Original Investigation  Critical Care Medicine March 21, 2025 External Validation of the Phoenix Sepsis Score in Children With Suspected Community-Acquired Sepsis Elliot Long, Meredith L. Borland, Shane George, et al JAMA Netw Open. 2025;8(3):e251412. doi:10.1001/jamanetworkopen.2025.1412 Key Points Question  How do the Phoenix Sepsis Score and sepsis criteria perform in an external dataset? ...

Original Investigation  Infectious Diseases March 21, 2025 Seven vs Fourteen Days of Antibiotics for Gram-Negative Bloodstream Infection: A Systematic Review and Noninferiority Meta-Analysis Todd C. Lee, Connor J. Prosty, Michael Fralick, et al JAMA Netw Open. 2025;8(3):e251421. doi:10.1001/jamanetworkopen.2025.1421 Key Points Question  Are 7 days of antibiotic therapy adequate for the treatm...

riginal Investigation  Health Policy March 19, 2025 Complex Sepsis Presentations, SEP-1 Compliance, and Outcomes Chanu Rhee, Sarah E. Train, Michael R. Filbin, et al JAMA Netw Open. 2025;8(3):e251100. doi:10.1001/jamanetworkopen.2025.1100 Key Points Question  Are sepsis presentations associated with Severe Sepsis and Septic Shock Management Bundle (SEP-1) compliance and mortality? Findings...

Original Investigation  January 15, 2025 Safety and Efficacy of Tranexamic Acid in General Surgery Lily J. Park, Maura Marcucci, Sandra N. Ofori, et al JAMA Surg. Published online January 15, 2025. doi:10.1001/jamasurg.2024.6048 Key Points Question  What is the safety and efficacy profile of prophylactic tranexamic acid (TXA) use in general surgery? Findings  In this substudy of a r...

Research Safety of inpatient care in surgical settings: cohort study Antoine Duclos, Michelle L Frits, Christine Iannaccone, et al BMJ 2024; 387 doi: https://doi.org/10.1136/bmj-2024-080480 (Published 13 November 2024)Cite this as: BMJ 2024;387:e080480 Abstract Objectives To estimate the frequency, severity, and preventability of adverse events associated with perioperative care, and to describe the setting and professions concerned. Design Mul...

Original Investigation  Infectious Diseases March 14, 2025 Antimicrobial-Resistant Infections in Hospitalized Patients Hannah Wolford, Natalie L. McCarthy, James Baggs, et al JAMA Netw Open. 2025;8(3):e2462059. doi:10.1001/jamanetworkopen.2024.62059 Key Points Question  How has antimicrobial resistance changed from 2012 to 2022? Findings  In this cohort study of 7 158 139 culture...

Original Investigation  Infectious Diseases March 14, 2025 Probiotics and Fever Duration in Children With Upper Respiratory Tract Infections: A Randomized Clinical Trial Silvia Bettocchi, Anna Comotti, Marina Elli, et al JAMA Netw Open. 2025;8(3):e250669. doi:10.1001/jamanetworkopen.2025.0669 Key Points Question  Does a probiotic mixture containing Bifidobacterium breve M-16V, ...

Original Investigation Emergency Medicine March 14, 2025 Therapy Dogs for Anxiety in Children in the Emergency Department: A Randomized Clinical Trial Heather P. Kelker, Huma K. Siddiqui, Alan M. Beck, et al JAMA Netw Open. 2025;8(3):e250636. doi:10.1001/jamanetworkopen.2025.0636 Key Points Question  Can adjunctive use of therapy dogs in child-life therapy reduce both child-reported anxiety and pa...

Original Investigation  January 27, 2025 Negative Pressure Dressings to Prevent Surgical Site Infection After Emergency Laparotomy: The SUNRRISE Randomized Clinical Trial SUNRRISE Trial Study Group JAMA. 2025;333(10):853-863. doi:10.1001/jama.2024.24764 Key Points Question  Among patients undergoing emergency laparotomy, is there a difference in surgical site infection (SSI) rates when the wound is treated with incisional negative pre...

Original Investigation  March 10, 2025 Awake Prone Positioning in Adults With COVID-19: An Individual Participant Data Meta-Analysis Jian Luo, Ivan Pavlov, Elsa Tavernier, et al JAMA Intern Med. Published online March 10, 2025. doi:10.1001/jamainternmed.2025.0011 Key Points Question  Is awake prone positioning (APP) associated with better odds of survival without intubation compared with supine ...