Original Investigation February 17, 2020 Effect of Intravenous Interferon β-1a on Death and Days Free From Mechanical Ventilation Among Patients With Moderate to Severe Acute Respiratory Distress Syndrome: A Randomized Clinical Trial V. Marco Ranieri,  Ville Pettilä, Matti K. Karvonen, et al JAMA. Published online February 17, 2020. doi:10.1001/jama.2019.22525 Abstract Importance Acute respiratory distress syndrome (ARDS) is associated wit...

ICU Management & Practice, Volume 19 - Issue 3, 2019 Challenges in the Management of the Critically Ill Patient Interview with Massimo Antonelli, Professor of Intensive Care and Anaesthesiology, Università Cattolica del Sacro Cuore, Rome, Italy Massimo Antonelli is a Professor of Intensive Care and Anesthesiology at the Università Cattolica del Sacro Cuore, Rome, Italy. He serves as the Director of the Dept. of Anesthesiology and Intensive Care and ...

ORIGINAL ARTICLE A Randomized Trial of Erythropoietin for Neuroprotection in Preterm Infants Sandra E. Juul, Bryan A. Comstock, Rajan Wadhawan, et al N Engl J Med 2020; 382:233-243DOI: 10.1056/NEJMoa1907423 BACKGROUND High-dose erythropoietin has been shown to have a neuroprotective effect in preclinical models of neonatal brain injury, and phase 2 trials have suggested possible efficacy; however, the benefits and safety of this therapy in extremely preterm...

ONLINE FIRST (FREE ACCESS)  Editorial ~ Joannidis M et al.- 10 myths about frusemide Conference reports and expert panel ~ Hawryluk G W J et al.- A management algorithm for patients with intracranial pressure monitoring: the Seattle   International Severe Traumatic Brain Injury Consensus Conference (SIBICC). Conference reports and expert panels. What's New in Intensive Care ~ SilversidesJet al.-&nbs...

ORIGINAL ARTICLE |FREE PREVIEW Soluble Urokinase Receptor and Acute Kidney Injury Salim S. Hayek, David E. Leaf, Ayman Samman Tahhan, et al N Engl J Med 2020; 382:416-426DOI: 10.1056/NEJMoa1911481 Abstract BACKGROUND Acute kidney injury is common, with a major effect on morbidity and health care utilization. Soluble urokinase plasminogen activator receptor (suPAR) is a signaling glycoprotein thought to be involved in the pathogenesis of kidney disease. W...

SCCM’s Top 5 of 2019 Concise Critical Appraisals Epinephrine Versus Norepinephrine...Early Sedation Using Dexmedetomidine...Antipsychotic Medications for Delirium...Moderate Therapeutic Hypothermia in...Effect of Low Versus Intermediate Tidal... Critical Connection Articles Wound Care CodingCentral Venous Access Procedures Peripheral Vasopressors: Friend or Foe? The Vasopressor Toolbox for Defending... 2019 Billing and Coding Changes for... iCritical Care P...

Preliminary Communication Caring for the Critically Ill PatientJanuary 17, 2020 Effect of Vitamin C, Hydrocortisone, and Thiamine vs Hydrocortisone Alone on Time Alive and Free of Vasopressor Support Among Patients With Septic Shock: The VITAMINS Randomized Clinical Trial Tomoko Fujii, Nora Luethi, Paul J. Young, et al JAMA. Published online January 17, 2020. doi:10.1001/jama.2019.22176 Abstract Importance  It is unclear whether vitamin C,...

Original Investigation |Caring for the Critically Ill Patient | January 17, 2020 Effect of Stress Ulcer Prophylaxis With Proton Pump Inhibitors vs Histamine-2 Receptor Blockers on In-Hospital Mortality Among ICU Patients Receiving Invasive Mechanical Ventilation: The PEPTIC Randomized Clinical Trial The PEPTIC Investigators for the Australian and New Zealand Intensive Care Society Clinical Trials Group, Alberta Health Services Critical Care Strategic Clinical Networ...

The Epidemiology of Sepsis in Chinese ICUs: A National Cross-Sectional Survey Xie Jianfeng, Wang Hongliang, Kang Yan, et al  Crit Care Med: December 5, 2019 doi: 10.1097/CCM.0000000000004155 Abstract Objectives: 目的 We performed a national cross-sectional survey to determine the epidemiologic characteristics of patients with sepsis in ICU in China. 通过进行全国性横断面调查，以明确中国ICU内脓毒症的流行病学特征。 Design: ...

Original Investigation January 21, 2020 Effect of Hydroxyethyl Starch vs Saline for Volume Replacement Therapy on Death or Postoperative Complications Among High-Risk Patients Undergoing Major Abdominal Surgery: The FLASH Randomized Clinical Trial Emmanuel Futier, Matthias Garot, Thomas Godet, et al JAMA. 2020;323(3):225-236. doi:10.1001/jama.2019.20833 Importance  It is not known if use of colloid solu...