ARTICLES|ONLINE FIRST Arginine-stimulated copeptin measurements in the differential diagnosis of diabetes insipidus: a prospective diagnostic study Bettina Winzeler, Nicole Cesana-Nigro, Julie Refardt, et al Lancet Published: July 11, 2019 DOI:https://doi.org/10.1016/S0140-6736(19)31255-3 Summary Background 背景 Differential diagnosis of diabetes insipidus is challenging. The most reliable approach is hypertonic saline-stimulated copeptin measurements. H...

Research Association of changes in red meat consumption with total and cause specific mortality among US women and men: two prospective cohort studies Yan Zheng, Yanping Li, Ambika Satija, et al BMJ 2019; 365: l2110 doi:https://doi.org/10.1136/bmj.l2110 Abstract Objective 目的 To evaluate the association of changes in red meat consumption with total and cause specific mortality in women and men. 评价红肉摄入的改变对女性和男性全因死亡率与疾病特异性死亡...

Pessimism in providing critical care for elderly patients A recent study conducted in France investigated the association of age with long-term mortality after discharge from the ICU. Another subset of this discussion relates to the critically ill elderly patients who have higher mortality compared to younger patients as well as longer lengths of stay in the ICU prior to death.  There has been a great deal of discussion on how a disproportionate amount of health...

ORIGINAL ARTICLE C-Reactive Protein Testing to Guide Antibiotic Prescribing for COPD Exacerbations Christopher C. Butler, David Gillespie, Patrick White, et al N Engl J Med 2019; 381:111-120DOI: 10.1056/NEJMoa1803185 Abstract BACKGROUND 背景 Point-of-care testing of C-reactive protein (CRP) may be a way to reduce unnecessary use of antibiotics without harming patients who have acute exacerbations of chronic obstructive pulmonary disease (COPD). ...

ARTICLES|ONLINE FIRST Causes of severe pneumonia requiring hospital admission in children without HIV infection from Africa and Asia: the PERCH multi-country case-control study The Pneumonia Etiology Research for Child Health (PERCH) Study Group Lancet Published: June 27, 2019 DOI:https://doi.org/10.1016/S0140-6736(19)30721-4 Summary Background 背景 Pneumonia is the leading cause of death among children younger than 5 years. In this study, we estimated c...

ARTICLES|ONLINE FIRST The burden of Legionnaires' disease in New Zealand (LegiNZ): a national surveillance study Patricia C Priest, Sandy Slow, Stephen T Chambers, et al Lancet Published:June 10, 2019 DOI:https://doi.org/10.1016/S1473-3099(19)30113-6 Summary Background 背景 Legionnaires' disease is under-diagnosed because of inconsistent use of diagnostic tests and uncertainty about whom to test. We assessed the increase in case detection following large...

ARTICLES| VOLUME 19, ISSUE 6, P601-610, JUNE 01, 2019 Effect of carbapenem resistance on outcomes of bloodstream infection caused by Enterobacteriaceae in low-income and middle-income countries (PANORAMA): a multinational prospective cohort study Andrew J Stewardson, Kalisvar Marimuthu, Sharmila Sengupta, et al Lancet Infect Dis 2019; 19: 601-610 Summary Background 背景 Low-income and middle-income countries (LMICs) are under-represented i...

ONLINE FIRST THIS WEEK(FREE ACCESS) Review ~ Assoun S. - Molecular targeted therapy-related life-threatening toxicity in patients with malignancies. A systematic review of published cases Original ~ Haines K. J. - Key mechanisms by which post-ICU activities can improve in-ICU care: results of the international THRIVE collaboratives Imaging in Intensive Care Medicine ~ Salden R. L. T. N. - Camel shape in transpulmonary thermodilution monitoringWhat's new in intensive ca...

ARTICLES|ONLINE FIRST Association between urinary dickkopf-3, acute kidney injury, and subsequent loss of kidney function in patients undergoing cardiac surgery: an observational cohort study Stefan J Schunk, Alexander Zarbock, Melanie Meersch, et al Lancet Published:June 12, 2019 DOI:https://doi.org/10.1016/S0140-6736(19)30769-X Summary Background 背景 Cardiac surgery is associated with a high risk of postoperative acute kidney injury (AKI) and sub...

ARTICLES|ONLINE FIRST Chlorhexidine for meatal cleaning in reducing catheter-associated urinary tract infections: a multicentre stepped-wedge randomised controlled trial Oyebola Fasugba, Prof Allen C Cheng, Victoria Gregory, et al Lancet Infect Dis Published: April 12, 2019 DOI: https://doi.org/10.1016/S1473-3099(18)30736-9 Summary Background 背景 Evidence for the benefits of antiseptic meatal cleaning in reducing catheter-associated urinary tract i...