Intensive blood pressure reduction with intravenous thrombolysis therapy for acute ischaemic stroke (ENCHANTED): an international, randomised, open-label, blinded-endpoint, phase 3 trial Craig S Anderson, Yining Huang, Richard I Lindley, et al Lancet Published:February 07, 2019 DOI:https://doi.org/10.1016/S0140-6736(19)30038-8 Summary Background 背景 Systolic blood pressure of more than 185 mm Hg is a contraindication to thrombolytic treatment with intraven...

Efficacy and safety of minimally invasive surgery with thrombolysis in intracerebral haemorrhage evacuation (MISTIE III): a randomised, controlled, open-label, blinded endpoint phase 3 trial Daniel F Hanley, Richard E Thompson, Michael Rosenblum, et al Lancet Published:February 07, 2019 DOI:https://doi.org/10.1016/S0140-6736(19)30195-3 Summary Background 背景 Acute stroke due to supratentorial intracerebral haemorrhage is associated with high morbidity and ...

Venovenous extracorporeal membrane oxygenation for acute respiratory distress syndrome: a systematic review and meta-analysis Laveena Munshi, Allan Walkey, Ewan Goligher, et al Lancet Respir Med 2019; 7: 163-172 Background 背景 Use of extracorporeal membrane oxygenation (ECMO) in adults with severe acute respiratory distress syndrome has increased in the past 10 years. However, the efficacy of venovenous ECMO in people with acute respiratory distress synd...

Research Impact of scribes on emergency medicine doctors’ productivity and patient throughput: multicentre randomised trial Katherine Walker, Michael Ben-Meir, William Dunlop, et al https://doi.org/10.1136/bmj.l121  BMJ 2019;364:l121 Abstract Objectives 目的 To evaluate the changes in productivity when scribes were used by emergency physicians in emergency departments in Australia and assess the effect of scribes on throughput. 评估澳大利亚急诊科医...

Omadacycline for Community-Acquired Bacterial Pneumonia Roman Stets, Monica Popescu, Joven R. Gonong, et al N Engl J Med 2019; 380:517-527DOI: 10.1056/NEJMoa1800201 Abstract BACKGROUND 背景 Omadacycline, a new once-daily aminomethylcycline antibiotic agent that can be administered intravenously or orally, reaches high concentrations in pulmonary tissues and is active against common pathogens that cause community-acquired bacterial pneumonia. Omadacy...

Original Investigation February 12, 2019 Association of Left Ventricular Ejection Fraction and Symptoms With Mortality After Elective Noncardiac Surgery Among Patients With Heart Failure Benjamin J. Lerman, Rita A. Popat, Themistocles L. Assimes, et al JAMA. 2019;321(6):572-579. doi:10.1001/jama.2019.0156 Abstract Importance   Heart failure is an established risk factor for postoperative mortality, but how left ventricular ejection fractio...

ARTICLES Paediatric acute respiratory distress syndrome incidence and epidemiology (PARDIE): an international, observational study Robinder G Khemani, Lincoln Smith, Yolanda M Lopez-Fernandez, et al Lancet Respir Med 2019; 7: 115-128 Background 背景 Paediatric acute respiratory distress syndrome (PARDS) is associated with high mortality in children, but until recently no paediatric-specific diagnostic criteria existed. The Pediatric Acute Lung Injury C...

Prehospital transdermal glyceryl trinitrate in patients with ultra-acute presumed stroke (RIGHT-2): an ambulance-based, randomised, sham-controlled, blinded, phase 3 trial The RIGHT-2 Investigators Lancet Published:February 06, 2019 DOI:https://doi.org/10.1016/S0140-6736(19)30194-1 Summary Background 背景 High blood pressure is common in acute stroke and is a predictor of poor outcome; however, large trials of lowering blood pressure have given variable res...

Intensive Care Medicine ONLINE FIRST (FREE ACCESS)  ORIGINAL ~ The SIC (Simple Intensive Care) Studies-I - cardiac index - diagnostic accuracyHiemstra B, Koster G, Wiersema R, Hummel YM, van der Harst P, Snieder H, Eck RJ, Kaufmann T, Scheeren TWL, Perner A, Wetterslev J, de Smet AMGA, Keus F, van der Horst ICC; SICS Study Group.The diagnostic accuracy of clinical examination for estimating cardiac index in critically ill patients: the Simple Inte...

Original Investigation | February 18, 2019 Effect of a Nurse-Led Preventive Psychological Intervention on Symptoms of Posttraumatic Stress Disorder Among Critically Ill Patients: A Randomized Clinical Trial Dorothy M. Wade, Paul R. Mouncey, Alvin Richards-Belle, et al JAMA. 2019;321(7):665-675. doi:10.1001/jama.2019.0073 Abstract Importance 背景 A meta-analysis of outcomes during the 6 months after intens...