ONLINE FIRST (FREE ACCESS) LATEST ARTICLES "ICU TOOLBOX" TOPICAL COLLECTION EditorialClinical governance in intensive care medicineCarenzo L., Constantini E. and Cecconi M. When should I start broad-spectrum antibiotics?Timsit J-F., Depuydt P. and Kanj S. S. Diagnostic tests for infections in critically ill immunocompromised patientsDumas G., Joseph A. and Zafrani L. Understanding the DiseaseUnderstanding buffering of metabolic acidosis in critical illne...

Low-dose clonidine infusion to improve sleep in postoperative patients in the high-dependency unit. A randomised placebo-controlled single-centre trial Liu, D., Hallt, E., Platz, A. et al. Intensive Care Med (2024). https://doi.org/10.1007/s00134-024-07619-w Abstract Purpose Dexmedetomidine increases sleep and reduces delirium in postoperative patients, but it is expensive and requires a monitored environment. Clonidine, another 2-agonist, is cheaper a...

Pressure control plus spontaneous ventilation versus volume assist-control ventilation in acute respiratory distress syndrome. A randomised clinical trial Richard, JC.M., Beloncle, F.M., Béduneau, G. et al. Intensive Care Med 50, 1647–1656 (2024). https://doi.org/10.1007/s00134-024-07612-3 Abstract Purpose The aim of this study was to compare the effect of a pressure-controlled strategy allowing non-synchronised unassisted spontaneous ventilation (PC-SV)...

ORIGINAL ARTICLE Antibiotic Treatment for 7 versus 14 Days in Patients with Bloodstream Infections The BALANCE Investigators, for the Canadian Critical Care Trials Group, the Association of Medical Microbiology and Infectious Disease Canada Clinical Research Network, the Australian and New Zealand Intensive Care Society Clinical Trials Group, and the Australasian Society for Infectious Diseases Clinical Research Network N Engl J Med Published November 20, 2024 ...

Original Investigation  October 2, 2024 Tranexamic Acid During Radical Cystectomy: A Randomized Clinical Trial Rodney H. Breau, Luke T. Lavallée, Ilias Cagiannos, et al JAMA Surg. Published online October 2, 2024. doi:10.1001/jamasurg.2024.4183 Key Points Question  Does intraoperative prophylactic tranexamic acid reduce blood transfusion in patients undergoing open radical cystectomy? Finding...

Research Letter  Pacific Coast Surgical Association September 25, 2024 Antibiotic Prophylaxis for Surgical Site Infection After Traumatic Hollow Viscus Injury Janelle Cyprich, Amy H. Kaji, Alexandra Moulton, et al JAMA Surg. Published online September 25, 2024. doi:10.1001/jamasurg.2024.3827 Surgical site infection (SSI) is a major cause of morbidity after trauma laparotomy. Hollow viscus injury (HVI) inc...

Original Investigation  Pharmacy and Clinical Pharmacology September 26, 2024 Tongxinluo and Functional Outcomes Among Patients With Acute Ischemic Stroke: A Randomized Clinical Trial Yi Dong, Kaifu Jiang, Zhenguang Li, et al JAMA Netw Open. 2024;7(9):e2433463. doi:10.1001/jamanetworkopen.2024.33463 Key Points Question  Can the antioxidant drug Tongxinluo, which consists of 12 traditional Chi...

Original Investigation  Health Policy September 27, 2024 Treatment Effects in Randomized and Nonrandomized Studies of Pharmacological Interventions: A Meta-Analysis Maximilian Salcher-Konrad, Mary Nguyen, Jelena Savović, et al JAMA Netw Open. 2024;7(9):e2436230. doi:10.1001/jamanetworkopen.2024.36230 Key Points Question  How do treatment effects for drugs compare when obtained from nonrandomi...

Original Investigation  Equity, Diversity, and Inclusion September 24, 2024 Race and Sex Disparities Among Emergency Medicine Chief Residents Jennifer W. Tsai, Mytien Nguyen, Sarah N. Dudgeon, et al JAMA Netw Open. 2024;7(9):e2432679. doi:10.1001/jamanetworkopen.2024.32679 Key Points Question  Do racial disparities for selecting emergency medicine chief residency exist? Findings  ...

Original Investigation  Pediatrics September 25, 2024 Lung Recruitment Before Surfactant Administration in Extremely Preterm Neonates: 2-Year Follow-Up of a Randomized Clinical Trial Francesca Gallini, Domenico Umberto De Rose, Roberta Iuliano, et al JAMA Netw Open. 2024;7(9):e2435347. doi:10.1001/jamanetworkopen.2024.35347 Key Points Question  Did infants who underwent the intubate-recruit-s...