ORIGINAL ARTICLE Vutrisiran in Patients with Transthyretin Amyloidosis with Cardiomyopathy Marianna Fontana, John L. Berk, Julian D. Gillmore, et al N Engl J Med 2025;392:33-44 DOI: 10.1056/NEJMoa2409134 Abstract BACKGROUND Transthyretin amyloidosis with cardiomyopathy (ATTR-CM) is a progressive, fatal disease. Vutrisiran, a subcutaneously administered RNA interference therapeutic agent, inhibits the production of hepatic transthyretin. 转甲状腺素...

Research Letter  November 11, 2024 Online Retailer Nonadherence to Age Verification, Shipping, and Flavor Restrictions on E-Cigarettes Raquel M. Harati, Shannon E. Ellis, Nora Satybaldiyeva, et al JAMA. 2024;332(24):2113-2114. doi:10.1001/jama.2024.21597 To curtail youth access to vaping products, the 2020 Preventing Online Sales of E-Cigarettes to Children Act implemented a ban on the use of the United States Postal ...

Original Investigation  December 30, 2024 Pain Coping Skills Training for Patients Receiving Hemodialysis: The HOPE Consortium Randomized Clinical Trial Laura M. Dember, Jesse Y. Hsu, Rajnish Mehrotra, et al JAMA Intern Med. Published online December 30, 2024. doi:10.1001/jamainternmed.2024.7140 Key Points Question  Does pain coping skills training (PCST), a cognitive behavioral intervention, re...

Original Investigation  December 23, 2024 Variation in Emergency Department Physician Admitting Practices and Subsequent Mortality Stephen Coussens, Dan P. Ly JAMA Intern Med. Published online December 23, 2024. doi:10.1001/jamainternmed.2024.6925 Key Points Question  By how much does the propensity to admit patients vary across physicians within a given emergency department (ED), and do higher admission prope...

Original Investigation  Infectious Diseases December 23, 2024 Clinical Outcomes of Early Phenotype-Desirable Antimicrobial Therapy for Enterobacterales Bacteremia Rena C. Moon, Shawn H. MacVane, Joy David, et al JAMA Netw Open. 2024;7(12):e2451633. doi:10.1001/jamanetworkopen.2024.51633 Key Points Question  Is the timing of phenotype-desirable antimicrobial therapy (PDAT; ie, a β-la...

Research Letter  November 7, 2024 Industry Payments to Physicians by Competing Manufacturers Within Novel Therapeutic Classes Q. Wilton Sun, Joseph S. Ross JAMA. 2024;332(24):2111-2113. doi:10.1001/jama.2024.20842 Pharmaceutical manufacturers make extensive payments to physicians for marketing purposes, including for speaking, travel, attending promotional events, and consulting arrangements,1,2 with well-documented influence o...

Original Investigation  November 6, 2024 Postmarketing Surveillance of Inferior Vena Cava Filters Among US Medicare Beneficiaries: The SAFE-IVC Study Enrico G. Ferro, Julie B. Mackel, Renee D. Kramer, et al JAMA. 2024;332(24):2091-2100. doi:10.1001/jama.2024.19553 Key Points Question  What are the contemporary practice patterns and clinical outcomes of inferior vena cava filter (IVCF) insertion and retrie...

Original Investigation  Public Health October 21, 2024 Prevalence and Risk Factors of Gang Membership in a Brazilian Birth Cohort Andreas Bauer, Rafaela Costa Martins, Gemma Hammerton, et al JAMA Netw Open. 2024;7(10):e2440393. doi:10.1001/jamanetworkopen.2024.40393 Key Points Question  Are adverse childhood experiences (ACEs) associated with increased risk of gang membership in a low- and mi...

Research Letter  September 30, 2024 Trends in Female Physicians Entering High-Compensation Specialties, 2008 to 2022 Karina Pereira-Lima, Srijan Sen, Sujatha Changolkar, et al JAMA. 2024;332(16):1390-1392. doi:10.1001/jama.2024.17516 National reports show that women constituted 55% of incoming US medical students in 2023 and 38% of the physician workforce in 2022.1,2 However, women remain underrepresented in high...

Original Investigation  Infectious Diseases December 20, 2024 β-Lactam Inoculum Effect in Methicillin-Susceptible Staphylococcus aureus Infective Endocarditis Baptiste Jean, Maelys Crolle, Candice Pollani, et al JAMA Netw Open. 2024;7(12):e2451353. doi:10.1001/jamanetworkopen.2024.51353 Key Points Question  Is the clinical outcome of methicillin-susceptible Staphylococcus aureu...