Original Investigation  Antibiotic Therapy for Uncomplicated Acute Appendicitis: Ten-Year Follow-Up of the APPAC Randomized Clinical Trial Paulina Salminen, Roosa Salminen, Johanna Kallio, et al JAMA Published Online: January 21, 2026 doi: 10.1001/jama.2025.25921 Key Points Question  What is the long-term appendicitis recurrence and appendectomy rate in adult patients with uncomplicated acute ap...

Original Investigation  Infectious Diseases Single-Dose Liposomal Amphotericin Plus Fluconazole and Flucytosine for Cryptococcal Meningitis at a US Public Hospital Devin Clark, Javier Barranco-Trabi, Irene Goo, et al JAMA Netw Open 2026;9;(1):e2553552. doi:10.1001/jamanetworkopen.2025.53552 Key Points Question  What are the outcomes of the AMBITION protocol (single-dose liposomal amphotericin with 2 weeks of f...

Research Weight regain after cessation of medication for weight management: systematic review and meta-analysis Sam West, Jadine Scragg, Paul Aveyard, et al BMJ 2026; 392 doi: https://doi.org/10.1136/bmj-2025-085304 (Published 07 January 2026)Cite this as: BMJ 2026;392:e085304 Abstract Objectives To quantify and compare the rate of weight regain after cessation of weight management medications (WMMs) in adults wi...

Research Letter  Impact of a Smartwatch Hypertension Notification Feature for Population Screening Jordana B. Cohen, Daniel K. Addo, Joshua A. Jacobs, et al JAMA 2026;335;(11):1001-1003. doi:10.1001/jama.2025.26925 In September 2025, the US Food and Drug Administration cleared the Apple Watch hypertension notification feature, which uses photoplethysmography signals to notify users of possible hypertension without using ...

Original Investigation  Coffee and Tea Intake, Dementia Risk, and Cognitive Function Yu Zhang, Yuxi Liu, Yanping Li, et al JAMA 2026;335;(11):961-974. doi:10.1001/jama.2025.27259 Key Points Question  Is long-term intake of caffeinated and decaffeinated coffee associated with risk of dementia and cognitive outcomes? Findings  In this prospective cohort study of 131 821 individuals from 2 cohorts ...

Original Investigation  Caring for the Critically Ill Patient Respiratory Gas Shifts to Delay Asphyxiation in Critical Avalanche Burial: A Randomized Clinical Trial Frederik Eisendle, Giulia Roveri, Simon Rauch, et al JAMA 2025;334;(19):1720-1727 doi:10.1001/jama.2025.16837 Key Points Question  Does a novel device delay the onset of hypoxemia and hypercapnia during critical avalanche burial by enhancing air...

Original Investigation  Whole-Blood vs Component Therapy in Adult Trauma: An Updated Systematic Review and Meta-Analysis Wesam Ibrahim, Kenneth Meza Monge, Johannes Menzel, et al JAMA Surg Published Online: March 11, 2026 doi: 10.1001/jamasurg.2026.0197 Key Points Question  Is whole-blood transfusion associated with reduced mortality compared with component therapy in adult trauma patients? F...

Research Letter  Health Policy Early Morning Blood Draw Timing and Frequency Among Hospitalized Patients Michael Colacci, Anne Loffler, Surain B. Roberts, et al JAMA Netw Open 2026;9;(3):e260966. doi:10.1001/jamanetworkopen.2026.0966 Introduction Hospitalized patients report less sleep in the hospital and an increased number of nocturnal awakenings, which has been associated with the development of delirium.1,2&nbs...

Original Investigation  Pediatrics Smartphone Use During School Hours and Association With Cognitive Control in Youths Aged 11 to 18 Years Eva H. Telzer, Kaitlyn Burnell JAMA Netw Open 2026;9;(3):e261092. doi:10.1001/jamanetworkopen.2026.1092 Key Points Questions  How much are youths using their smartphones during school instruction time, and what is the association of this use with cognitive control? Findings &...

Original Investigation  Pediatrics High-Frequency Oscillation vs Mechanical Ventilation for Neonatal Acute Respiratory Distress Syndrome: A Randomized Clinical Trial Jie Li, Kaizhen Liu, Qian Yang, et al JAMA Netw Open 2026;9;(3):e260268. doi:10.1001/jamanetworkopen.2026.0268 Key Points Question  Does elective high-frequency oscillatory ventilation (HFOV) reduce the incidence of bronchopulmonary dysplasia...