Evaluating culture-free targeted next-generation sequencing for diagnosing drug-resistant tuberculosis: a multicentre clinical study of two end-to-end commercial workflows Rebecca E Colman, Marva Seifert, Andres De la Rossa, et al Lancet Infect Dis Available online 29 October 2024 https://doi.org/10.1016/S1473-3099(24)00586-3 Summary Background Drug-resistant tuberculosis remains a major obstacle in ending the global tuberculosis epidemic. Deployment of ...

The prevalence of hypoxaemia in paediatric and adult patients in health-care facilities in low-income and middle-income countries: a systematic review and meta-analysis Hamish R Graham, Esrat Jahan, Rami Subhi, et al Lancet Global Health 2025; 13: e222-e231 https://doi.org/10.1016/S2214-109X(24)00469-8 Summary Background Hypoxaemia (low oxygen saturation in blood) is a key predictor of in-hospital mortality, affecting people of all ages with many differe...

Effectiveness of 2023 southern hemisphere influenza vaccines against severe influenza-associated illness: pooled estimates from eight countries using the test-negative design Radhika Gharpure, Annette K Regan, Francisco Nogareda, et al Lancet Global Health 2025; 13: e203-e211 https://doi.org/10.1016/S2214-109X(24)00473-X Summary Background Annual estimates of seasonal influenza vaccine effectiveness can guide global risk communication and vaccination str...

Prevalence, aetiology, and hospital outcomes of paediatric acute critical illness in resource-constrained settings (Global PARITY): a multicentre, international, point prevalence and prospective cohort study Teresa B Kortz, Adrian Holloway, Asya Agulnik, et al Lancet Global Health 2025; 13: e212-e221 https://doi.org/10.1016/S2214-109X(24)00450-9 Summary Background Children in resource-constrained settings (RCS) have disproportionately high illness and mo...

Safety and efficacy of nipocalimab in adults with generalised myasthenia gravis (Vivacity-MG3): a phase 3, randomised, double-blind, placebo-controlled study Carlo Antozzi, Tuan Vu, Sindhu Ramchandren, et al Lancet Neurol 2025; 24: 105-116 https://doi.org/10.1016/S1474-4422(24)00498-8 Summary Background Given burdensome side-effects and long latency for efficacy with conventional agents, there is a continued need for generalised myasthenia gravis treatme...

Effectiveness of ceftazidime–avibactam versus ceftolozane–tazobactam for multidrug-resistant Pseudomonas aeruginosainfections in the USA (CACTUS): a multicentre, retrospective, observational study Ryan K Shields, Lilian M Abbo, Renee Ackley, et al Lancet Infect Dis Available online 16 December 2024 https://doi.org/10.1016/S1473-3099(24)00648-0 Summary Background Ceftolozane–tazobactam and ceftazidime–avibactam are preferred treatment options for multidru...

Global, regional, and national age-sex-specific burden of diarrhoeal diseases, their risk factors, and aetiologies, 1990–2021, for 204 countries and territories: a systematic analysis for the Global Burden of Disease Study 2021 GBD 2021 Diarrhoeal Diseases Collaborators Lancet Infectious Diseases Available online 18 December 2024 https://doi.org/10.1016/S1473-3099(24)00691-1 Summary Background Diarrhoeal diseases claim more than 1 million lives annually and...

Robust Meta-Model for Predicting the Likelihood of Receiving Blood Transfusion in Non-traumatic Intensive Care Unit Patients ALIREZA RAFIEI , RONALD MOORE, TILENDRA CHOUDHARY, et al HEALTH DATA SCIENCE 2024; 4: 0197 DOI: 10.34133/hds.0197 Abstract Background: Blood transfusions, crucial in managing anemia and coagulopathy in intensive care unit (ICU) settings, require accurate prediction for effective resource allocation and patient risk assessment. However...

Original Investigation  January 29, 2025 Benzodiazepine-Free Cardiac Anesthesia for Reduction of Postoperative Delirium: A Cluster Randomized Crossover Trial Jessica Spence, P. J. Devereaux, Shun-Fu Lee, et al JAMA Surg. Published online January 29, 2025 doi:10.1001/jamasurg.2024.6602 Key Points Question  Does an institutional policy restricting benzodiazepines during cardiac anesthesia reduc...

Research Letter  January 27, 2025 Cardiac Biomarker Testing in US Emergency Departments Cian P. McCarthy, Nathan W. Watson, Jason H. Wasfy, et al JAMA Intern Med. Published online January 27, 2025. doi:10.1001/jamainternmed.2024.7554 Patient characteristics and presenting symptoms are used in risk stratification for individuals evaluated in the emergency department (ED) as to their likelihood of having acute...