ICU Management & Practice, Volume 20 - Issue 3, 2020 Lessons From the “Very Old Intensive Care Patients” (VIP) Project An overview of the VIP project that studies a subgroup of patients ≥ 80 years, the oldest old, since both ICU mortality and morbidity are increased with advanced age. During the last 10 years, we have observed an increased interest in research into our oldest intensive care patients. This is brought forward with the expectation...

ORIGINAL ARTICLE Interferon Beta-1b and Lopinavir–Ritonavir for Middle East Respiratory Syndrome Yaseen M. Arabi, Ayed Y. Asiri, Abdullah M. Assiri, et al N Engl J Med October 7, 2020DOI: 10.1056/NEJMoa2015294 Abstract 摘要 BACKGROUND 背景 Whether combined treatment with recombinant interferon beta-1b and lopinavir–ritonavir reduces mortality among patients hospitalized with Middle East respiratory syndrome (MERS) is unclear. 重组beta-1b干扰素与克立芝...

ARTICLES|ONLINE FIRST Azithromycin in addition to standard of care versus standard of care alone in the treatment of patients admitted to the hospital with severe COVID-19 in Brazil (COALITION II): a randomised clinical trial Remo H M Furtado, Otavio Berwanger, Henrique A Fonseca, et al Lancet Published:September 04, 2020 DOI:https://doi.org/10.1016/S0140-6736(20)31862-6 Summary 摘要 Background 背景 The efficacy and safety of azithromycin in the treatmen...

ARTICLES|ONLINE FIRST Preoperative intravenous iron to treat anaemia before major abdominal surgery (PREVENTT): a randomised, double-blind, controlled trial Toby Richards, Ravishankar Rao Baikady, Ben Clevenger, et al Lancet Published:September 04, 2020 DOI:https://doi.org/10.1016/S0140-6736(20)31539-7 Summary 摘要 Background 背景 Preoperative anaemia affects a high proportion of patients undergoing major elective surgery and is associated with poor outc...

HealthManagement, Volume 20 - Issue 5, 2020 COVID-19 Antibody Testing – Why it Matters and Factors to Consider As we move into the next phase of the COVID-19 pandemic, there will be a need to test a broad strata of population, much more than what molecular tests can handle. The solution lies with serological tests. As the world continues the fight against COVID-19, healthcare executives are in an uncomfortable position – having to make critical decisions wit...

PulmCrit – Splitting ventilators to provide titrated support to a large group of patients March 15, 2020 by Josh Farkas COVID-19 might out-strip the number of mechanical ventilators available to us.  This has led to interest in using a single ventilator to support multiple patients.  This post will review the theory and evidence regarding this (with the admission that I don’t have experience with this).  basic principles Bedrock principle: ...

ARTICLES|ONLINE FIRST Defining persistent Staphylococcus aureus bacteraemia: secondary analysis of a prospective cohort study Richard Kuehl, Laura Morata, Christian Boeing, et al Lancet Infect Dis Published:August 04, 2020 DOI:https://doi.org/10.1016/S1473-3099(20)30447-3 Summary 摘要 Background 背景 Staphylococcus aureus persistent bacteraemia is only vaguely defined and the effect of different durations of bacteraemia on mortality is not well establish...

ICU Management & Practice, Volume 20 - Issue 2, 2020 Is COVID-19 the Black Swan? Nassim Taleb, in his book, "The Black Swan: The Impact of the Highly Improbable," describes the term Black Swan as a rare, unknown event, which with hindsight is rationalised. Taleb talks about the human tendency to always find simplistic explanations for unknown events, what he calls the Black Swan theory. Is COVID-19 a black swan? Introduction Physicians working with cr...

ARTICLES| VOLUME 396, ISSUE 10251, P603-611, AUGUST 29, 2020 Effects of a major deletion in the SARS-CoV-2 genome on the severity of infection and the inflammatory response: an observational cohort study Barnaby E Young, Siew-Wai Fong, Yi-Hao Chan, et al Lancet 2020; 396: 603-611 Summary 摘要 Background 背景 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants with a 382-nucleotide deletion (∆382) in the open reading frame 8 (ORF8) regio...

COVID-19-associated hyperinflammation and escalation of patient care: a retrospective longitudinal cohort study Jessica J Manson, Colin Crooks, Meena Naja, et al Lancet Rheumatol Published:August 21, 2020 DOI:https://doi.org/10.1016/S2665-9913(20)30275-7 Summary Background 背景 A subset of patients with severe COVID-19 develop a hyperinflammatory syndrome, which might contribute to morbidity and mortality. This study explores a specific phenotype of COVID-1...