#LIVES2019: Findings from the DIANA Study Liesbet De Bus of Ghent University Hospital, Belgium, presented the findings of the DetermInants of Antimicrobial use aNd de-escalAtion (DIANA) study @ESICM #LIVES2019 in Berlin. Dr. De Bus started off by explaining the concept of de-escalation and how it is all about finding a balance between early adequate antimicrobial therapy on the one hand and reducing unnecessary exposure to antimicrobials on the other hand, mainl...

Original Investigation Caring for the Critically Ill PatientOctober 2, 2019 Effect of Selepressin vs Placebo on Ventilator- and Vasopressor-Free Days in Patients With Septic Shock: The SEPSIS-ACT Randomized Clinical Trial Pierre-Francois Laterre, Scott M. Berry, Allan Blemings, et al JAMA. Published online October 2, 2019. doi:10.1001/jama.2019.14607 Importance 背景 Norepinephrine, the first-line vasopr...

#LIVES2019: Findings from the NONSEDA Study Palle Toft of Odense University Hospital presented the findings of the “No sedation compared to sedation with a daily wake-up trial. A prospective randomized multicentre study - The NONSEDA-study” @ESICM in Berlin. The NON-SEDA study is a Scandinavian multicentre study conducted in Denmark, Norway, and Sweden that compared non-sedation with light sedation or arousable sedation. Only 8 intensive care units were included, b...

ARTICLES|ONLINE FIRST Antibiotic or silver versus standard ventriculoperitoneal shunts (BASICS): a multicentre, single-blinded, randomised trial and economic evaluation Conor L Mallucci, Michael D Jenkinson, Elizabeth J Conroy, et al Lancet Published:September 12, 2019 DOI:https://doi.org/10.1016/S0140-6736(19)31603-4 Summary Background 背景 Insertion of a ventriculoperitoneal shunt for hydrocephalus is one of the commonest neurosurgical procedures world...

#LIVES2019: Highlights from the Opening Ceremony @ESICM The 32nd Annual Congress of ESICM officially opened today at the CityCube in Berlin. At the #LIVES2019 opening ceremony, Jozef Kesecioglu, ESICM President, welcomed all participants. Prof. Kesecioglu offered his thanks to the ESICM team, office members and the executive committee members for their efforts during the last twelve months. He then talked about the creation of a new section in the society – The ...

Research Letter September 3, 2019 Incidence of Maternal Sepsis and Sepsis-Related Maternal Deaths in the United States Matthew K. Hensley, Melissa E. Bauer, Lindsay K. Admon, et al. JAMA. 2019;322(9):890-892. doi:10.1001/jama.2019.9818 Results From 63 665 593 hospitalizations in the NRD (2013-2016), there were 5 957 678 delivery hospitalizations with discharges in January through October, of which 32.5% were...

Original Investigation September 3, 2019 Effect of Low-Intensity vs Standard-Intensity Warfarin Prophylaxis on Venous Thromboembolism or Death Among Patients Undergoing Hip or Knee Arthroplasty: A Randomized Clinical Trial Brian F. Gage, Anne R. Bass, Hannah Lin, et al JAMA. 2019;322(9):834-842. doi:10.1001/jama.2019.12085 Abstract Importance 背景 The optimal international normalized ratio (INR) to preven...

ARTICLES|ONLINE FIRST Personalised mechanical ventilation tailored to lung morphology versus low positive end-expiratory pressure for patients with acute respiratory distress syndrome in France (the LIVE study): a multicentre, single-blind, randomised controlled trial Jean-Michel Constantin, Matthieu Jabaudon, Jean-Yves Lefrant, et al Lancet Respir Med Published:August 06, 2019 DOI:https://doi.org/10.1016/S2213-2600(19)30138-9 Summary Background The effe...

ARTICLES|ONLINE FIRST Contact precautions in single-bed or multiple-bed rooms for patients with extended-spectrum β-lactamase-producing Enterobacteriaceae in Dutch hospitals: a cluster-randomised, crossover, non-inferiority study Marjolein F Q Kluytmans-van den Bergh, Patricia C J Bruijning-Verhagen, Prof Christina M J E Vandenbroucke-Grauls, et al. Lancet Infect Dis Published:August 23, 2019 DOI:https://doi.org/10.1016/S1473-3099(19)30262-2 Summary Backgro...

Original Investigation September 3, 2019 N95 Respirators vs Medical Masks for Preventing Influenza Among Health Care Personnel: A Randomized Clinical Trial Lewis J. Radonovich Jr, Michael S. Simberkoff, Mary T. Bessesen, et al JAMA. 2019;322(9):824-833. doi:10.1001/jama.2019.11645 Abstract Importance 背景 Clinical studies have been inconclusive about the effectiveness of N95 respirators and medical m...