Articles Trends in mortality due to haemophagocytic lymphohistiocytosis across 29 European countries from 2011 to 2021: a retrospective, international, population-based study Leher Gumber, Reza Omidvar, Francesca Gonnelli, et al Lancet Rheumatol 2026; 8: e108-e115 https://doi.org/10.1016/S2665-9913(25)00292-9 Summary Background Previous research has suggested that the incidence of haemophagocytic lymphohistiocytosis is increasing in Europe. We aimed t...

Articles Global burden of lower respiratory infections and aetiologies, 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023 GBD 2023 Lower Respiratory Infections and Antimicrobial Resistance Collaborators Lancet Infect Dis Available online 15 December 2025 https://doi.org/10.1016/S1473-3099(25)00689-9 Summary Background Lower respiratory infections (LRIs) remain the world's leading infectious cause of death. This analysis from...

Articles Cefiderocol versus standard therapy for hospital-acquired and health-care-associated Gram-negative bacterial bloodstream infection (the GAME CHANGER trial): an open-label, parallel-group, randomised trial David L Paterson, Helmi Sulaiman, Po-Yu Liu, et al Lancet Infect Dis 2026; 26: 148-159 https://doi.org/10.1016/S1473-3099(25)00469-4 Summary Background Bloodstream infections caused by bacteria with carbapenem resistance are associated with ...

Articles Efficacy and safety of minocycline in patients with acute ischaemic stroke (EMPHASIS): a multicentre, double-blind, randomised controlled trial Yao Lu, Ling Guan, Jialing Wu, et al Lancet Available online 30 January 2026 https://doi.org/10.1016/S0140-6736(25)01862-8 Summary Background Minocycline has been reported as a multi-target anti-neuroinflammatory drug with potential benefits for ischaemic stroke in preclinical models and small-scale c...

ONLINE FIRST (FREE ACCESS) LATEST ARTICLES Original Sex, time, and disability status differences in mortality, multidimensional morbidity, and health care utilization: a secondary analysis of the Canadian RECOVER studyBurns, K.E.A., Huszti, E., Li, Q. et al. EditorialUpdate on infection: from prevention to diagnosis and managementNseir, S., Salluh, J.I.F. & Póvoa, P. Update on sepsis and septic shock: from bundles to precision medicinePlata-Menchaca, E....

Research Letter  AI in Medicine Self-Disclosed Use of AI in Research Submissions to BMJ Journals Isamme AlFayyad, Maurice P. Zeegers, Lex Bouter, et al JAMA Published Online: January 28, 2026 doi: 10.1001/jama.2025.25688 Artificial intelligence (AI), including generative AI, has rapidly emerged as a powerful tool in scientific research and publication.1 Current estimates of AI use rely on self-reported su...

Research Letter  AI in Medicine Author Disclosure of Use of AI in Submissions to 13 JAMA Network Journals Roy H. Perlis, Annette Flanagin, Jacob Kendall-Taylor, et al JAMA Published Online: January 28, 2026 doi: 10.1001/jama.2025.25300 The scientific community has not reached consensus about the appropriate application of artificial intelligence (AI) in manuscript preparation and review.1 In August 2023, JAMA ...

Original Investigation  US State-Level Prevalence of Adult Obesity by Race and Ethnicity From 1990 to 2022 and Forecasted to 2035 Nicole K. DeCleene, Ethan Kahn, Chun-Wei Yuan, et al JAMA Published Online: January 28, 2026 doi: 10.1001/jama.2025.26817 Key Points Question  What are the current and future estimates of obesity prevalence in the US by state, race and ethnicity group, sex, and age? ...

ONLINE FIRST (FREE ACCESS) LATEST ARTICLES Original Dynamic driving pressure and clinical outcomes in mechanically ventilated patients with acute brain injury: a secondary analysis of the VENTIBRAIN studyTaran, S., Citerio, G., Taccone, F.S. et al. What's New in Intensive CareVascular permeability and loss of glycocalix in sepsis: the role of fluid resuscitationJuffermans, N.P., Radermacher, P. & Joffre, J. ICU toolbox: negotiation skills for family con...

Original Investigation  Transcutaneous Electrical Acupoint Stimulation vs Metoclopramide for Moderate to Severe Postoperative Nausea and Vomiting: A Randomized Clinical Trial Dong-yu Zheng, Peng Ding, Ming Gong, et al JAMA Surg Published Online: January 28, 2026 doi: 10.1001/jamasurg.2025.6394 Key Points Question  Is wearable transcutaneous electrical acupoint stimulation effective in managing m...