Research Estimates of all cause mortality and cause specific mortality associated with proton pump inhibitors among US veterans: cohort study BMJ 2019; 365: l1580 https://doi.org/10.1136/bmj.l1580 Abstract Objective 目的 To estimate all cause mortality and cause specific mortality among patients taking proton pump inhibitors (PPIs). 估算服用质子泵抑制剂(PPI)患者的全因病死率及疾病特异性病死率。 Design 试验设计 Longitudinal o...

Research Intensive care use and mortality among patients with ST elevation myocardial infarction: retrospective cohort study BMJ 2019; 365: l1927 https://doi.org/10.1136/bmj.l1927 Cite this as: BMJ 2019;365:l1927 Abstract Objective 目的 To evaluate the effect of intensive care unit (ICU) admission on mortality among patients with ST elevation myocardial infarction (STEMI). 评价收治ICU对STEMI患者病死率的影响 Design 试验...

Original Investigation Effect of Intraoperative High Positive End-Expiratory Pressure (PEEP) With Recruitment Maneuvers vs Low PEEP on Postoperative Pulmonary Complications in Obese Patients: A Randomized Clinical Trial Writing Committee for the PROBESE Collaborative Group of the PROtective VEntilation Network (PROVEnet) for the Clinical Trial Network of the European Society of Anaesthesiology JAMA. 2019;321(23):2292-2305. doi:10.1001/jama.2019.7505 Abstract ...

ORIGINAL ARTICLE Clinical Metagenomic Sequencing for Diagnosis of Meningitis and Encephalitis Michael R. Wilson, Hannah A. Sample, Kelsey C. Zorn, et al N Engl J Med 2019; 380:2327-2340DOI: 10.1056/NEJMoa1803396  Abstract BACKGROUND 背景 Metagenomic next-generation sequencing (NGS) of cerebrospinal fluid (CSF) has the potential to identify a broad range of pathogens in a single test. 脑脊液(CSF)的宏基因二代测序(NGS)能够通过一次检测鉴别多种致病微...

Original Investigation June 11, 2019 Association of Blood Donor Sex and Prior Pregnancy With Mortality Among Red Blood Cell Transfusion Recipients Gustaf Edgren Edward L. Murphy, Don J. Brambilla, et al JAMA. 2019;321(22):2183-2192. doi:10.1001/jama.2019.7084 Abstract 摘要 Importance 背景 Evidence regarding associations of blood donor sex with mortality among red blood cell transfusion recipients is conflicting. 有关献血者性别与接受输血...

Effect of ultra-short-term treatment of patients with iron deficiency or anaemia undergoing cardiac surgery: a prospective randomised trial Donat R Spahn, Felix Schoenrath, Gabriela H Spahn, et al Lancet 2019; 393: 2201-2212 DOI:https://doi.org/10.1016/S0140-6736(18)32555-8 Summary Background 背景 Anaemia and iron deficiency are frequent in patients scheduled for cardiac surgery. This study assessed whether immediate preoperative treatment could result...

Original Investigation June 11, 2019 Effect of Pressure Support vs T-Piece Ventilation Strategies During Spontaneous Breathing Trials on Successful Extubation Among Patients Receiving Mechanical Ventilation: A Randomized Clinical Trial Carles Subirà, Gonzalo Hernández, Antònia Vázquez, et al JAMA. 2019;321(22):2175-2182. doi:10.1001/jama.2019.7234Key Points Objective 目的 To evaluate the effect of an SBT consisting of 30 minutes of pressure support ventilat...

Individualised nutritional support in medical inpatients at nutritional risk: a randomised clinical trial Philipp Schuetz, Rebecca Fehr, Valerie Baechli, et al Lancet 2019 Published:April 25, 2019 DOI:https://doi.org/10.1016/S0140-6736(18)32776-4 Summary Background 背景 Guidelines recommend the use of nutritional support during hospital stays for medical patients (patients not critically ill and not undergoing surgical procedures) at risk of malnutrition...

ARTICLES OF THE MONTH - MAY 2019 SEVEN-DAY PROFILE PUBLICATION ~Feasibility and safety of extracorporeal CO2 removal to enhance protective ventilation in acute respiratory distress syndrome: the SUPERNOVA study Combes A. et al:Feasibility and safety of extracorporeal CO2 removal to enhance protective ventilation in acute respiratory distress syndrome: the SUPERNOVA study The SUPERNOVA study assessed feasibility and safety of extracorporeal carbon dioxide remo...

ARTICLES|ONLINE FIRST Effect of carbapenem resistance on outcomes of bloodstream infection caused by Enterobacteriaceae in low-income and middle-income countries (PANORAMA): a multinational prospective cohort study Andrew J Stewardson, Kalisvar Marimuthu, Sharmila Sengupta, et al Lancet Infect Dis Published: April 29, 2019 DOI:https://doi.org/10.1016/S1473-3099(18)30792-8 Summary Background 背景 Low-income and middle-income countries (LMICs) are under...