Viewpoint April 6, 2020 The COVID-19 Pandemic in the USA: Clinical Update Saad B. Omer, Preeti Malani, Carlos del Rio JAMA. 2020;323(18):1767-1768. doi:10.1001/jama.2020.5788 Since the first US case of coronavirus disease 2019 (COVID-19) infection as identified in Washington State on January 20, 2020, more than 235 000 cases have been identified across the US in just over 2 months. Given the challenges in expanding testing capacity and the restrictive cas...

Delayed versus early initiation of renal replacement therapy for severe acute kidney injury: a systematic review and individual patient data meta-analysis of randomised clinical trials Lancet 2020; 395: 1506-1515 Summary Background The timing of renal replacement therapy (RRT) for severe acute kidney injury is highly debated when no life-threatening complications are present. We assessed whether a strategy of delayed versus early RRT initiation affects 28-day ...

CORRESPONDENCE Out-of-Hospital Cardiac Arrest during the Covid-19 Outbreak in Italy N Engl J Med April 29, 2020DOI: 10.1056/NEJMc2010418 TO THE EDITOR: Despite the risk of rapid respiratory failure1 and cardiac complications2 due to Covid-19, it is unclear whether there is an association between Covid-19 and out-of-hospital cardiac arrest. The Lombardy region of Italy was among the first areas to have an outbreak of Covid-19 outside China,3 and ...

Original Investigation May 11, 2020 Association of Treatment With Hydroxychloroquine or Azithromycin With In-Hospital Mortality in Patients With COVID-19 in New York State Eli S. Rosenberg, PElizabeth M. Dufort, Tomoko Udo, et al JAMA. Published online May 11, 2020. doi:10.1001/jama.2020.8630 Abstract Importance Hydroxychloroquine, with or without azithromycin, has been considered as a possible therapeutic agent for patients with coronavir...

ORIGINAL ARTICLE Observational Study of Hydroxychloroquine in Hospitalized Patients with Covid-19 Joshua Geleris, Yifei Sun, Jonathan Platt, et al N Engl J Med May 7, 2020DOI: 10.1056/NEJMoa2012410 Abstract BACKGROUND Hydroxychloroquine has been widely administered to patients with Covid-19 without robust evidence supporting its use. METHODS We examined the association between hydroxychloroquine use and intubation or death at a large medical center...

ARTICLES|ONLINE FIRST Interleukin-1 blockade with high-dose anakinra in patients with COVID-19, acute respiratory distress syndrome, and hyperinflammation: a retrospective cohort study Giulio Cavalli, Giacomo De Luca, Corrado Campochiaro, et al Lancet Rheumatol Published:May 07, 2020 DOI:https://doi.org/10.1016/S2665-9913(20)30127-2 Summary Background Mortality of patients with coronavirus disease 2019 (COVID-19), acute respiratory distress syndrome (ARD...

ARTICLES|ONLINE FIRST Triple combination of interferon beta-1b, lopinavir–ritonavir, and ribavirin in the treatment of patients admitted to hospital with COVID-19: an open-label, randomised, phase 2 trial Ivan Fan-Ngai Hung, Kwok-Cheung Lung, Eugene Yuk-Keung Tso, et al Lancet Published:May 08, 2020 DOI:https://doi.org/10.1016/S0140-6736(20)31042-4 Summary Background Effective antiviral therapy is important for tackling the coronavirus disease 2019 (COVI...

JAMA Insights Clinical UpdateMarch 11, 2020 Care for Critically Ill Patients With COVID-19 Srinivas Murthy, Charles D. Gomersall, Robert A. Fowler JAMA. 2020;323(15):1499-1500. doi:10.1001/jama.2020.3633 Initial reports suggest that COVID-19 is associated with severe disease that requires intensive care in approximately 5% of proven infections.1 Given how common the disease is becoming, as in prior major severe acute respiratory infection outbreaks—S...

Original Investigation April 22, 2020 Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area Safiya Richardson, Jamie S. Hirsch, Mangala Narasimhan, et al JAMA. Published online April 22, 2020. doi:10.1001/jama.2020.6775 Abstract Importance There is limited information describing the presenting characteristics and outcomes of US patients requiring hospitalization for...

May 6, 2020 Interpreting Diagnostic Tests for SARS-CoV-2 Nandini Sethuraman, Sundararaj Stanleyraj Jeremiah, Akihide Ryo JAMA. Published online May 6, 2020. doi:10.1001/jama.2020.8259 The pandemic of coronavirus disease 2019 (COVID-19) continues to affect much of the world. Knowledge of diagnostic tests for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is still evolving, and a clear understanding of the nature of the tests and interpre...