CRITICAL CARE: ORIGINAL RESEARCH Ceftriaxone to Prevent Early-Onset Pneumonia in Comatose Patients Following Out-of-Hospital Cardiac Arrest: A Pilot Randomized Controlled Trial and Resistome Assessment (PROTECT) David J. Gagnon, Kristin M. Burkholder, Bram J. Geller, et al Chest 2025; 169: 115-127 DOI: 10.1016/j.chest.2025.08.007  Abstract Background Antibiotic prophylaxis following out-of-hospital cardiac arrest (OHCA) reduces early-onset pneumonia. ...

Original Investigation  Aging and Health Changes in US Skilled Nursing Facility Capacity Following the COVID-19 Pandemic Brian E. McGarry, Andrew D. Wilcock, Ashvin D. Gandhi, et al JAMA Intern Med Published Online: January 12, 2026 doi: 10.1001/jamainternmed.2025.7197 Key Points Question  Has US skilled nursing facility (SNF) capacity changed following the COVID-19 pandemic? Findings ...

Research Letter  National Trends in Pediatric Inpatient Capacity Kenneth A. Michelson, Anna M. Cushing, Emily M. Bucholz JAMA Pediatr 2025;179;(2):208-209. doi:10.1001/jamapediatrics.2024.5110 Most pediatric hospitalizations occur in general hospitals, which increasingly transfer rather than hospitalize children, resulting in care concentration at large pediatric centers.1 This shift in pediatric care delivery is partly ...

CLINICAL INVESTIGATION Targeted Tissue Perfusion Versus Macrocirculatory-Guided Standard Care in Patients With Septic Shock: A Randomized Clinical Trial—The TARTARE-2S Trial Pettilä, Ville; Pfortmüller, Carmen A; Perner, Anders; et al Critical Care Medicine 54(1):p 24-34, January 2026. | DOI: 10.1097/CCM.0000000000006899 Abstract Objectives:  To determine whether treatment targeting improving tissue perfusion while allowing lower than recommende...

Original Investigation  Effectiveness and Cost-Effectiveness of Automated External Defibrillators in Private Homes: A Report From the Cardiac Arrest Registry to Enhance Survival Lars W. Andersen, Mathias J. Holmberg, Eline Krijkamp, et al JAMA Intern Med 2026;186;(1):37-43. doi:10.1001/jamainternmed.2025.6123 Key Points Question  Are automated external defibrillations (AEDs) in private homes effective and co...

ONLINE FIRST (FREE ACCESS) MY GREEN ICU Correspondence Integrating sustainability into critical care undergraduate education: preparing future physicians for a climate-conscious practice. Author's replyBoissier, F., Poissy, J., Lecronier, M. et al. STANDARD OF CARE IN THE INTENSIVE CARE UNIT Editorial Stepwise fluid management in critical illnessMekontso Dessap, A., Cecconi, M. LATEST ARTICLES EditorialChecking methodology and statistics when readi...

Original Investigation  Emergency Medicine Ketamine, Etomidate, and Mortality in Emergency Department Intubations Ian Ward A. Maia, Sérgio R. R. Decker, Lucas Oliveira J. e Silva, et al JAMA Netw Open 2025;8;(12):e2548060. doi:10.1001/jamanetworkopen.2025.48060 Key Points Question  Among critically ill adults undergoing rapid sequence intubation, is etomidate use associated with higher in-hospital mortali...

Original Investigation  Critical Care Medicine Cost-Effectiveness of Pantoprazole to Prevent Upper Gastrointestinal Bleeding in Mechanically Ventilated Patients Feng Xie, Yifan Yao, Yue Ma, et al JAMA Netw Open 2025;8;(12):e2552771. doi:10.1001/jamanetworkopen.2025.52771 Key Points Question  Is daily intravenous pantoprazole cost-effective in preventing upper gastrointestinal bleeding in mechanically vent...

ONLINE FIRST (FREE ACCESS) STANDARD OF CARE IN THE INTENSIVE CARE UNIT What's New in Intensive Care Ten ethical challenges in donation after circulatory death (DCD): a practical guide for intensivistsVergano, M., Metaxa, V. & Citerio, G. LATEST ARTICLES OriginalTrends in renal replacement therapy use in intensive care unit: insights from a French multicenter cohortSchmidt, J., Grimaldi, L., Martel, P. et al. OPEN ACCESS ~ Original Temporal ro...

Original Investigation  Less Is More Antibiotic De-Escalation in Adults Hospitalized for Community-Onset Sepsis Ashwin B. Gupta, Megan Heath, Emily Walzl, et al JAMA Intern Med Published Online: December 22, 2025 doi: 10.1001/jamainternmed.2025.6919 Key Points Question  Is broad-spectrum antibiotic de-escalation on encounter day 4 safe among patients hospitalized with community-onset sepsis w...