Original Investigation  Cardiology Sivelestat and Incidence of Acute Respiratory Distress Syndrome After Cardiovascular Surgery: A Randomized Clinical Trial Tuo Pan, Can Xu, Ya-Peng Wang, et al JAMA Netw Open 2026;9;(3):e260390. doi:10.1001/jamanetworkopen.2026.0390 Key Points Question  Does postoperative administration of the neutrophil elastase inhibitor sivelestat reduce the incidence of acute respiratory dis...

ONLINE FIRST (FREE ACCESS) PHYSIOLOGY IN CRITICAL ILLNESS Understanding the Disease Understanding lung physiology through ventilator screenCarteaux, G., Spinelli, E. & Jaber, S. LATEST ARTICLES OriginalPlasminogen supplementation reverses fibrinolytic insufficiency in sepsis-induced disseminated intravascular coagulation: a pilot studyTschirhart, M., Curtiaud, A., Abou Rjeily, R. et al. OPEN ACCESS ~ Original Association between ABCDE bundle ...

Original Investigation  Emergency Medicine Incidence of Out-of-Hospital Cardiac Arrest on a Postholiday Weekday Min-Su Cha, Myoung-Je Song, Jong-Sun Kim JAMA Netw Open 2026;9;(3):e260832. doi:10.1001/jamanetworkopen.2026.0832 Key Points Question  Is a postholiday weekday associated with a higher out-of-hospital cardiac arrest incidence vs baseline weekdays in South Korea? Findings  In this cohort ...

Articles Blood biomarkers for the prediction of outcome after cardiac arrest: an international prospective observational study within the Targeted Hypothermia versus Normothermia after Out-of-Hospital Cardiac Arrest (TTM2) trial Marion Moseby-Knappe, Helena Levin, Susann Ullén, et al Lancet Respir Med Available online 11 December 2025 https://doi.org/10.1016/S2213-2600(25)00363-7 Summary Background Prognostication of recovery in patients who are uncon...

Articles Hospital and long-term outcomes for subglottic suction and polyurethane cuff versus standard endotracheal tubes in emergency intubation (PreVent 2): a randomised controlled phase 2 trial Miriam M Treggiari, Emily S Sharp, Tetsu Ohnuma, et al Lancet Respir Med 2026; 14: 141-150 https://doi.org/10.1016/S2213-2600(25)00294-2 Summary Background Endotracheal tubes with subglottic ports and a polyurethane cuff are recommended for reducing microaspi...

Articles Accounting for non-adherence to assigned antibiotic treatment duration for bloodstream infection (BALANCE): a post-hoc analysis of a randomised clinical trial Sean W X Ong, Ruxandra Pinto, Robert K Mahar, et al Lancet Infect Dis 2026; 26: 250-259 https://doi.org/10.1016/S1473-3099(25)00592-4 Summary Background The BALANCE trial (NCT03005145) showed non-inferiority of 7-day versus 14-day antibiotic duration for treatment of patients with non-S...

Research Machine learning based screening of potential paper mill publications in cancer research: methodological and cross sectional study Baptiste Scancar, Jennifer A Byrne, David Causeur, et al BMJ 2026; 392 doi: https://doi.org/10.1136/bmj-2025-087581 (Published 30 January 2026)Cite this as: BMJ 2026;392:e087581 Abstract Objectives To train and validate a machine learning model to distinguish paper mill publ...

Original Investigation  Health Policy Hospital Nurse Understaffing and Patient Mortality, Readmission, and Length of Stay Noriko Morioka, Mutsuko Moriwaki, Atsushi Miyawaki, et al JAMA Netw Open 2026;9;(2):e2558235. doi:10.1001/jamanetworkopen.2025.58235 Key Points Question  Is nurse understaffing during the day shift or evening and night shift, relative to typical ward staffing levels, associated with pa...

Original Investigation  Worldwide Radiation Dose in Coronary Artery Disease Diagnostic Imaging Andrew J. Einstein, Michelle C. Williams, Jonathan R. Weir-McCall, et al JAMA Published Online: February 25, 2026 doi: 10.1001/jama.2026.0703 Key Points Question  How does radiation dose from cardiac diagnostic testing vary worldwide? Findings  In this cross-sectional study in 101 countrie...

ONLINE FIRST (FREE ACCESS) THE BRAIN IN THE LINE OF FIRE What's New in Intensive Care Hyperoxaemia in acute brain injured patients: too much of a good thing?Sekhon, M.S., Robba, C. & Young, P.J.  PERIOPERATIVE CARE IN THE ICU OPEN ACCESS ~ Review Intraoperative blood pressure management in noncardiac surgery: a narrative review based on current evidenceJoosten, A., Chew, M.S., Futier, E. et al. PHYSIOLOGY IN CRITICAL ILLNESS What's New in Inten...