Original Investigation  Infectious Diseases Health Care–Associated Infections Among Neonates During the COVID-19 Pandemic Sagori Mukhopadhyay, Mark Conaway, Miren B. Dhudasia, et al JAMA Netw Open 2026;9;(1):e2555623. doi:10.1001/jamanetworkopen.2025.55623 Key Points Question  Did health care–associated infection (HAI) in neonatal intensive care units (NICUs) decrease with enhanced infection prevention measure...

Original Investigation  Hematology Platelet Transfusion Practices and Outcomes in Neonates and Children Ruchika Goel, Oliver Karam, Donald E. Warden, et al JAMA Netw Open 2026;9;(1):e2554531. doi:10.1001/jamanetworkopen.2025.54531 Key Points Question  What is the epidemiology of platelet transfusions in pediatric and neonatal recipients, and are donor and platelet processing factors associated with posttr...

Research The impact of skin tone on performance of pulse oximeters used by NHS England COVID Oximetry @home scheme: measurement and diagnostic accuracy study Daniel S Martin, James C Doidge, Doug Gould, et al BMJ 2026; 392 doi: https://doi.org/10.1136/bmj-2025-085535 (Published 14 January 2026)Cite this as: BMJ 2026;392:e085535 Abstract Objectives To assess the impact of skin tone on the measurement and diagnostic accuracy of five fingertip pulse oxime...

Articles Deaths potentially averted by small changes in physical activity and sedentary time: an individual participant data meta-analysis of prospective cohort studies Ulf Ekelund, Jakob Tarp, Ding Ding, et al Lancet 2026; 407: 339-349 https://doi.org/10.1016/S0140-6736(25)02219-6 Summary Background The effects of small, realistic changes in physical activity and sedentary behaviour on population-level mortality are unclear. We aimed to estimate the ...

PERIOPERATIVE MEDICINE Individualized Flow-controlled versus Pressure-controlled Ventilation in Cardiac Surgery: A Randomized Controlled Trial Becker, Simon; Kurz, Christian T; Schnitzler, Romina, et al Anesthesiology January 14, 2026. | DOI: 10.1097/ALN.0000000000005851 Background:  Patients undergoing on-pump cardiac surgery are at high risk for perioperative lung injury and a hyperinflammatory state associated with postoperative complications. The a...

ARTICLES Online firstMarch 16, 2026 Epidemiology, ventilation, and outcomes of acute respiratory failure in immunocompromised patients from 103 intensive care units in 26 countries: a retrospective observational study Elie Azoulay, Colleen McEvoy, Pedro Castro, et al Lancet Respir Med Published March 16, 2026 DOI: 10.1016/S2213-2600(26)00046-9  Summary Background Acute hypoxaemic respiratory failure (ARF) is the leading cause of intensive care unit (I...

ORIGINAL ARTICLE High-Flow or Standard Oxygen in Acute Hypoxemic Respiratory Failure Jean-Pierre Frat, Jean-Pierre Quenot, Christophe Guitton, et al N Engl J Med Published March 17, 2026 Abstract BACKGROUND Data are needed on the effect of oxygen delivered through a high-flow nasal cannula, as compared with standard oxygen therapy, on intubation and mortality in patients with acute hypoxemic respiratory failure. METHODS In this multicenter, open-la...

ORIGINAL ARTICLE Bleeding Risk with Apixaban vs. Rivaroxaban in Acute Venous Thromboembolism Lana A. Castellucci, Vivien M. Chen, Michael J. Kovacs, et al N Engl J Med 2026;394:1051-1060 DOI: 10.1056/NEJMoa2510703 Abstract BACKGROUND Apixaban and rivaroxaban are the oral anticoagulants most frequently used to treat acute venous thromboembolism. However, uncertainty remains about the difference in bleeding risk between the two medications. METHODS ...

ORIGINAL ARTICLE Prehospital Whole Blood in Traumatic Hemorrhage — a Randomized Controlled Trial Jason E. Smith, Rebecca Cardigan, Emily Sanderson, et al N Engl J Med Published March 17, 2026 DOI: 10.1056/NEJMoa2516043 Abstract BACKGROUND Whole-blood transfusion has recently gained favor in the management of severe hemorrhage; however, data from large clinical trials evaluating its clinical effectiveness and safety are lacking. METHODS We conduc...

Critical Care in an Age of War In ICU Tue, 17 Mar 2026 Conflict is no longer a distant concern; it is edging ever closer to the hospital ward. From cyberattacks on healthcare systems to fragile global supply chains and the realities of modern warfare, intensive care and emergency medicine specialists are being forced to reconsider how their units would function in a crisis. During ISICEM’s morning session, Prof Alexander Vlaar delivered a clear warn...