Melatonin for prevention of delirium in patients receiving mechanical ventilation in the intensive care unit: a multiarm multistage adaptive randomized controlled clinical trial (DEMEL) Mekontso Dessap, A., Ricard, JD., Contou, D. et al. Intensive Care Med(2025). https://doi.org/10.1007/s00134-025-08002-z Abstract Purpose To determine the dose of melatonin with an optimal pharmacokinetic profile and to test whether this dose reduces the prevalence of deliri...

Combined use of a multiplex PCR and serum procalcitonin to reduce antibiotic exposure in critically ill patients with community-acquired pneumonia: the MULTI-CAP randomized controlled trial Voiriot, G., Argaud, L., Cohen, Y. et al. Intensive Care Med(2025). https://doi.org/10.1007/s00134-025-08014-9 Abstract Purpose Multiplex polymerase chain reaction (mPCR) testing has the potential to rapidly and accurately identify causative microorganisms in patients wi...

Early versus delayed catheter drainage for patients with necrotizing pancreatitis and early persistent organ failure (TIMING): a multicenter randomized controlled trial Ke, L., Li, G., Mao, W. et al. Intensive Care Med (2025). https://doi.org/10.1007/s00134-025-08020-x Abstract Purpose Acute necrotic collection (ANC) is an early, local complication of necrotizing pancreatitis, and guidelines recommend a deliberate delay in treating ANC. In patients with ear...

ONLINE FIRST (FREE ACCESS) STANDARD OF CARE IN THE INTENSIVE CARE UNIT OPEN ACCESS ~ What's New in Intensive Care Renal replacement therapyGaudry S., Srisawat N. & Joannidis M. LATEST ARTICLES Original Short- and long-term outcomes and 15-year time trends of kidney replacement therapy in critically ill patients with obesity: an observational cohortMonet C., Bouziane J., Pensier J., et al. Altered lower brainstem neurophysiological response is asso...

Original Investigation  Health Informatics Electronic Health Record Interventions to Reduce Risk of Hospital Readmissions: A Systematic Review and Meta-Analysis Badal S. B. Pattar, Abigail Ackroyd, Emir Sevinc, et al JAMA Netw Open 2025;8;(7):e2521785. doi:10.1001/jamanetworkopen.2025.21785 Key Points Question  Are electronic health record (EHR)–based interventions associated with reduced risk of hospital...

Research Letter  Initial Antibiotic Selection Strategy and Subsequent Antibiotic Use—Insights From the INSPIRE Trials Shruti K. Gohil, Edward Septimus, Ken Kleinman, et al JAMA Published Online: July 17, 2025 doi: 10.1001/jama.2025.11256 Four cluster-randomized trials have demonstrated that a stewardship bundle including real-time computerized provider order entry (CPOE) prompts safely reduced initial extend...

Critical Care: Research Letters Use of High-Dose Hydroxocobalamin for Septic Shock Jason R. Carr, Brian Locke, Jayshil J. Patel, et al Chest 2025; 168: 131-135 To the Editor: Septic shock, a global health burden with a case fatality rate exceeding 40%, is initiated and maintained by circulating nitric oxide and hydrogen sulfide that are emergent targets of therapeutic interest.1 High-dose (5-gm) hydroxocobalamin (vitamin B12) (HD-HOC) scavenges circula...

Original Investigation  Infectious Diseases Estimated Burden of Influenza and Direct and Indirect Benefits of Influenza Vaccination Mary G. Krauland, Alexis Mandell, Mark S. Roberts JAMA Netw Open 2025;8;(7):e2521324. doi:10.1001/jamanetworkopen.2025.21324 Key Points Question  What is the estimated influenza case burden, both direct and indirect, averted by vaccination? Findings  This decision ana...

Research Letter  Oncology “Me-Too” Drugs Compared With Original Drugs in Randomized Clinical Trials Timothée Olivier, Calvin Smith, Vinay Prasad, et al JAMA Intern Med Published Online: July 14, 2025 doi: 10.1001/jamainternmed.2025.2892 The development of “me-too” or “next-in-class” drugs in oncology may offer benefits including improved efficacy, better safety profiles, or economic competition.1,2 Addi...

Original Investigation  Public Health Body Mass Index in Children Before, During, and After the COVID-19 Pandemic Frederik Kirkemann Jensen, Sigrid Bjerge Gribsholt, Sara Schwartz, et al JAMA Netw Open 2025;8;(7):e2519528. doi:10.1001/jamanetworkopen.2025.19528 Key Points Question  Did prevalence of underweight, overweight, and obesity in schoolchildren change during and after the COVID-19 pandemic compared wi...