Original Investigation  Caring for the Critically Ill Patient Isoflurane-Based Inhaled Sedation in Mechanically Ventilated Adults With Acute Hypoxemic Respiratory Failure: The SAVE-ICU Randomized Clinical Trial Angela Jerath, Marat Slessarev, Claudio Martin, et al JAMA Published Online: October 14, 2026 doi: 10.1001/jama.2026.18471 Key Points Question  Among mechanically ventilated adult patients with acute hypoxemic respiratory failure...

Critical Care: Research Letter Efficacy and Safety of Landiolol in Patients With Cardiogenic Shock Giovanni Tavecchia, Guido Tavazzi, Giovanna Viola, et al Chest Available online 25 March 2026 https://doi.org/10.1016/j.chest.2026.02.034 To the Editor: Although compensatory tachycardia represents a normal physiologic response in patients with cardiogenic shock (CS), the presence of tachyarrhythmias (including disproportionate sinus tachycardia) can advers...

Original Investigation  Outcomes and Costs After Robotic vs Laparoscopic Complex Elective Cholecystectomy Katharine E. Caldwell, Edie Threlkeld, Joseph Litrel, et al JAMA Surg 2026 Sep 1;161(9):909-915. doi: 10.1001/jamasurg.2026.2650 Key Points Question  Is a robotic approach associated with improved clinical outcomes and equivalent total cost compared with a laparoscopic approach for patients undergoing comp...

Research Comparative effects of drugs for adults with overweight or obesity: systematic review and network meta-analysis Kailei Nong, Qingyang Shi, Xinran Xie, et al BMJ 2026; 394 doi: https://doi.org/10.1136/bmj-2026-372161 (Published 08 July 2026)Cite this as: BMJ 2026;394:e372161 Abstract Objective To provide an up-to-date evidence summary about the comparative benefits and harms of drugs for adults with overw...

Research Robotic versus Open Pancreatoduodenectomy (PORTAL): multicentre, single masked, phase 3, non-inferiority randomised controlled trial Jiabin Jin, Kai Qin, Georgios Gemenetzis, t al BMJ 2026; 394 doi: https://doi.org/10.1136/bmj-2026-319692 (Published 01 July 2026)Cite this as: BMJ 2026;394:e319692 Abstract Objective To determine whether robotic pancreatoduodenectomy (RPD) is non-inferior to open pancreatoduodenectomy (OPD) in terms of postopera...

Articles Standard-dose unfractionated heparin versus low-dose unfractionated heparin and low-molecular-weight heparin in extracorporeal life support (RATE): an open-label, randomised, non-inferiority trial Olivier van Minnen, Annemieke Oude Lansink-Hartgring, Rombout B E van Amstel, et al Lancet Available online 7 July 2026 https://doi.org/10.1016/S0140-6736(26)00851-2 Summary Background In patients receiving extracorporeal membrane oxygenation (ECMO)...

Research Assessing early effects of Australia’s Social Media Minimum Age Act on adolescents’ social media use: observational study ourtney Barnes, Alix Hall, Stephanie Mantach, et al BMJ 2026; 393 doi: https://doi.org/10.1136/bmj-2026-363695 (Published 24 June 2026)Cite this as: BMJ 2026;393:e363695 Abstract Objectives To examine the early effect of a world first national policy (Social Media Minimum Age Act 2024, which established a national minimum a...

Articles Temocillin versus carbapenems for bacteraemia due to third-generation cephalosporin-resistant Enterobacterales in Spain (ASTARTÉ): a multicentre, phase 3, open-label, non-inferiority, randomised clinical trial Francesco Cogliati Dezza, Lydia Barrera Pulido, Irene Borreguero Borreguero, et al Lancet Available online 9 July 2026 https://doi.org/10.1016/S0140-6736(26)00760-9 Summary Background Alternatives to carbapenems for the treatment of thi...

Original Investigation  Formulary-Related Insurance Denials of Single-Source Branded Drugs in the United States Joseph F. Levy, G. Caleb Alexander, Boris Vabson, et al JAMA Published Online: July 9, 2026 doi: 10.1001/jama.2026.8702 Key Points Question  How frequently are prescriptions rejected because of insurance formulary restrictions in the United States, and how often are the rejected medicines u...

Article Early high-dose vitamin C for out-of-hospital cardiac arrest: the VITaCCA randomized clinical trial Rozemeijer, S., Dubois, E.A., de Grooth, HJ. et al Intensive Care Med 52, 1447–1457 (2026) https://doi.org/10.1007/s00134-026-08492-5 Abstract Background Besides temperature management, there is currently no effective therapy to decrease the burden of post-cardiac arrest syndrome. The pleiotropic effects of vitamin C may improve clinical outcome...