Original Investigation Mobile Photoplethysmographic Technology to Detect Atrial Fibrillation Guo Y, Wang H, Zhang H, et al J Am Coll Cardiol. 2019 Nov 12;74(19):2365-2375. doi: 10.1016/j.jacc.2019.08.019 Background Low detection and nonadherence are major problems in current management approaches for patients with suspected atrial fibrillation (AF). Mobile health devices may enable earlier AF detection and improved AF management. Objectives This study...

Research Methods & Reporting A guide to prospective meta-analysis Anna Lene Seidler, Kylie E Hunter, Saskia Cheyne, et al BMJ 2019; 367: l5342 DOI:https://doi.org/10.1136/bmj.l5342 Summary points In a prospective meta-analysis (PMA), studies are identified and determined to be eligible for inclusion before the results of the studies related to the PMA research question are knownPMAs are applicable to high priority research questions where limited previo...

ORIGINAL ARTICLE Large-Scale Assessment of a Smartwatch to Identify Atrial Fibrillation Marco V. Perez, Kenneth W. Mahaffey, Haley Hedlin, et al. N Engl J Med 2019; 381:1909-1917DOI: 10.1056/NEJMoa1901183 BACKGROUND Optical sensors on wearable devices can detect irregular pulses. The ability of a smartwatch application (app) to identify atrial fibrillation during typical use is unknown. METHODS Participants without atrial fibrillation (as reported by ...

ARTICLES|ONLINE FIRST Ceftolozane–tazobactam versus meropenem for treatment of nosocomial pneumonia (ASPECT-NP): a randomised, controlled, double-blind, phase 3, non-inferiority trial Marin H Kollef, Martin Nováček, Ülo Kivistik, et al Lancet Infect Dis September 25, 2019 DOI:https://doi.org/10.1016/S1473-3099(19)30403-7 Summary Background 背景 Nosocomial pneumonia due to antimicrobial-resistant pathogens is associated with high mortality. We assessed th...

ICU Management & Practice, Volume 18 - Issue 1, 2018 Immune dysfunction in sepsis An overview of the recent advances in the diagnosis and treatment of immune system dysfunction in sepsis. Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection (Singer et al. 2016). Sepsis-induced immune system dysfunction is an important sequelae of sepsis. The persistence of immune system dysfunction in the later stage...

Original Investigation August 28, 2019 Effect of Low-Dose Supplementation of Arginine Vasopressin on Need for Blood Product Transfusions in Patients With Trauma and Hemorrhagic Shock: A Randomized Clinical Trial Carrie A. Sims, Daniel Holena, Patrick Kim, et al JAMA Surg. Published online August 28, 2019. doi:10.1001/jamasurg.2019.2884 Importance 背景 Current therapies for traumatic blood loss focus on hemor...

Original Investigation Critical Care MedicineAugust 7, 2019 Long-term Host Immune Response Trajectories Among Hospitalized Patients With Sepsis Sachin Yende, John A. Kellum, Victor B. Talisa, et al JAMA Netw Open. 2019;2(8):e198686. doi:10.1001/jamanetworkopen.2019.8686 Importance 背景 Long-term immune sequelae after sepsis are poorly understood. 脓毒症后长期免疫后遗症尚未明确。 Objective 目的 To as...

ARTICLES|ONLINE FIRST Effects of tranexamic acid on death, disability, vascular occlusive events and other morbidities in patients with acute traumatic brain injury (CRASH-3): a randomised, placebo-controlled trial The CRASH-3 trial collaborators Lancet Published:October 14, 2019 DOI:https://doi.org/10.1016/S0140-6736(19)32233-0 Background 背景 Tranexamic acid reduces surgical bleeding and decreases mortality in patients with traumatic extracranial bleeding...

ARTICLES|ONLINE FIRST Effect of remote ischaemic conditioning on clinical outcomes in patients with acute myocardial infarction (CONDI-2/ERIC-PPCI): a single-blind randomised controlled trial Derek J Hausenloy, Rajesh K Kharbanda, Ulla Kristine Møller, et al. Lancet Published:September 06, 2019 DOI:https://doi.org/10.1016/S0140-6736(19)32039-2 Summary Background 背景 Remote ischaemic conditioning with transient ischaemia and reperfusion applied to t...

Original Investigation October 8, 2019 Association of Surgical Hematoma Evacuation vs Conservative Treatment With Functional Outcome in Patients With Cerebellar Intracerebral Hemorrhage Joji B. Kuramatsu, Alessandro Biffi, Stefan T. Gerner, et al JAMA. 2019;322(14):1392-1403. doi:10.1001/jama.2019.13014 Importance 背景 The association of surgical hematoma evacuation with clinical outcomes in patients with cerebellar intracerebral hemorrhage (...