ARTICLES| VOLUME 7, ISSUE 8, P699-709, AUGUST 01, 2019 Eosinophil-guided corticosteroid therapy in patients admitted to hospital with COPD exacerbation (CORTICO-COP): a multicentre, randomised, controlled, open-label, non-inferiority trial Pradeesh Sivapalan, Therese S Lapperre, Julie Janner, et al. Lancet Respir Med 2019; 7: 699-709 DOI:https://doi.org/10.1016/S2213-2600(19)30176-6 Summary Background 背景 Treatment with systemic corticost...

ORIGINAL ARTICLE Ambient Particulate Air Pollution and Daily Mortality in 652 Cities Cong Liu, Renjie Chen, Francesco Sera, et al Abstract BACKGROUND 背景 The systematic evaluation of the results of time-series studies of air pollution is challenged by differences in model specification and publication bias. 由于模型特征的差异以及发表偏倚，系统评估大气污染的时间序列研究受到挑战。 METHODS 方法学 We evaluated the associations of inhalable particulate...

ICU Management & Practice, Volume 18 - Issue 1, 2018 “Simulate, or not to simulate?” Evolution in medicine and the anaesthesia context.  A brief discussion about the importance and the state of the art of simulation in anaesthesia and intensive care medicine. Training in simulation plays a key role in complex systems such as aviation and the nuclear industry, to investigate predictable errors that lead to adverse outcomes. The advancement made by...

ORIGINAL ARTICLE Effects of Serelaxin in Patients with Acute Heart Failure Marco Metra, John R. Teerlink, Gad Cotter, et al N Engl J Med 2019; 381:716-726DOI: 10.1056/NEJMoa1801291 Abstract BACKGROUND 背景 Serelaxin is a recombinant form of human relaxin-2, a vasodilator hormone that contributes to cardiovascular and renal adaptations during pregnancy. Previous studies have suggested that treatment with serelaxin may result in relief of symptoms and in b...

ORIGINAL ARTICLE Myocardial Viability and Long-Term Outcomes in Ischemic Cardiomyopathy Julio A. Panza, Alicia M. Ellis, Hussein R. Al-Khalidi, et al N Engl J Med 2019; 381:739-748DOI: 10.1056/NEJMoa1807365 Abstract BACKGROUND 背景 The role of assessment of myocardial viability in identifying patients with ischemic cardiomyopathy who might benefit from surgical revascularization remains controversial. Furthermore, although improvement in left ventricular...

ICU Management & Practice, Volume 19 - Issue 2, 2019 Infographic: Caring for the critically ill child

ARTICLES|ONLINE FIRST Mechanical and oral antibiotic bowel preparation versus no bowel preparation for elective colectomy (MOBILE): a multicentre, randomised, parallel, single-blinded trial Laura Koskenvuo, Taru Lehtonen, Selja Koskensalo, et al Lancet epub August 08, 2019 DOI:https://doi.org/10.1016/S0140-6736(19)31269-3 Summary Background 背景 Decreased surgical site infections (SSIs) and morbidity have been reported with mechanical and oral antibiotic...

ARTICLES|ONLINE FIRST Perioperative covert stroke in patients undergoing non-cardiac surgery (NeuroVISION): a prospective cohort study The NeuroVISION Investigators Lancet epub August 15, 2019 DOI:https://doi.org/10.1016/S0140-6736(19)31795-7 Summary Background 背景 In non-surgical settings, covert stroke is more common than overt stroke and is associated with cognitive decline. Although overt stroke occurs in less than 1% of adults after non-cardiac sur...

ARTICLES|ONLINE FIRST An artificial intelligence-enabled ECG algorithm for the identification of patients with atrial fibrillation during sinus rhythm: a retrospective analysis of outcome prediction Zachi I Attia, Peter A Noseworthy, Francisco Lopez-Jimenez, et al Lancet Published:August 01, 2019 DOI:https://doi.org/10.1016/S0140-6736(19)31721-0 Summary Background 背景 Atrial fibrillation is frequently asymptomatic and thus underdetected but is asso...

Letter | Published: 31 July 2019 A clinically applicable approach to continuous prediction of future acute kidney injury Nenad Tomašev, Xavier Glorot, Jack W. Rae, et al Nature  572, pages116–119 (2019) Abstract The early prediction of deterioration could have an important role in supporting healthcare professionals, as an estimated 11% of deaths in hospital follow a failure to promptly recognize and treat deteri...