ARTICLESVolume 405, Issue 10481P813-838March 08, 2025Open AccessDownload Full Issue Global, regional, and national prevalence of adult overweight and obesity, 1990–2021, with forecasts to 2050: a forecasting study for the Global Burden of Disease Study 2021 GBD 2021 Adult BMI Collaborators Lancet 2025; 405: 813-838 Summary Background Overweight and obesity is a global epidemic. Forecasting future trajectories of the epidemic is crucial for providing...

ONLINE FIRST (FREE ACCESS) Artificial Intelligence in ICU Collection Editorial Setting the ventilator with AI support: challenges and perspectives Fritsch S. J. & Cecconi M. Natural language processing in critical care: opportunities, challenges, and future directionsMcNicholas B. A., Madden M. G. & Laffey J. G. Using AI to detect and treat delirium Young M., Kotfis K. & Bellomo R. OPEN ACCESS ~ Editorial How AI can help in erro...

ARTICLESVolume 405, Issue 10481P785-812March 08, 2025 Global, regional, and national prevalence of child and adolescent overweight and obesity, 1990–2021, with forecasts to 2050: a forecasting study for the Global Burden of Disease Study 2021 GBD 2021 Adolescent BMI Collaborators Lancet 2025; 405: 785-812 Summary Background Despite the well documented consequences of obesity during childhood and adolescence and future risks of excess body mass on non-com...

Original Investigation  Pediatrics March 6, 2025 Trends in Respiratory Pathogen Testing at US Children’s Hospitals Matthew J. Molloy, Matthew Hall, Jessica L. Markham, et al JAMA Netw Open. 2025;8(3):e250160. doi:10.1001/jamanetworkopen.2025.0160 Key Points Question  How have respiratory pathogen testing rates and costs changed over time for children and adolescents with acute respiratory inf...

Original Investigation  March 5, 2025 Indocyanine Green Fluorescence Imaging in Prevention of Colorectal Anastomotic Leakage: A Randomized Clinical Trial Juha K. A. Rinne, Heikki Huhta, Tarja Pinta, et al JAMA Surg. Published online March 5, 2025. doi:10.1001/jamasurg.2025.0006 Key Points Question  Does the routine use of indocyanine green (ICG) fluorescence imaging decrease the rate of anastomo...

Original Investigation  March 3, 2025 Population-Scale Studies of Protein S Abnormalities and Thrombosis Sharjeel A. Chaudhry, Amelia K. Haj, Justine Ryu, et al JAMA. Published online March 3, 2025. doi:10.1001/jama.2025.0155 Key Points Question  What is the thrombosis risk conferred by deficiency in protein S? Findings  In this analysis of more than 600 000 individuals, we found th...

Original Investigation  March 3, 2025 Multivitamins After Myocardial Infarction in Patients With Diabetes: A Randomized Clinical Trial Francisco Ujueta, Gervasio A. Lamas, Kevin J. Anstrom, et al JAMA Intern Med. Published online March 3, 2025. doi:10.1001/jamainternmed.2024.8408 Key Points Question  In participants with diabetes and prior myocardial infarction (MI), do oral multivitamins and mu...

Original Investigation  January 13, 2025 Antiviral Medications for Treatment of Nonsevere Influenza: A Systematic Review and Network Meta-Analysis Ya Gao, Yunli Zhao, Ming Liu, et al JAMA Intern Med. 2025;185(3):293-301. doi:10.1001/jamainternmed.2024.7193 Key Points Question  What is the optimal antiviral drug in the treatment of patients with nonsevere influenza virus infection? Findings  I...

Extended treatment of venous thromboembolism with reduced-dose versus full-dose direct oral anticoagulants in patients at high risk of recurrence: a non-inferiority, multicentre, randomised, open-label, blinded endpoint trial Francis Couturaud, Jeannot Schmidt, Olivier Sanchez, et al Lancet 2025; 405: 725-735 Summary Background In patients with venous thromboembolism at high risk of recurrence for whom extended treatment with direct oral anticoagulants has ...

Research Letter  Physician Work Environment and Well-Being February 24, 2025 Trends in Physician Electronic Health Record Time and Message Volume A Jay Holmgren, Nate C. Apathy, Christine A. Sinsky, et al JAMA Intern Med. Published online February 24, 2025. doi:10.1001/jamainternmed.2024.8138 Physician work is increasingly centered around the electronic health record (EHR), which consumes nearly 50% of sc...