Research Letter  Emergency Medicine Electric Fan Use With Dehydration in Extreme Heat and Humidity: A Randomized Crossover Trial Connor Graham, Lily Hospers, Ollie Jay JAMA Netw Open 2025;8;(8):e2526701. doi:10.1001/jamanetworkopen.2025.26701 Introduction Heat extremes have devastating impacts on human health. More than 60 000 heat-related deaths occurred in the 2022 European summer,1 while record-breaking temperat...

Original Investigation  Dalbavancin for Treatment of Staphylococcus aureus Bacteremia: The DOTS Randomized Clinical Trial Nicholas A. Turner, Toshimitsu Hamasaki, Sarah B. Doernberg, et al JAMA Published Online: August 13, 2025 doi: 10.1001/jama.2025.12543 Key Points Question  Is dalbavancin a superior treatment option for complicated Staphylococcus aureus bacteremia compared...

Research Letter  Characterization of Research Grant Terminations at the National Institutes of Health Michael Liu, Kushal T. Kadakia, Vishal R. Patel, et al JAMA 2025;334;(6):534-536. doi:10.1001/jama.2025.7707 The National Institutes of Health (NIH) recently initiated a series of grant terminations focused on topics not aligned with agency priorities.1 The scope of terminations, types of grants affected, and differ...

Research Sex related differences in efficacy and safety of antithrombotic therapy in patients with coronary artery disease: systematic review and meta-analysis Raffaele Piccolo, Angelo Laino, Antonio Pio Vitale, et al BMJ 2025; 390 doi: https://doi.org/10.1136/bmj-2024-082974 (Published 29 July 2025)Cite this as: BMJ 2025;390:e082974 Abstract Objective To evaluate sex related differences in the treatment effect of antithrombotic therapy in patients wit...

Original Investigation  Infectious Diseases Antibiotic Use and the Risk of Hospital-Onset Clostridioides Difficile Infection Mayan Gilboa, Gili Regev-Yochay, Eyal Meltzer, et al JAMA Netw Open Published Online: August 8, 2025 2025;8;(8):e2525252. doi:10.1001/jamanetworkopen.2025.25252 Key Points Question  What is the hazard of Clostridioides difficile infection (CDI) between asymptomatic carriers compared with noncar...

Articles Global, regional, and national prevalence of kidney failure with replacement therapy and associated aetiologies, 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023 GBD 2023 Kidney Failure with Replacement Therapy Collaborators Lancet Global Health 2025; 13: e1378-e1395 Summary Background Kidney failure with replacement therapy (KFRT) such as dialysis or transplantation represents a severe stage of chronic kidney disease...

Articles Rates of infection with other pathogens after a positive COVID-19 test versus a negative test in US veterans (November, 2021, to December, 2023): a retrospective cohort study Miao Cai, Evan Xu, Yan Xie, et al Lancet Infect Dis 2025; 25: 847-860 Summary Background SARS-CoV-2 infection leads to post-acute sequelae that can affect nearly every organ system, including the immune system. However, whether an infection with SARS-CoV-2 is associated wit...

The burden of β-lactam allergy labels in health care: a systematic review and meta-analysis Mengyuan Fu, Lin Hu, Kexin Han, et al Lancet Infect Dis 2025; 25: 896-908 Summary Background Unverified β-lactam allergy labels (BALs) pose a considerable barrier to optimal antimicrobial treatment and represent a growing public health concern. However, no comprehensive meta-analysis has been conducted to explore the associations between BALs and clinical outcomes. W...

Efficacy and safety of individualised versus standard 10-day antibiotic treatment in children with febrile urinary tract infection (INDI-UTI): a pragmatic, open-label, multicentre, randomised, controlled, non-inferiority trial in Denmark Naqash Javaid Sethi, Emma Louise Malchau Carlsen, Abdullah Tabassum, et al Lancet Infect Dis 2025; 25: 925-935 Summary Background The optimal antibiotic duration for febrile urinary tract infection (UTI) in children remains...

Research Letter  Climate Change and Health Excess Deaths Attributable to the Los Angeles Wildfires From January 5 to February 1, 2025 Eugenio Paglino, Rafeya V. Raquib, Andrew C. Stokes JAMA Published Online: August 6, 2025 doi: 10.1001/jama.2025.10556 In January 2025, 2 major wildfires impacted Los Angeles County, California. Officials reported 30 direct fatalities,1but additional health impacts are likely.2 ...