ORIGINAL ARTICLE Bag-Mask Ventilation during Tracheal Intubation of Critically Ill Adults Jonathan D. Casey, David R. Janz, Derek W. Russell, et al  N Engl J Med February 18, 2019DOI: 10.1056/NEJMoa1812405 BACKGROUND 背景 Hypoxemia is the most common complication during tracheal intubation of critically ill adults and may increase the risk of cardiac arrest and death. Whether positive-pressure ventilation with a bag-mask device (bag-mask ventilation) during...

ORIGINAL ARTICLE Adjunctive Intermittent Pneumatic Compression for Venous Thromboprophylaxis Yaseen M. Arabi, Fahad Al-Hameed, Karen E.A. Burns, et al N Engl J Med February 18, 2019DOI: 10.1056/NEJMoa1816150 BACKGROUND 背景 Whether adjunctive intermittent pneumatic compression in critically ill patients receiving pharmacologic thromboprophylaxis would result in a lower incidence of deep-vein thrombosis than pharmacologic thromboprophylaxis alone is uncertai...

Original Investigation February 18, 2019 Effect of Titrating Positive End-Expiratory Pressure (PEEP) With an Esophageal Pressure–Guided Strategy vs an Empirical High PEEP-Fio2 Strategy on Death and Days Free From Mechanical Ventilation Among Patients With Acute Respiratory Distress Syndrome: A Randomized Clinical Trial Jeremy R. Beitler, Todd Sarge, Valerie M. Banner-Goodspeed, et al; for the EPVent-2 Study Group JAMA. Published online February 18, 2019. doi:10.1...

Original Investigation Effect of a Resuscitation Strategy Targeting Peripheral Perfusion Status vs Serum Lactate Levels on 28-Day Mortality Among Patients With Septic Shock： The ANDROMEDA-SHOCK Randomized Clinical Trial Glenn Hernández, Gustavo A. Ospina-Tascón, Lucas Petri Damiani, et al JAMA. Published online February 17, 2019. doi:10.1001/jama.2019.0071 Abstract Importance  背景 Abnormal peripheral perfusion after septic shock resuscitation has been ...

Long-term developmental effects of withholding parenteral nutrition for 1 week in the paediatric intensive care unit: a 2-year follow-up of the PEPaNIC international, randomised, controlled trial Sören Verstraete, Sascha C Verbruggen, José A Hordijk, et al Lancet Respir Med 2019; 7: 141-153 Background 背景 The paediatric early versus late parenteral nutrition in critical illness (PEPaNIC) multicentre, randomised, controlled trial showed that, compared wit...