Biomarker-guided antibiotic stewardship in suspected ventilator-associated pneumonia (VAPrapid2): a randomised controlled trial and process evaluation Thomas P Hellyer, Daniel F McAuley, Timothy S Walsh, et al Lancet Respir Med December 03, 2019 DOI:https://doi.org/10.1016/S2213-2600(19)30367-4 Background Ventilator-associated pneumonia is the most common intensive care unit (ICU)-acquired infection, yet accurate diagnosis remains difficult, leading to overuse...

Research Christmas 2019: Express Yourself The art of life and death: 14 year follow-up analyses of associations between arts engagement and mortality in the English Longitudinal Study of Ageing Daisy Fancourt, Andrew Steptoe BMJ 2019;367:l6377 doi: https://doi.org/10.1136/bmj.l6377 (Published 18 December 2019) Abstract Objective 目的 To explore associations between different frequencies of arts engagement and mortality over ...

Research Christmas 2019: Shiny Happy People Working 9 to 5, not the way to make an academic living: observational analysis of manuscript and peer review submissions over time Adrian Barnett, Inger Mewburn, Sara Schroter BMJ 2019;367:l6460 doi: https://doi.org/10.1136/bmj.l6460 (Published 19 December 2019) Objective 目的 To determine whether researchers are submitting manuscripts and peer reviews to BMJ journals out of hours and whether this has changed...

Original Investigation December 17, 2019 Effect of a Strategy of Comprehensive Vasodilation vs Usual Care on Mortality and Heart Failure Rehospitalization Among Patients With Acute Heart Failure: The GALACTIC Randomized Clinical Trial Nikola Kozhuharov, Assen Goudev, Dayana Flores, et al JAMA. 2019;322(23):2292-2302. doi:10.1001/jama.2019.18598 Importance 背景 Short-term infusions of single vasodilators...

Research Christmas 2019: Let it Be Birth month, birth season, and overall and cardiovascular disease mortality in US women: prospective cohort study Yin Zhang,  Elizabeth E Devore, Susanne Strohmaier, et al BMJ 2019;367:l6058 doi: https://doi.org/10.1136/bmj.l6058 (Published 18 December 2019) Abstract Objectives 目的 To evaluate the associations between birth month, birth season, and overall and cardiovascular disease mortality, and to examine the r...

Research |Christmas 2019: Shiny Happy People Political events and mood among young physicians: a prospective cohort study BMJ 2019; 367: l6322 doi: https://doi.org/10.1136/bmj.l6322

Original Investigation December 17, 2019 Effect of Rocuronium vs Succinylcholine on Endotracheal Intubation Success Rate Among Patients Undergoing Out-of-Hospital Rapid Sequence IntubationA Randomized Clinical Trial Bertrand Guihard, Charlotte Chollet-Xémard, Philippe Lakhnati, et al JAMA. 2019;322(23):2303-2312. doi:10.1001/jama.2019.18254 Importance 背景 Rocuronium and succinylcholine are often used for ra...

Research Christmas 2019: Chasing Cars The need for speed: observational study of physician driving behaviors André Zimerman, Christopher Worsham, Jaemin Woo, et al BMJ 2019; 367: l6354 doi: https://doi.org/10.1136/bmj.l6354 (Published 18 December 2019) Abstract Objective 目的 To determine whether fast driving, luxury car ownership, and leniency by police officers differ across medical specialties. 确定不同医学专业间超速行驶、拥有豪车情况以及受到...

ARTICLES|ONLINE FIRST Oseltamivir plus usual care versus usual care for influenza-like illness in primary care: an open-label, pragmatic, randomised controlled trial Christopher C Butler, Alike W van der Velden, Emily Bongard, et al Lancet Published: December 12, 2019 DOI:https://doi.org/10.1016/S0140-6736(19)32982-4 Background 背景 Antivirals are infrequently prescribed in European primary care for influenza-like illness, mostly because of perceived ineffe...

Anti-influenza Hyperimmune Intravenous Immunoglobulin for Adults With Influenza A or B Infection (FLU-IVIG): A Double-Blind, Randomised, Placebo-Controlled Trial Richard T Davey Jr, Eduardo Fernández-Cruz, Norman Markowitz, et al Lancet Respir Med 2019; 7: 951-963 Background 背景 Since the 1918 influenza pandemic, non-randomised studies and small clinical trials have suggested that convalescent plasma or anti-influenza hyperimmune intravenous immunoglobulin (h...