Original Investigation  Gastroenterology and Hepatology Computer-Assisted Colonoscopy in High–Adenoma Detection Rate Settings in a High-Risk Population: A Randomized Clinical Trial Wen-Feng Hsu, Chen-Ya Kuo, Hsu-Heng Yen, et al JAMA Netw Open 2026;9;(4):e264881. doi:10.1001/jamanetworkopen.2026.4881 Key Points Question  Does the use of computer-aided detection (CAD) during colonoscopy improve adenoma dete...

Original Investigation  Surgery β-Lactam vs Non–β-Lactam Prophylaxis in Elective Colorectal Surgery Curtis D. Collins, Eric Hartsfield, Robert K. Cleary, et al JAMA Netw Open 2026;9;(4):e266708. doi:10.1001/jamanetworkopen.2026.6708 Key Points Question  Are surgical prophylaxis regimens containing β-lactam antibiotics associated with lower surgical site infections (SSIs) compared with non–β-lactam alternative regimens in patients undergoin...

Original Investigation  Health Informatics Large Language Model Performance and Clinical Reasoning Tasks Arya S. Rao, Kaiz P. Esmail, Richard S. Lee, et al JAMA Netw Open 2026;9;(4):e264003. doi:10.1001/jamanetworkopen.2026.4003 Key Points Question  Can off-the-shelf large language models (LLMs) demonstrate reliable performance across the clinical workflow? Findings  In this cross-sectional study of 21 frontier LLMs tested on ...

ORIGINAL ARTICLE Cefazolin for Methicillin-Susceptible Staphylococcus aureus Bacteremia The Staphylococcus aureus Network Adaptive Platform (SNAP) Trial Group N Engl J Med 2026;394:2329-2339 DOI: 10.1056/NEJMoa2506905 Abstract BACKGROUND Staphylococcus aureus bacteremia is associated with high mortality. Whether cefazolin or an antistaphylococcal penicillin should be preferred for the treatment of methicillin-susceptible S. aureus&...

Original Investigation  An American College of Surgeons National Quality Improvement Collaborative to Enhance Lung Cancer Surgical Quality Kelley Chan, Eileen M. Reilly, Ryan C. Jacobs, et al JAMA Surg Published Online: April 15, 2026 doi: 10.1001/jamasurg.2026.0902 Key Points Question  Can a national quality improvement (QI) collaborative model increase compliance for a lung cancer operative standard? Findings  Among 354 accr...

ONLINE FIRST (FREE ACCESS) PHYSIOLOGY IN CRITICAL ILLNESS Understanding the Disease Cardiac output and determinantsBhattacharjee, S., Ferrer, R. & Hamzaoui, O. LATEST ARTICLES Editorial Defining ECMO complications: a step towards improving clinical outcomes?Brown, A., Barbaro, R. Update on long-term physical disability after critical illness: the burden of post-intensive care syndromeHermann, M., Karner, V. & Schaller, S.J. Immunosuppressiv...

Original Investigation  Intrawound Tobramycin Plus Vancomycin to Prevent Surgical Site Infection in Tibial Fractures: The TOBRA Randomized Clinical Trial Major Extremity Trauma Research Consortium (METRC) JAMA Published online: April 15, 2026 doi: 10.1001/jama.2026.4023 Key Points Question  Is the combination of intrawound tobramycin and vancomycin powder more effective than vancomycin powder alone to reduce deep surgical site infection in...

ORIGINAL ARTICLE Selective Decontamination of the Digestive Tract in Adult Mechanically Ventilated Patients — An Updated Systematic Review with Bayesian Meta-Analysis Naomi E. Hammond, Anthony Devaux, Ruan Vlok, et al NEJM Evidence Published April 15, 2026 DOI: 10.1056/EVIDoa2500264 Abstract BACKGROUND There is uncertainty whether the use of selective decontamination of the digestive tract (SDD) as a preventive antimicrobial strategy reduces mortality...

Original Investigation  Caring for the Critically Ill Patient Gastric Residual Volume Assessment in Critically Ill Children: The GASTRIC-PICU Randomized Clinical Trial Lyvonne N. Tume, Paul R. Mouncey, Julia M. Broomhall, et al JAMA Published Online: June 12, 2026 doi: 10.1001/jama.2026.10639 Key Points Question  Is not routinely assessing gastric residual volume noninferior to regular assessment to guide enteral feeding in children wit...

ORIGINAL ARTICLE Prehospital Resuscitation with Type O Whole Blood for Trauma and Hemorrhage Jason L. Sperry, Francis X. Guyette, Bryan A. Cotton, et al N Engl J Med 2026;394:2317-2328 DOI: 10.1056/NEJMoa2602167 Abstract BACKGROUND Blood transfusion before arrival at a hospital reduces mortality from traumatic hemorrhage and shock. Whether transfusion with whole blood is more beneficial than transfusion with blood components is uncertain, as are the e...