Original Investigation  Health Informatics Large Language Model Performance and Clinical Reasoning Tasks Arya S. Rao, Kaiz P. Esmail, Richard S. Lee, et al JAMA Netw Open 2026;9;(4):e264003. doi:10.1001/jamanetworkopen.2026.4003 Key Points Question  Can off-the-shelf large language models (LLMs) demonstrate reliable performance across the clinical workflow? Findings  In this cross-sectional s...

Original Investigation  Pediatrics Changes in Academic Standardized Testing After Pediatric Intensive Care Claire C. Foster, Melanie Boyd, Erin F. Carlton, et al JAMA Netw Open 2026;9;(4):e269948. doi:10.1001/jamanetworkopen.2026.9948 Key Points Question  Is pediatric intensive care unit (PICU) admission associated with a decrease in academic achievement assessment scores? Findings  In this c...

ONLINE FIRST (FREE ACCESS) LATEST ARTICLES Original Prophylactic noninvasive ventilation after extubation in high-risk patients without hypercapniaThille, A.W., Chamblet, L., Ragot, S. et al. OPEN ACCESS ~ Imaging in Intensive Care Medicine Demonstration of the acute hemodynamic effects of dynamic left ventricular outflow obstructionYao, R.J.R., Jiang, M., Lee, R. et al. OPEN ACCESS ~ Narrative Review Mechanical ventilation for ICU patient w...

Articles Global, regional, and national burden of meningitis, its risk factors, and aetiologies, 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023 GBD 2023 Meningitis & Antimicrobial Resistance Collaborators Summary Background Meningitis remains the leading infectious cause of neurological disabilities globally, disproportionately affecting children younger than 5 years and populations in the African meningitis belt. Whereas p...

Articles Efficacy and safety of cemdisiran siRNA in myasthenia gravis (NIMBLE): a double-blind, randomised, placebo-controlled, phase 3 trial Tuan Vu, Ali A Habib, Saiju Jacob, et al Lancet 2026; 407: 1712-1725 https://doi.org/10.1016/S0140-6736(26)00690-2 Summary Background Autoantibody-mediated complement activation drives pathology in acetylcholine receptor (AChR) antibody-positive generalised myasthenia gravis. Newer targeted therapies lower overa...

Original Investigation  MySurgeryRisk Model Predictions of Postoperative Complications and Mortality Yuanfang Ren, Esra Adiyeke, Ziyuan Guan, et al JAMA Surg Published Online: April 29, 2026 doi: 10.1001/jamasurg.2026.1112 Key Points Question  Will applying the MySurgeryRisk framework, originally developed and prospectively validated on a single-center dataset, to a large multicenter dataset enh...

Original Investigation  Emergency Medicine Out-of-Hospital Cardiac Arrest Survival at Nighttime: A Nationwide Cohort Study Joshua M. Kimbrell, Tanner Smida, Judah A. Kreinbrook, et al JAMA Netw Open 2026;9;(4):e269828. doi:10.1001/jamanetworkopen.2026.9828 Key Points Question  Does out-of-hospital cardiac arrest resuscitation with nighttime prehospital response remain associated with low rates of survival u...

ORIGINAL ARTICLE Health Care–Associated Infections in U.S. Hospitals, 2023 versus 2015 Nora Chea, Rongxia Li, Taniece Eure, et al N Engl J Med 2026;395:255-266 DOI: 10.1056/NEJMoa2510881 Abstract BACKGROUND Prevalence surveys in U.S. hospitals showed that on any given day, 1 of 25 patients had a health care–associated infection in 2011, as compared with 1 of 31 patients in 2015. We repeated the survey in 2023 to assess changes in the prevalence of suc...

Articles Bedside identification of subphenotypes in acute respiratory failure (PHIND): a multicentre, observational cohort study Kiran Reddy, Pratik Sinha, David B Antcliffe, et al Lancent Respir Med Available online 23 March 2026 https://doi.org/10.1016/S2213-2600(26)00040-8 Summary Background Acute respiratory distress syndrome (ARDS) is a clinically defined, biologically heterogeneous condition with no proven disease-modifying therapies. Retrospect...

Articles Polymyxin B haemoadsorption in endotoxic septic shock (Tigris): a multicentre, open-label, Bayesian, randomised, controlled, phase 3 trial Javier A Neyra, Matthieu Legrand, Mark A Tidswell, et al Lancet Respir Med Available online 23 March 2026 https://doi.org/10.1016/S2213-2600(26)00047-0 Summary Background Endotoxic septic shock, a subset of septic shock with high endotoxin activity and multiorgan failure, is associated with high risk of de...