Original Investigation  Oncology March 27, 2025 Late-Onset Immune-Related Adverse Events After Immune Checkpoint Inhibitor Therapy Sienna M. Durbin, Leyre Zubiri, Katherine Perlman, et al JAMA Netw Open. 2025;8(3):e252668. doi:10.1001/jamanetworkopen.2025.2668 Key Points Question  What is the frequency of late-onset immune-related adverse events (irAEs) among patients treated with immune chec...

Original Investigation  March 26, 2025 Long-Term Risk of Stroke After Transient Ischemic Attack or Minor Stroke: A Systematic Review and Meta-Analysis Writing Committee for the PERSIST Collaborators JAMA. Published online March 26, 2025. doi:10.1001/jama.2025.2033 Key Points Question  What is the long-term risk of stroke after transient ischemic attack (TIA) or minor stroke? Findings  In this systematic review a...

Original Investigation  Caring for the Critically Ill Patient April 14, 2025 Use of Life Support and Outcomes Among Patients Admitted to Intensive Care Units Emily E. Moin, Nicholas J. Seewald, Scott D. Halpern JAMA. Published online April 14, 2025. doi:10.1001/jama.2025.2163 Key Points Question  How have intensive care unit (ICU) care and outcomes changed in the United States over the past decade? Findings  In th...

Original Investigation  March 26, 2025 Perioperative Penicillin and Cephalosporin Antibiotic Allergy Assessment and Testing: The PREPARE Pilot Randomized Clinical Trial Joseph Francis De Luca, Sara Vogrin, Natasha Elizabeth Holmes, et al JAMA Surg. Published online March 26, 2025. doi:10.1001/jamasurg.2025.0279 Key Points Question  Can penicillin and cephalosporin allergy delabeling be performed...

Original Investigation  Critical Care Medicine May 19, 2025 Cost-Effectiveness of α2 Agonists for Intravenous Sedation in Patients With Critical Illness Stephen Morris, Nazir I. Lone, Cathrine A. McKenzie, et al JAMA Netw Open. 2025;8(5):e2517533. doi:10.1001/jamanetworkopen.2025.17533 Key Points Question  What is the cost-effectiveness of dexmedetomidine, clonidine, and propofol for intravenous sedation in patients with ...

Original Investigation  Critical Care Medicine March 25, 2025 Recovery Potential in Patients After Cardiac Arrest Who Die After Limitations or Withdrawal of Life Support Jonathan Elmer, Patrick J. Coppler, Cecelia Ratay, et al JAMA Netw Open. 2025;8(3):e251714. doi:10.1001/jamanetworkopen.2025.1714 Key Points Question  How often do experts believe that there was recovery potential in patients who had limitations or withdrawal ...

Research Care guided by tissue oxygenation and haemodynamic monitoring in off-pump coronary artery bypass grafting (Bottomline-CS): assessor blind, single centre, randomised controlled trial Jiange Han, Wenqian Zhai, Zhenhua Wu, et al BMJ 2025; 388 doi: https://doi.org/10.1136/bmj-2024-082104 (Published 24 March 2025) Cite this as: BMJ 2025;388:e082104 Abstract Objective To assess whether perioperative management guided by near-infrared spectroscopy to d...

Original Investigation  Caring for the Critically Ill Patient May 19, 2025 Dexmedetomidine- or Clonidine-Based Sedation Compared With Propofol in Critically Ill Patients: The A2B Randomized Clinical Trial Timothy S. Walsh, Richard A. Parker, Leanne M. Aitken, et al JAMA. Published online May 19, 2025. doi:10.1001/jama.2025.7200 Key Points Question  Does primary sedation with dexmedetomidine or clonidine (α2-adrenergic receptor...

JAMA Data Brief  AI in Medicine March 21, 2025 Poll: Trust in AI for Accurate Health Information Is Low Avery Orrall; Andy Rekito JAMA. Published online March 21, 2025. doi:10.1001/jama.2024.22951 JAMA Medical News As more artificial intelligence (AI) tools become available online, people are struggling to differentiate truth from fiction, including when it comes to health information. As part of its ongoing survey o...

Original Investigation  Infectious Diseases March 20, 2025 Midline Venous Catheter vs Peripherally Inserted Central Catheter for Intravenous Therapy: A Randomized Clinical Trial Ahmed Bentridi, Marie-France Giroux, Gilles Soulez, et al JAMA Netw Open. 2025;8(3):e251258. doi:10.1001/jamanetworkopen.2025.1258 Key Points Question  Is a midline venous catheter (MVC) a noninferior alternative to a...