Articles A preventive care strategy to reduce moderate or severe acute kidney injury after major surgery (BigpAK-2); a multinational, randomised clinical trial Alexander Zarboci, Marlies Ostermann, Lui Forni, et al Lancet 2025; 406: 2787-2791 https://doi.org/10.1016/S0140-6736(25)01717-9 Summary Background Acute kidney injury (AKI) is a common and important complication of major surgery, yet recommended preventive care is rarely administered. We used ...

Research Christmas 2025:  Changes in diversity language in National Institutes of Health grant awards: observational study Neil Mehta, Anupam B Jena, Joseph P Newhouse BMJ 2025; 391 doi: https://doi.org/10.1136/bmj-2025-087222 (Published 11 December 2025)Cite this as: BMJ 2025;391:e087222 Abstract Objective To assess changes in the prevalence of diversity language in National Institutes of Health (NIH) grants in 2024-25. Design Retros...

Research Christmas 2025: Words and meanings How recent is recent? Retrospective analysis of suspiciously timeless citations Alejandro Díez-Vidal, Jose R Arribas BMJ 2025; 391 doi: https://doi.org/10.1136/bmj-2025-086941 (Published 11 December 2025)Cite this as: BMJ 2025;391:e086941 Abstract Objective To quantify the time lag between biomedical articles and the studies they describe as “recent,” a term widely used to imply timeliness despite rarely...

ORIGINAL ARTICLE Ketamine or Etomidate for Tracheal Intubation of Critically Ill Adults Jonathan D. Casey, Kevin P. Seitz, Brian E. Driver, et al N Engl J Med Published December 9, 2025 DOI: 10.1056/NEJMoa2511420 Abstract BACKGROUND For critically ill adults undergoing tracheal intubation, observational studies suggest that the use of etomidate to induce anesthesia may increase the risk of death. Whether the use of ketamine rather than etomidate decre...

Original Investigation  Infectious Diseases Syndromic Analysis of Sepsis Cohorts Using Large Language Models Theodore R. Pak, Sanjat Kanjilal, Caroline S. McKenna, et al JAMA Netw Open 2025;8;(10):e2539267. doi:10.1001/jamanetworkopen.2025.39267 Key Points Question  Can large language models (LLMs) accurately extract presenting signs and symptoms from clinical notes to identify associations between sympto...

ORIGINAL ARTICLE A Phase 3 Trial of Telitacicept for Systemic Lupus Erythematosus Ronald F. van Vollenhoven, Li Wang, Joan T. Merrill, et al N Engl J Med 2025;393:1475-1485 DOI: 10.1056/NEJMoa2414719 Abstract BACKGROUND Telitacicept, a new dual inhibitor of the cytokines B-lymphocyte stimulator (BLyS) and APRIL (a proliferation-inducing ligand), showed efficacy in adults with active systemic lupus erythematosus (SLE) in a phase 2b trial when added to ...

ARTICLES Global age-sex-specific all-cause mortality and life expectancy estimates for 204 countries and territories and 660 subnational locations, 1950–2023: a demographic analysis for the Global Burden of Disease Study 2023 GBD 2023 Demographics Collaborators Lancet 2025; 406: 1731-1810 DOI: 10.1016/S0140-6736(25)01330-3  Summary Background Comprehensive, comparable, and timely estimates of demographic metrics—including life expectancy and...

ARTICLES Burden of 375 diseases and injuries, risk-attributable burden of 88 risk factors, and healthy life expectancy in 204 countries and territories, including 660 subnational locations, 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023 GBD 2023 Disease and Injury and Risk Factor Collaborators Lancet 2025; 406: 1873-1922 DOI: 10.1016/S0140-6736(25)01637-X Summary Background For more than three decades, the Global Bur...

Original Investigation  Caring for the Critically Ill Patient Cryopreserved vs Liquid-Stored Platelets for the Treatment of Surgical Bleeding: The CLIP-II Randomized Noninferiority Clinical Trial Michael C. Reade, Denese C. Marks, Belinda D. Howe, et al JAMA Published Online: December 8, 2025 doi: 10.1001/jama.2025.23355 Key Points Question  Are cryopreserved platelets less effective and safe than conventional liquid-stored platelets in...

Article Published: 28 September 2024 Effectiveness of influenza vaccines in preventing acute cardiovascular events within 1 year in Beijing, China Yuan Ma, Feng Lu, Luodan Suo, et al npj Vaccines 9, 177 (2024) https://doi.org/10.1038/s41541-024-00969-y Abstract Controversies persist about the protective effects of vaccines against acute cardiovascular events. Using electronic medical records from hospitals and influenza vaccine administration d...