Original Investigation Caring for the Critically Ill Patient 4% Tetrasodium EDTA to Prevent Central Venous Access Device–Associated Complications: A Randomized Clinical Trial Marlena Ornowska, Jessica Wittmann, Sandra Blitz, et al JAMA Published Online: May 18, 2026 doi: 10.1001/jama.2026.6025 Key Points Question  Can the use of 4% tetrasodium EDTA locking fluid decrease rates of central venous ac...

Original Investigation  Caring for the Critically Ill Patient Remote Multicomponent Rehabilitation in Intensive Care Unit Survivors: A Randomized Clinical Trial Brenda O’Neill, Judy M. Bradley, Bronwen Connolly, et al JAMA Published Online: May 18, 2026 doi: 10.1001/jama.2026.7401 Key Points Question  Does a remote multicomponent rehabilitation intervention improve quality of life in survivor...

Articles Oxygen saturation thresholds in children with acute respiratory distress (OxyKids): a multicentre, open, parallel-group, randomised clinical trial Sam Louman, Karlijn J van Stralen, Gerard H Koppelman, et al Lancet Respir Med Available online 12 May 2026 https://doi.org/10.1016/S2213-2600(26)00087-1 Summary Background Current peripheral oxygen saturation (SpO2) thresholds in children admitted to hospital with respiratory distress lack evidenc...

Articles Biological subphenotypes in severe acute hypoxaemic respiratory failure and acute respiratory distress syndrome using rapid prospective classification (SPARC) in the USA: a multicentre, observational, study D Clark Files, Michael A Matthay, Andrew G Chapple, et al Lancet Respir Med Available online 15 May 2026 https://doi.org/10.1016/S2213-2600(26)00083-4 Summary Background Two biological subphenotypes in acute respiratory distress syndrome (...

ONLINE FIRST (FREE ACCESS) OBESITY IN THE ICU OPEN ACCESS ~ Narrative Review Airway management in critically ill patients with obesityRussotto, V., Casey, J.D., Myatra, S.N. et al. LATEST ARTICLES OPEN ACCESS ~ Original The FICUS cluster randomized controlled trial of a family support intervention in adult intensive care units: mental health and family functioning outcomesRiguzzi, M., Jeitziner, MM., Rufer, M. et al. Effects of out-of-bed ar...

Articles Effects of inflammatory phenotypes in acute respiratory distress syndrome on mortality and partitioning of lung and chest wall mechanics in patients in the USA and Canada: a retrospective cohort study Joris Pensier, Maxime Fosset, Béla-Simon Paschold, et al Lancet Respir Med Available online 19 May 2026 https://doi.org/10.1016/S2213-2600(26)00045-7 Summary Background Inflammatory phenotypes of acute respiratory distress syndrome (ARDS) predic...

Reproducible clinical archetypes in acute respiratory failure: a multi-cohort trajectory analysis Marshall, D.C., Green, A.D., Komorowski, M. et al Intensive Care Med (2026) https://doi.org/10.1007/s00134-026-08441-2 Abstract Purpose Acute hypoxemic respiratory failure (AHRF) is common and biologically heterogeneous. Static phenotyping at a single time point does not capture illness evolution and risks stage-mixing; reproducible clinical course archetype...

Effects of out-of-bed armchair positioning on oxygenation in spontaneously breathing ICU patients receiving respiratory support: a randomized controlled trial Fossat, G., Muller, L., Seguin, A. et al. Intensive Care Med (2026). https://doi.org/10.1007/s00134-026-08453-y Abstract Purpose Comparing the effects of an out-of-bed armchair position versus an in-bed semi-recumbent position on oxygenation in spontaneously breathing intensive care unit (ICU) pati...

ONLINE FIRST (FREE ACCESS) THE BRAIN IN THE LINE OF FIRE What’s New in Intensive Medicine  Bridging the gap: pragmatic neuromonitoring and management of traumatic brain injury in resource-limited settingsRubiano, A.M., Loaiza-Cardona, L.M. & Videtta, W. LATEST ARTICLES Obituary Dr Rick van Saene 1946–2026Rommes, H., Petros, A., Zandstra, D. et al. Original Temporal trends and prognostic factors in critically ill adult patients with acute l...

ORIGINAL ARTICLE Early vasopressin administration in septic shock: A systematic review, meta-analysis, and multicenter retrospective observational study Chiwon Ahn, Gun Tak Lee, Jae Hwan Kim, et al Eur J Intern Med May 7, 2026 DOI: 10.1016/j.ejim.2026.106933 Abstract Objective To determine the optimal timing for initiating vasopressin in septic shock. Methods First, we performed a retrospective analysis of a multicenter regis...