Original Investigation  Caring for the Critically Ill Patient December 10, 2024 Early Restrictive vs Liberal Oxygen for Trauma Patients: The TRAUMOX2 Randomized Clinical Trial Tobias Arleth, Josefine Baekgaard, Volkert Siersma, et al JAMA. Published online December 10, 2024. doi:10.1001/jama.2024.25786 Key Points Question  Does an early, 8-hour restrictive oxygen strategy compared with a liberal oxygen strategy in severely inj...

ARTICLESVolume 12, Issue 10P787-798October 2024 Inhaled colistimethate sodium in patients with bronchiectasis and Pseudomonas aeruginosa infection: results of PROMIS-I and PROMIS-II, two randomised, double-blind, placebo-controlled phase 3 trials assessing safety and efficacy over 12 months Charles S Haworth, Michal Shteinberg, Kevin Winthrop, et al Lancet Respir Med 2024; 12: 787-798 Summary Background Chronic lung infection with Pseudomo...

ORIGINAL ARTICLE Liberal or Restrictive Transfusion Strategy in Aneurysmal Subarachnoid Hemorrhage Shane W. English, Anthony Delaney, Dean A. Fergusson, et al N Engl J Med Published December 9, 2024 DOI: 10.1056/NEJMoa2410962 Abstract BACKGROUND The effect of a liberal red-cell transfusion strategy as compared with a restrictive strategy in patients during the critical care period after an aneurysmal subarachnoid hemorrhage is unclear. METHODS W...

Original Investigation  Caring for the Critically Ill Patient December 9, 2024 Biomarker-Guided Antibiotic Duration for Hospitalized Patients With Suspected Sepsis: The ADAPT-Sepsis Randomized Clinical Trial Paul Dark, Anower Hossain, Daniel F. McAuley, et al JAMA. Published online December 9, 2024. doi:10.1001/jama.2024.26458 Key Points Question  Do critically ill adult patients hospitalized for suspected sepsis and treated w...

Aztreonam–avibactam versus meropenem for the treatment of serious infections caused by Gram-negative bacteria (REVISIT): a descriptive, multinational, open-label, phase 3, randomised trial Yehuda Carmeli, José Miguel Cisneros, Mical Paul, et al. Lancet Infect Dis 2024 Available online 7 October 2024 https://doi.org/10.1016/S1473-3099(24)00499-7 Summary Background There is a need for additional therapeutic options for serious infections caused by Gram-neg...

Adjunctive linezolid versus clindamycin for toxin inhibition in β-lactam-treated patients with invasive group A streptococcal infections in 195 US hospitals from 2016 to 2021: a retrospective cohort study with target trial emulation Ahmed Babiker, Sarah Warner, Xiaobai Li, et al. Lancet Infect Dis 2024 Available online 10 October 2024 https://doi.org/10.1016/S1473-3099(24)00507-3 Summary Background Adjunctive clindamycin use...

Mechanisms and causes of death after abdominal surgery in low-income and middle-income countries: a secondary analysis of the FALCON trial NIHR Global Health Research Unit on Global Surgery Lancet Global Health 2024 online first September 05, 2024 https://doi.org/10.1016/S2214-109X(24)00318-8 Summary Background Death after surgery is devasting for patients, families, and communities, but remains common in low-income and middle-income countries (LMICs). W...

Microbiology testing capacity and antimicrobial drug resistance in surgical-site infections: a post-hoc, prospective, secondary analysis of the FALCON randomised trial in seven low-income and middle-income countries NIHR Global Health Research Unit on Global Surgery Lancet Global Health 2024 epub ahead of print https://doi.org/10.1016/S2214-109X(24)00330-9 Summary Background Surgical-site infection (SSI) is one of the most common health-care-associated i...

Global estimation of dietary micronutrient inadequacies: a modelling analysis Simone Passarelli, Christopher M Free, Alon Shepon, et al Lancet Global Health 2024; 12: e1590-e1599 Summary Background Inadequate micronutrient intakes and related deficiencies are a major challenge to global public health. Analyses over the past 10 years have assessed global micronutrient deficiencies and inadequate nutrient supplies, but there have been no global estimates of i...

ONLINE FIRST (FREE ACCESS) LATEST ARTICLES Conference Reports and Expert Panel European Society of Intensive Care Medicine guidelines on end of life and palliative care in the intensive care unit Kesecioglu J. et al Original The impact of the massive open online course C19_SPACE during the COVID-19 pandemic on clinical knowledge enhancement: a study among medical doctors and nurses Cecconi M. et al OPEN ACCESS ~ Original Coaching doctors to...