Articles Predicting bloodstream infection by plasma cell-free metagenomic sequencing: a prospective cohort study Joshua Wolf, Kathryn P Goggin, Yuki Inaba, et al Lancet Microbe 2026; 7: 101312 https://doi.org/10.1016/j.lanmic.2025.101312 Summary Background Patients receiving myelosuppressive chemotherapy or haematopoietic cell transplantation are at high risk for life-threatening bloodstream infections. A novel pre-emptive treatment paradigm guided by...

Articles Invasive aspergillosis in liver transplant recipients in France (2007–21): a nationwide, retrospective, matched case–control study Coralie Le Hyaric, Cléa Melenotte, François Lefebvre, et al Lancet Microbe 2026; 7: 101272 https://doi.org/10.1016/j.lanmic.2025.101272  Summary Background Invasive aspergillosis is a rare but severe complication of liver transplantation. Incidence varies from 1·2% to 5·6% and mortality is greater than 50%. Few st...

ORIGINAL ARTICLE Oral Nirmatrelvir–Ritonavir for Covid-19 in Higher-Risk Outpatients Christopher C. Butler, Andrew D. Pinto, Victoria Harris, et al N Engl J Med 2026;394:1583-1594 DOI: 10.1056/NEJMoa2502457 Abstract BACKGROUND Nirmatrelvir–ritonavir has been shown to reduce progression to severe illness from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in unvaccinated high-risk outpatients. The effectiveness of nirmatrelvir–ritonavir i...

Original Investigation  Lung Transplant for Refractory Lung-Limited Stage IV Non–Small Cell Lung Cancer Ankit Bharat, Chitaru Kurihara, Liam IL-Young Chung, et al JAMA Published Online: July 8, 2026 doi: 10.1001/jama.2026.8717 Key Points Question  Among selected adults with medically refractory, lung-limited, stage IV non–small cell lung cancer (NSCLC), what are the outcomes with lung transplant and how does early overall survival compare ...

Original Investigation  Infectious Diseases Pharmacokinetics of Dalbavancin in Complicated Staphylococcus aureus Bacteremia: A Secondary Analysis of the DOTS Randomized Clinical Trial Thomas P. Lodise, Nicholas A. Turner, Toshimitsu Hamasaki, et al JAMA Netw Open 2026;9;(4):e2611652. doi:10.1001/jamanetworkopen.2026.11652 Key Points Question  What are the pharmacokinetics of a 2-dose dalbavancin regimen used for consolidation therapy in co...

Original Investigation  Dalbavancin for Treatment of Staphylococcus aureus Bacteremia: The DOTS Randomized Clinical Trial Nicholas A. Turner, Toshimitsu Hamasaki, Sarah B. Doernberg, et al JAMA 2025;334;(10):866-877. doi:10.1001/jama.2025.12543 Key Points Question  Is dalbavancin a superior treatment option for complicated Staphylococcus aureus bacteremia compared with standard care? F...

Research Non-drug perioperative interventions to reduce postoperative pulmonary complications after abdominal surgery: systematic review and meta-analysis Chanyan Huang, Xu Zhao, Siyu Geng, et al BMJ 2026; 393 doi: https://doi.org/10.1136/bmj-2025-089001 (Published 09 April 2026)Cite this as: BMJ 2026;393:e089001 Abstract Objective To evaluate the effectiveness of perioperative non-drug interventions in reducing postoperative pulmonary complications (P...

Original Investigation  Fecal Microbiota Transplant and Multidrug-Resistant Organism Decolonization in Gastrointestinal Disease: A Randomized Clinical Trial Himanshu Narang, Daizee Talukdar, Bipul Kumar, et al JAMA Intern Med Published Online: April 20, 2026 doi: 10.1001/jamainternmed.2026.0655 Key Points Question  Is fecal microbiota transplant (FMT) effective in achieving gut decolonization of...

Original Investigation  Fast Antimicrobial Susceptibility Testing for Gram-Negative Bacteremia: The FAST Randomized Clinical Trial Ritu Banerjee, Lauren Komarow, Yixuan Li, et al JAMA Published Online: April 18, 2026 doi: 10.1001/jama.2026.5487 Key Points Question  Does use of rapid antimicrobial susceptibility testing directly from blood culture bottles positive for gram-negative bacteria impro...

Original Investigation  Amoxicillin-Clavulanate vs Amoxicillin for Acute Sinusitis in Adults Timothy J. Savage, Anne M. Butler, Matthew P. Kronman, et al JAMA Published Online: April 18, 2026 doi: 10.1001/jama.2025.26902 Key Points Question  For acute sinusitis in adults younger than 65 years, is standard-dose amoxicillin-clavulanate associated with different risks of treatment failure and adver...