ORIGINAL ARTICLE Immediate Transfusion in African Children with Uncomplicated Severe Anemia Kathryn Maitland, Sarah Kiguli, Peter Olupot-Olupot, et al. N Engl J Med 2019; 381:407-419DOI: 10.1056/NEJMoa1900105 Abstract BACKGROUND 背景 The World Health Organization recommends not performing transfusions in African children hospitalized for uncomplicated severe anemia (hemoglobin level of 4 to 6 g per deciliter and no signs of clinical severity). Howev...

Research Diagnosis of elevated intracranial pressure in critically ill adults: systematic review and meta-analysis Shannon M Fernando, Alexandre Tran, Wei Cheng, et al BMJ 2019;366:l4225 Abstract Objectives 背景 To summarise and compare the accuracy of physical examination, computed tomography (CT), sonography of the optic nerve sheath diameter (ONSD), and transcranial Doppler pulsatility index (TCD-PI) for the diagnosis of elevated intracranial pressure...

ORIGINAL ARTICLE A Multicenter Trial of Vena Cava Filters in Severely Injured Patients Kwok M. Ho, Sudhakar Rao, Stephen Honeybul, et al N Engl J Med 2019; 381:328-337DOI: 10.1056/NEJMoa1806515 Abstract BACKGROUND 背景 Whether early placement of an inferior vena cava filter reduces the risk of pulmonary embolism or death in severely injured patients who have a contraindication to prophylactic anticoagulation is not known. 对于具有预防性抗凝禁忌的严重...

Original Investigation | July 23/30, 2019 Intensive vs Standard Treatment of Hyperglycemia and Functional Outcome in Patients With Acute Ischemic Stroke: The SHINE Randomized Clinical Trial Karen C. Johnston, Askiel Bruno, Qi Pauls, et al JAMA. 2019;322(4):326-335. doi:10.1001/jama.2019.9346 Abstract Importance 背景 Hyperglycemia during acute ischemic stroke is common and is associated with worse out...

Original Investigation  Association Between State-Mandated Protocolized Sepsis Care and In-hospital Mortality Among Adults With Sepsis Jeremy M. Kahn, Billie S. Davis, Jonathan G. Yabes, et al JAMA. 2019;322(3):240-250. doi:10.1001/jama.2019.9021 Abstract Importance 背景 Beginning in 2013, New York State implemented regulations mandating that hospitals implement evidence-based protocols for sepsis management, ...

Original Investigation | Caring for the Critically Ill Patient Effect of an ICU Diary on Posttraumatic Stress Disorder Symptoms Among Patients Receiving Mechanical Ventilation: A Randomized Clinical Trial Maité Garrouste-Orgeas, Cécile Flahault, Isabelle Vinatier, et al JAMA. 2019;322(3):229-239. doi:10.1001/jama.2019.9058 Abstract Importance 背景 Keeping a diary for patients while they are in the intensive ca...

ICU Management & Practice, Volume 19 - Issue 1, 2019 Technology innovations in delivering accurate nutrition Preventing malnutrition and enforcing nutritional guidelines An overview of the key obstacles for the enforcement of nutritional guidelines and innovative approaches that can be used to overcome these obstacles. Recent studies suggest that nutritional guidelines across the majority of intensive care units (ICUs) are not being implemented (Benda...

Original Investigation | Caring for the Critically Ill Patient Effect of Flexible Family Visitation on Delirium Among Patients in the Intensive Care Unit: The ICU Visits Randomized Clinical Trial Regis Goulart Rosa, Maicon Falavigna, Daiana Barbosa da Silva, et al JAMA. 2019;322(3):216-228. doi:10.1001/jama.2019.8766 Abstract Importance 背景 The effects of intensive care unit (ICU) visiting hours remain uncert...

ARTICLES|ONLINE FIRST Arginine-stimulated copeptin measurements in the differential diagnosis of diabetes insipidus: a prospective diagnostic study Bettina Winzeler, Nicole Cesana-Nigro, Julie Refardt, et al Lancet Published: July 11, 2019 DOI:https://doi.org/10.1016/S0140-6736(19)31255-3 Summary Background 背景 Differential diagnosis of diabetes insipidus is challenging. The most reliable approach is hypertonic saline-stimulated copeptin measurements. H...

Research Association of changes in red meat consumption with total and cause specific mortality among US women and men: two prospective cohort studies Yan Zheng, Yanping Li, Ambika Satija, et al BMJ 2019; 365: l2110 doi:https://doi.org/10.1136/bmj.l2110 Abstract Objective 目的 To evaluate the association of changes in red meat consumption with total and cause specific mortality in women and men. 评价红肉摄入的改变对女性和男性全因死亡率与疾病特异性死亡...