Baseline characteristics of patients in the Chinese Bronchiectasis Registry (BE-China): a multicentre prospective cohort study Jin-Fu Xu, Hui-Zhen Zheng, Hai-Wen Lu, et al Lancet Respir Med Available online 10 January 2025 https://doi.org/10.1016/S2213-2600(24)00364-3 Summary Background Bronchiectasis is a disease with a global impact, but most published data come from high-income countries. We aimed to describe the clinical characteristics of patients w...

Associations between childhood trauma and adolescent psychiatric disorders in Brazil: a longitudinal, population-based birth cohort study Megan Bailey, Graeme Fairchild, Gemma Hammerton, et al Lancet Global Health 2025; 13: e309-e318 https://doi.org/10.1016/S2214-109X(24)00452-2 Summary Background The mental health consequences of exposure to childhood trauma have been little studied among adolescents in low-income and-middle-income countries (LMICs), de...

Evaluating culture-free targeted next-generation sequencing for diagnosing drug-resistant tuberculosis: a multicentre clinical study of two end-to-end commercial workflows Rebecca E Colman, Marva Seifert, Andres De la Rossa, et al Lancet Infect Dis Available online 29 October 2024 https://doi.org/10.1016/S1473-3099(24)00586-3 Summary Background Drug-resistant tuberculosis remains a major obstacle in ending the global tuberculosis epidemic. Deployment of ...

The prevalence of hypoxaemia in paediatric and adult patients in health-care facilities in low-income and middle-income countries: a systematic review and meta-analysis Hamish R Graham, Esrat Jahan, Rami Subhi, et al Lancet Global Health 2025; 13: e222-e231 https://doi.org/10.1016/S2214-109X(24)00469-8 Summary Background Hypoxaemia (low oxygen saturation in blood) is a key predictor of in-hospital mortality, affecting people of all ages with many differe...

Effectiveness of 2023 southern hemisphere influenza vaccines against severe influenza-associated illness: pooled estimates from eight countries using the test-negative design Radhika Gharpure, Annette K Regan, Francisco Nogareda, et al Lancet Global Health 2025; 13: e203-e211 https://doi.org/10.1016/S2214-109X(24)00473-X Summary Background Annual estimates of seasonal influenza vaccine effectiveness can guide global risk communication and vaccination str...

Prevalence, aetiology, and hospital outcomes of paediatric acute critical illness in resource-constrained settings (Global PARITY): a multicentre, international, point prevalence and prospective cohort study Teresa B Kortz, Adrian Holloway, Asya Agulnik, et al Lancet Global Health 2025; 13: e212-e221 https://doi.org/10.1016/S2214-109X(24)00450-9 Summary Background Children in resource-constrained settings (RCS) have disproportionately high illness and mo...

Safety and efficacy of nipocalimab in adults with generalised myasthenia gravis (Vivacity-MG3): a phase 3, randomised, double-blind, placebo-controlled study Carlo Antozzi, Tuan Vu, Sindhu Ramchandren, et al Lancet Neurol 2025; 24: 105-116 https://doi.org/10.1016/S1474-4422(24)00498-8 Summary Background Given burdensome side-effects and long latency for efficacy with conventional agents, there is a continued need for generalised myasthenia gravis treatme...

Effectiveness of ceftazidime–avibactam versus ceftolozane–tazobactam for multidrug-resistant Pseudomonas aeruginosainfections in the USA (CACTUS): a multicentre, retrospective, observational study Ryan K Shields, Lilian M Abbo, Renee Ackley, et al Lancet Infect Dis Available online 16 December 2024 https://doi.org/10.1016/S1473-3099(24)00648-0 Summary Background Ceftolozane–tazobactam and ceftazidime–avibactam are preferred treatment options for multidru...

Global, regional, and national age-sex-specific burden of diarrhoeal diseases, their risk factors, and aetiologies, 1990–2021, for 204 countries and territories: a systematic analysis for the Global Burden of Disease Study 2021 GBD 2021 Diarrhoeal Diseases Collaborators Lancet Infectious Diseases Available online 18 December 2024 https://doi.org/10.1016/S1473-3099(24)00691-1 Summary Background Diarrhoeal diseases claim more than 1 million lives annually and...

Robust Meta-Model for Predicting the Likelihood of Receiving Blood Transfusion in Non-traumatic Intensive Care Unit Patients ALIREZA RAFIEI , RONALD MOORE, TILENDRA CHOUDHARY, et al HEALTH DATA SCIENCE 2024; 4: 0197 DOI: 10.34133/hds.0197 Abstract Background: Blood transfusions, crucial in managing anemia and coagulopathy in intensive care unit (ICU) settings, require accurate prediction for effective resource allocation and patient risk assessment. However...