Research Letter May 21, 2020 Postmortem Examination of Patients With COVID-19 Tina Schaller, Klaus Hirschbühl, Katrin Burkhardt, et al JAMA. 2020;323(24):2518-2520. doi:10.1001/jama.2020.8907 Approximately 15% of individuals affected by coronavirus disease 2019 (COVID-19) develop severe disease, and 5% to 6% are critically ill (respiratory failure and/or multiple organ dysfunction or failure).1,2 Severely ill and critically ill patients have a high mortal...

Mechanical Ventilation in COVID-19 There is no specific treatment for COVID-19 patients. For those who develop respiratory failure and are unable to oxygenate with non-invasive methods, critical care doctors are providing supportive therapy. Since the pandemic started, mechanical ventilation has routinely been employed to oxygenate seriously ill COVID-19 patients. Each hospital has developed its own criteria for identifying patients who require mechanical ven...

Original Investigation June 23/30, 2020 Effect of Intraoperative Dexamethasone on Major Complications and Mortality Among Infants Undergoing Cardiac Surgery: The DECISION Randomized Clinical Trial Vladimir Lomivorotov, Igor Kornilov, Vladimir Boboshko, et al JAMA. 2020;323(24):2485-2492. doi:10.1001/jama.2020.8133 Abstract Importance Corticosteroids are widely used in pediatric cardiac surgery to blunt systemic inflammatory response and to...

Research Letter June 15, 2020 Hospital-Wide SARS-CoV-2 Antibody Screening in 3056 Staff in a Tertiary Center in Belgium Deborah Steensels, Els Oris, Laura Coninx, et al JAMA. Published online June 15, 2020. doi:10.1001/jama.2020.11160 Belgium has a high burden of coronavirus disease 2019 (COVID-19), especially the region surrounding the Hospital East-Limburg, a tertiary care center.1 Infection prevention measures were instituted in the hospital ...

ARTICLES|ONLINE FIRST GM-CSF blockade with mavrilimumab in severe COVID-19 pneumonia and systemic hyperinflammation: a single-centre, prospective cohort study Giacomo De Luca, Giulio Cavalli, Corrado Campochiaro, et al Lancet Rheumatol Published:June 16, 2020 DOI:https://doi.org/10.1016/S2665-9913(20)30170-3 Summary Background Mortality in patients with COVID-19 pneumonia and systemic hyperinflammation is high. We aimed to examine whether mavrilimumab, a...

Research Letter | April 22, 2020 Alterations in Smell or Taste in Mildly Symptomatic Outpatients With SARS-CoV-2 Infection Giacomo Spinato, Cristoforo Fabbris,  Jerry Polesel, et al JAMA. 2020;323(20):2089-2090. doi:10.1001/jama.2020.6771 Since December 2019, a pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread globally.1 A spectrum of disease severity has been reported, with m...

Effect of Dexamethasone in Hospitalized Patients with COVID-19 – Preliminary Report RECOVERY Collaborative Group ABSTRACT Background: Coronavirus disease 2019 (COVID-19) is associated with diffuse lung damage. Corticosteroids may modulate immune-mediated lung injury and reducing progression to respiratory failure and death. Methods: The Randomised Evaluation of COVID-19 therapy (RECOVERY) trial is a randomized, controlled, open-label, adaptive, platform ...

Original Investigation June 3, 2020 Effect of Convalescent Plasma Therapy on Time to Clinical Improvement in Patients With Severe and Life-threatening COVID-19: A Randomized Clinical Trial Ling Li, Wei Zhang, Yu Hu, et al JAMA. Published online June 3, 2020. doi:10.1001/jama.2020.10044 Abstract Importance Convalescent plasma is a potential therapeutic option for patients with coronavirus disease 2019 (COVID-19), but further data from rando...

Original Investigation Caring for the Critically Ill Patient Association of Noninvasive Oxygenation Strategies With All-Cause Mortality in Adults With Acute Hypoxemic Respiratory Failure: A Systematic Review and Meta-analysis Bruno L. Ferreyro, Federico Angriman, Laveena Munshi, et al JAMA. Published online June 4, 2020. doi:10.1001/jama.2020.9524 Abstract Importance Treatment with noninvasive oxygenation strategies such as noninvasive ventilation and hi...

ARTICLES| VOLUME 395, ISSUE 10241, P1927-1936, JUNE 20, 2020 Effects of a high-dose 24-h infusion of tranexamic acid on death and thromboembolic events in patients with acute gastrointestinal bleeding (HALT-IT): an international randomised, double-blind, placebo-controlled trial The HALT-IT Trial Collaborators Lancet Published: June 20, 2020 DOI:https://doi.org/10.1016/S0140-6736(20)30848-5 Summary Background Tranexamic acid reduces surgical bleeding and...