Research Letter  Nephrology March 5, 2025 Predicting Contrast-Associated Acute Kidney Injury Yunlin Feng, Min Jun, Amanda Y. Wang, et al JAMA Netw Open. 2025;8(3):e250107. doi:10.1001/jamanetworkopen.2025.0107 Introduction Contrast-associated acute kidney injury (CA-AKI), defined as AKI after exposure to a diagnostic or therapeutic radio-contrast agent,1 is an important clinical problem.2 CA-...

SPECIAL ARTICLE Association between Wealth and Mortality in the United States and Europe Sara Machado, Ilias Kyriopoulos, John Orav, et al N Engl J Med 2025;392:1310-1319 Abstract BACKGROUND Amid growing wealth disparity, we have little information on how health among older Americans compares with that among older Europeans across the distribution of wealth. METHODS We performed a longitudinal, retrospective cohor...

Original Investigation  Nephrology April 2, 2025 Cost-Effectiveness of Team-Based Coaching With Surveillance for Prevention of Acute Kidney Injuries David Xiao, Sharon E. Davis, Caroline M. Godfrey, et al JAMA Netw Open. 2025;8(4):e252503. doi:10.1001/jamanetworkopen.2025.2503 Key Points Question  What is the cost-effectiveness of interventions for implementing protocols for preventing contra...

Original Investigation  March 31, 2025 Inclusion of Retracted Studies in Systematic Reviews and Meta-Analyses of Interventions: A Systematic Review and Meta-Analysis Carolina Graña Possamai, Guillaume Cabanac, Elodie Perrodeau, et al JAMA Intern Med. Published online March 31, 2025. doi:10.1001/jamainternmed.2025.0256 Key Points Question  Do retracted studies impact results of systematic reviews...

Status of Sepsis Care in European Hospitals: Results from an International Cross-Sectional Survey Christian S. Scheer,  Evangelos J. Giamarellos-Bourboulis,  Ricard Ferrer, et al Am J Respir Crit Care Med Vol 211, Iss 4, pp 587–599, Apr 2025 DOI: 10.1164/rccm.202406-1167OC Abstract Rationale: Early detection, standardized therapy, adequate infrastructure, and strategies for quality improvement should constitute essential components of every hospital’s ...

Original Investigation  March 30, 2025 Cardiac Arrest During Long-Distance Running Races Jonathan H. Kim, Austin J. Rim, James T. Miller, et al JAMA. Published online March 30, 2025. doi:10.1001/jama.2025.3026 Key Points Question  What is the contemporary incidence of cardiac arrest and death among marathon and half-marathon runners in the US? Findings  In this case series and cohor...

Original Investigation  March 29, 2025 Prothrombin Complex Concentrate vs Frozen Plasma for Coagulopathic Bleeding in Cardiac Surgery: The FARES-II Multicenter Randomized Clinical Trial Keyvan Karkouti, Jeannie L. Callum, Justyna Bartoszko, et al JAMA. Published online March 29, 2025. doi:10.1001/jama.2025.3501 Key Points Question  Is prothrombin complex concentrate (PCC) efficacious and safe co...

Original Investigation  Critical Care Medicine March 28, 2025 Practical Anemia Bundle and Hemoglobin Recovery in Critical Illness: A Randomized Clinical Trial Matthew A. Warner, Matthew L. Johnson, Andrew C. Hanson, et al JAMA Netw Open. 2025;8(3):e252353. doi:10.1001/jamanetworkopen.2025.2353 Key Points Question  Does a multifaceted anemia prevention and treatment bundle vs standard care imp...

ARTIFICIAL INTELLIGENCE IN ICU Editorial Using AI to detect and treat delirium Young M., Kotfis K. & Bellomo R. LATEST ARTICLES Original ESICM consensus-based recommendations for the management of very old patients in intensive care Beil M., Alberto L., Bourne R. S., et al. Serum chloride concentration and outcomes in adults receiving intravenous fluid therapy with a balanced crystalloid solution or 0.9% sodium chloride Ramanan M., Hammond N...

Original Investigation  Oncology March 27, 2025 Late-Onset Immune-Related Adverse Events After Immune Checkpoint Inhibitor Therapy Sienna M. Durbin, Leyre Zubiri, Katherine Perlman, et al JAMA Netw Open. 2025;8(3):e252668. doi:10.1001/jamanetworkopen.2025.2668 Key Points Question  What is the frequency of late-onset immune-related adverse events (irAEs) among patients treated with immune chec...