ICU Management & Practice, Volume 18 - Issue 1, 2018 “Simulate, or not to simulate?” Evolution in medicine and the anaesthesia context.  A brief discussion about the importance and the state of the art of simulation in anaesthesia and intensive care medicine. Training in simulation plays a key role in complex systems such as aviation and the nuclear industry, to investigate predictable errors that lead to adverse outcomes. The advancement made by...

ORIGINAL ARTICLE Effects of Serelaxin in Patients with Acute Heart Failure Marco Metra, John R. Teerlink, Gad Cotter, et al N Engl J Med 2019; 381:716-726DOI: 10.1056/NEJMoa1801291 Abstract BACKGROUND 背景 Serelaxin is a recombinant form of human relaxin-2, a vasodilator hormone that contributes to cardiovascular and renal adaptations during pregnancy. Previous studies have suggested that treatment with serelaxin may result in relief of symptoms and in b...

ORIGINAL ARTICLE Myocardial Viability and Long-Term Outcomes in Ischemic Cardiomyopathy Julio A. Panza, Alicia M. Ellis, Hussein R. Al-Khalidi, et al N Engl J Med 2019; 381:739-748DOI: 10.1056/NEJMoa1807365 Abstract BACKGROUND 背景 The role of assessment of myocardial viability in identifying patients with ischemic cardiomyopathy who might benefit from surgical revascularization remains controversial. Furthermore, although improvement in left ventricular...

ICU Management & Practice, Volume 19 - Issue 2, 2019 Infographic: Caring for the critically ill child

ARTICLES|ONLINE FIRST Mechanical and oral antibiotic bowel preparation versus no bowel preparation for elective colectomy (MOBILE): a multicentre, randomised, parallel, single-blinded trial Laura Koskenvuo, Taru Lehtonen, Selja Koskensalo, et al Lancet epub August 08, 2019 DOI:https://doi.org/10.1016/S0140-6736(19)31269-3 Summary Background 背景 Decreased surgical site infections (SSIs) and morbidity have been reported with mechanical and oral antibiotic...

ARTICLES|ONLINE FIRST Perioperative covert stroke in patients undergoing non-cardiac surgery (NeuroVISION): a prospective cohort study The NeuroVISION Investigators Lancet epub August 15, 2019 DOI:https://doi.org/10.1016/S0140-6736(19)31795-7 Summary Background 背景 In non-surgical settings, covert stroke is more common than overt stroke and is associated with cognitive decline. Although overt stroke occurs in less than 1% of adults after non-cardiac sur...

ARTICLES|ONLINE FIRST An artificial intelligence-enabled ECG algorithm for the identification of patients with atrial fibrillation during sinus rhythm: a retrospective analysis of outcome prediction Zachi I Attia, Peter A Noseworthy, Francisco Lopez-Jimenez, et al Lancet Published:August 01, 2019 DOI:https://doi.org/10.1016/S0140-6736(19)31721-0 Summary Background 背景 Atrial fibrillation is frequently asymptomatic and thus underdetected but is asso...

Letter | Published: 31 July 2019 A clinically applicable approach to continuous prediction of future acute kidney injury Nenad Tomašev, Xavier Glorot, Jack W. Rae, et al Nature  572, pages116–119 (2019) Abstract The early prediction of deterioration could have an important role in supporting healthcare professionals, as an estimated 11% of deaths in hospital follow a failure to promptly recognize and treat deteri...

ORIGINAL ARTICLE Transfusion Volume for Children with Severe Anemia in Africa Kathryn Maitland, Peter Olupot-Olupot, Sarah Kiguli, et al N Engl J Med 2019; 381:420-431DOI: 10.1056/NEJMoa1900100 Abstract BACKGROUND 背景 Severe anemia (hemoglobin level, <6 g per deciliter) is a leading cause of hospital admission and death in children in sub-Saharan Africa. The World Health Organization recommends transfusion of 20 ml of whole-blood equivalent per ...

Review August 13, 2019 Extracorporeal Life Support for Adults With Respiratory Failure and Related Indications: A Review Daniel Brodie, Arthur S. Slutsky, Alain Combes JAMA. 2019;322(6):557-568. doi:10.1001/jama.2019.9302