Article The environmental cost of learning: CO2 emission comparisons of virtual reality, online, and alternative distance education Istrate, G.M., Van Gelder, F., Szőllősi, G.J. et al Intensive Care Med (2026). https://doi.org/10.1007/s00134-026-08460-z Abstract Purpose Environmental sustainability has become a critical concern across various sectors, including education and healthcare. Professional training programmes, particularly in intensive care med...

Article Personalized automatic management of tracheal cuff pressure and subglottic secretions drainage to prevent pneumonia in critically ill intubated patients. The MICROINHALO multicenter randomized controlled trial De Pascale, G., Cutuli, S.L., Vargas, M. et al Intensive Care Med (2026). https://doi.org/10.1007/s00134-026-08459-6 Abstract Purpose: The MICROINHALO trial investigated whether personalized management of endotracheal tube cuff pressure (...

Original Investigation  Surgeon Social Jet Lag and Patient Risk of Major Adverse Events Léa Pascal, Stéphanie Polazzi, Sarah C. Skinner, et al JAMA Surg Published Online: June 3, 2026 doi: 10.1001/jamasurg.2026.1796 Key Points Question  Is surgeon sleep timing regularity associated with patient outcomes? Findings  In this multispecialty cohort study including 7117 operations perform...

Original Investigation  Infectious Diseases Multicenter Validation of Clinical Sepsis Phenotypes Chang Ho Yoon, Daniel Sjöholm, Kristin E. Wickstrøm, et al JAMA Netw Open 2026;9;(6):e2616134. doi:10.1001/jamanetworkopen.2026.16134 Key Points Question  Are the 4 clinical phenotypes of sepsis derived from Sepsis Endotyping in Emergency Care (SENECA) data generalizable across independent, international patie...

Research Concordance between target trial emulation and randomised controlled trials: systematic review and meta-analysis Canlong Wang, Dongfeng Tang, Peter von Dadelszen, et al BMJ 2026; 393 doi: https://doi.org/10.1136/bmj-2025-086810 (Published 19 May 2026)Cite this as: BMJ 2026;393:e086810 Abstract Objectives To assess the concordance of results between paired target trial emulations and their benchmarking randomised controlled trials and to explor...

Article Impact of appropriate antimicrobial therapy on patient outcomes and antimicrobial use: a sub analysis of the DIANA Study Dataset Cidade, J.P., Póvoa, P., Depuydt, P. et al Intensive Care Med (2026) https://doi.org/10.1007/s00134-026-08448-9 Abstract Objective Although inappropriate therapy has been consistently associated with adverse outcomes, the magnitude and consistency of the benefit associated with appropriate empiric therapy in cri...

ONLINE FIRST (FREE ACCESS) LATEST ARTICLES Original The environmental cost of learning: CO2 emission comparisons of virtual reality, online, and alternative distance educationIstrate, G.M., Van Gelder, F., Szőllősi, G.J. et al. Impact of appropriate antimicrobial therapy on patient outcomes and antimicrobial use: a sub analysis of the DIANA Study DatasetCidade, J.P., Póvoa, P., Depuydt, P. et al. OPEN ACCESS ~ Original Personalized automatic managem...

ORIGINAL ARTICLE Ultrasound-Facilitated, Catheter-Directed Fibrinolysis for Acute Pulmonary Embolism Kenneth Rosenfield, Frederikus A. Klok, Gregory Piazza, et al N Engl J Med 2026;394:1979-1990 DOI: 10.1056/NEJMoa2516567 Abstract BACKGROUND Whether anticoagulation alone is an adequate treatment for acute, intermediate-risk pulmonary embolism is uncertain. METHODS We conducted a multinational, adaptive-design t...

Research Letter  Comparative Safety of Robotic-Assisted vs Laparoscopic Cholecystectomy in Contemporary Practice Cody Lendon Mullens, Eunice Y. Lee, Jyothi R. Thumma, et al JAMA Surg Published Online: May 27, 2026 doi: 10.1001/jamasurg.2026.1585 Robotic-assisted cholecystectomy has expanded rapidly in the US and is thought to now comprise one-quarter of cholecystectomies.1 Prior work has identified an associ...

Original Investigation Caring for the Critically Ill Patient 4% Tetrasodium EDTA to Prevent Central Venous Access Device–Associated Complications: A Randomized Clinical Trial Marlena Ornowska, Jessica Wittmann, Sandra Blitz, et al JAMA Published Online: May 18, 2026 doi: 10.1001/jama.2026.6025 Key Points Question  Can the use of 4% tetrasodium EDTA locking fluid decrease rates of central venous ac...