ARTICLE March 22, 2026 Procalcitonin testing combined with NEWS2 evaluation compared with usual care based on NEWS2 for identification of sepsis and antibiotic initiation in the emergency department in England and Wales (PRONTO): a multicentre, randomised, controlled, open-label, phase 3 trial Stacy Todd, Joanne Euden, Jennifer Condie, et al Lancet Respir Med Published March 22, 2026 DOI: 10.1016/S2213-2600(25)00433-3 Summary Background Sepsis is a co...

Original Investigation  Caring for the Critically Ill Patient National Estimates of Pediatric Sepsis in US Hospitals Using Clinical Data Chanu Rhee, Fran Balamuth, Kevin Dysart, et al JAMA Published Online: March 22, 2026 doi: 10.1001/jama.2026.3100 Key Points Question  What is the burden of nonneonatal pediatric sepsis in US hospitals using an electronic health record–based surveillance defi...

ARTICLES March 21, 2026Open Access Endotracheal surfactant for infants with life-threatening bronchiolitis (BESS): a randomised, blinded, sham-controlled, phase 2 trial Malcolm G Semple, Chloe Donohue, Laura Price, et al Lancet Respir Med Published March 21, 2026 DOI: 10.1016/S2213-2600(26)00008-1 Summary Background Bronchiolitis is a common viral respiratory disease of infants, with severity ranging from mild symptoms, such as coryza and feeding diff...

LATEST ARTICLES Original Sex, time, and disability status differences in mortality, multidimensional morbidity, and health care utilization: a secondary analysis of the Canadian RECOVER study Burns, K.E.A., Huszti, E., Li, Q. et al. Temporary mechanical support in fulminant myocarditis: prognostic factors and clinical implications from the FULLMOON study Schmidt, M., Ponnaiah, M., Huang, F. et al. Spontaneous breathing trials as predictors of extubation ...

JOURNAL ARTICLE Aspergillosis-Attributable Mortality in the United States: Analysis of Death Certificate Data Thomas J Walsh, Dakota Sicignano, Matthew Mastropietro, et al Clinical Infectious Diseases, Volume 82, Issue 1, 15 January 2026, Pages 86–92, https://doi.org/10.1093/cid/ciaf653 Abstract Background The nationwide attributable mortality of aspergillosis in the era of mold-active triazoles is poorly understood. Methods We ...

Original Investigation  Infectious Diseases Incidence and Outcomes of Candida Bloodstream Infection in Solid Organ Transplant Recipients Roni Bitterman, Julianne V. Kus, Geena Verma, et al JAMA Netw Open 2026;9;(3):e261467. doi:10.1001/jamanetworkopen.2026.1467 Key Points Question  What are the incidence and outcomes of candidemia in solid organ transplant recipients (SOTRs)? Findings &n...

Original Investigation  Critical Care Medicine Incidence of Adverse Events in Peripheral Intravenous Vasopressor Use: A Systematic Review and Meta-Analysis Shang-Jun ZhangJian, Kuang-Yu Niu, Chen-Bin Chen, et al JAMA Netw Open 2026;9;(3):e260710. doi:10.1001/jamanetworkopen.2026.0710 Key Points Question  What is the incidence of adverse events (AEs) and avoidance of central venous catheter (CVC) placement...

Articles Global policy responses to antimicrobial resistance, 2021–22: a systematic governance analysis of 161 countries and territories Jay Patel, Sahar Saeedi Moghaddam, Sruthi Ranganathan, et al Lancet Infect Dis 2026; 26: 55-66 https://doi.org/10.1016/S1473-3099(25)00406-2 Summary Background Most countries have endorsed a national action plan (NAP) on antimicrobial resistance. We previously used a governance framework to assess NAPs on antimicrobi...

Original Investigation  Obstetrics and Gynecology Pregnancy- and Abortion-Related Mortality in the US, 2018-2021 Maria W. Steenland, Kerra Mercon, Benjamin P. Brown, et al JAMA Netw Open 2026;9;(1):e2554793. doi:10.1001/jamanetworkopen.2025.54793 Key Points Question  What is the ratio between pregnancy-related and abortion-related mortality? Findings  This cross-sectional study using national...

CORRESPONDENCE PUBLIC HEALTH ALERTS Andes Hantavirus Outbreak on a Cruise Ship, 2026 Andes Virus Outbreak Working Group N Engl J Med Published May 20, 2026 DOI: 10.1056/NEJMc2606496 TO THE EDITOR: On April 27, 2026, a man (later classified as Patient 3 in the outbreak) was medically evacuated to Ascension Island from the Dutch-flagged expedition cruise ship MV Hondius; he had severe acute respiratory infection (SARI) and reported shortness of bre...