024-07545-x Abstract Purpose Awake prone positioning has been reported to reduce endotracheal intubation in patients with coronavirus disease 2019 (COVID-19)-related acute hypoxemic respiratory failure (AHRF). H...

ONLINE FIRST (FREE ACCESS) "ICU TOOLBOX" TOPICAL COLECTION Editorial Citrate anticoagulation for continuous renal replacement therapy Honoré P. M., Rimmelé T. and Joannes-Boyau O. How to end quiet suffering in the intensive care unit? Identifying and treating hypoactive deliriumKotfis K., Mesa P. and E. Wesley Ely E. W. "MY GREEN ICU" COLECTION CorrespondenceGreen ICU is good, but not perfect Chen R-X INTENSIVE CARE IN RESOURCE LIMITED SETTINGS ...

Original Investigation  Statistics and Research Methods September 6, 2024 Agreement Between Mega-Trials and Smaller Trials: A Systematic Review and Meta-Research Analysis Lum Kastrati, Hamidreza Raeisi-Dehkordi, Erand Llanaj, et al JAMA Netw Open. 2024;7(9):e2432296. doi:10.1001/jamanetworkopen.2024.32296 Key Points Question  Are the results of mega-trials with 10 000 participants or more sim...

ARTICLESVolume 12, Issue 9P714-727September 2024 Estimated number of lives directly saved by COVID-19 vaccination programmes in the WHO European Region from December, 2020, to March, 2023: a retrospective surveillance study Margaux M I Meslé, Jeremy Brown, Piers Mook, et al Lancet Respir Med 2024; 12: 714-727 Summary Background By March, 2023, 54 countries, areas, and territories (hereafter CAT) in the WHO European Regi...

Disease Outbreak News Antimicrobial Resistance, Hypervirulent Klebsiella pneumoniae - Global situation 31 July 2024 WHO risk assessment Globally, there is no systematic surveillance that allows for the routine identification and information collection of hvKp strains. Identification of hvKp is challenging given that it is determined by available laboratory capacity to perform genomic sequencing tests or analysis of specific markers that may indicate hypervirul...

ARTICLESOnline first100894August 22, 2024Open Access Early warning COVID-19 outbreak in long-term care facilities using wastewater surveillance: correlation, prediction, and interaction with clinical and serological statuses Xiaoli Pang, Bonita E Lee, Tiejun Gao, et al Lancet Microbe 2024 https://doi.org/10.1016/S2666-5247(24)00126-5 Summary Background The unprecedented COVID-19 pandemic has highlighted the strategic value of wastewater-based surveillanc...

ARTICLESVolume 5, Issue 9100864 September 2024 Open Access Association between butyrate-producing gut bacteria and the risk of infectious disease hospitalisation: results from two observational, population-based microbiome studies Robert F J Kullberg, Irina Wikki, Bastiaan W Haak, et al Lancet Microbe 2024; 5: 10086 Summary Background Microbiota alterations are common in patients hospitalised for severe infections, and preclinical models have shown that ...

Disease Outbreak NewsAntimicrobial Resistance, Hypervirulent Klebsiella pneumoniae - Global situation31 July 2024 Situation at a glance In early 2024, the Global Antimicrobial Resistance and Surveillance System on Emerging Antimicrobial Resistance Reporting (GLASS-EAR) issued a request for information to assess the current global situation given the increased identification of isolates of hypervirulent Klebsiella pneumoniae (hvKp) sequence type (ST) 23 carrying re...

Original Investigation  August 30, 2024 Prehospital Pulse-Dose Glucocorticoid in ST-Segment Elevation Myocardial Infarction: The PULSE-MI Randomized Clinical Trial Jasmine Melissa Madsen, Thomas Engstrøm, Laust Emil Roelsgaard Obling, et al JAMA Cardiol. Published online August 30, 2024. doi:10.1001/jamacardio.2024.2298 Key Points Question  In patients with ST-segment elevation myocardial infarc...

Original Investigation  August 31, 2024 Potassium Supplementation and Prevention of Atrial Fibrillation After Cardiac Surgery: The TIGHT K Randomized Clinical Trial Benjamin O’Brien,Niall G. Campbell, Elizabeth Allen, et al JAMA. Published online August 31, 2024. doi:10.1001/jama.2024.17888 Key Points Question  When trying to prevent atrial fibrillation after cardiac surgery (AFACS), is supplementing...