Pessimism in providing critical care for elderly patients A recent study conducted in France investigated the association of age with long-term mortality after discharge from the ICU. Another subset of this discussion relates to the critically ill elderly patients who have higher mortality compared to younger patients as well as longer lengths of stay in the ICU prior to death.  There has been a great deal of discussion on how a disproportionate amount of health...

ORIGINAL ARTICLE C-Reactive Protein Testing to Guide Antibiotic Prescribing for COPD Exacerbations Christopher C. Butler, David Gillespie, Patrick White, et al N Engl J Med 2019; 381:111-120DOI: 10.1056/NEJMoa1803185 Abstract BACKGROUND 背景 Point-of-care testing of C-reactive protein (CRP) may be a way to reduce unnecessary use of antibiotics without harming patients who have acute exacerbations of chronic obstructive pulmonary disease (COPD). ...

ARTICLES|ONLINE FIRST Causes of severe pneumonia requiring hospital admission in children without HIV infection from Africa and Asia: the PERCH multi-country case-control study The Pneumonia Etiology Research for Child Health (PERCH) Study Group Lancet Published: June 27, 2019 DOI:https://doi.org/10.1016/S0140-6736(19)30721-4 Summary Background 背景 Pneumonia is the leading cause of death among children younger than 5 years. In this study, we estimated c...

ARTICLES|ONLINE FIRST The burden of Legionnaires' disease in New Zealand (LegiNZ): a national surveillance study Patricia C Priest, Sandy Slow, Stephen T Chambers, et al Lancet Published:June 10, 2019 DOI:https://doi.org/10.1016/S1473-3099(19)30113-6 Summary Background 背景 Legionnaires' disease is under-diagnosed because of inconsistent use of diagnostic tests and uncertainty about whom to test. We assessed the increase in case detection following large...

ARTICLES| VOLUME 19, ISSUE 6, P601-610, JUNE 01, 2019 Effect of carbapenem resistance on outcomes of bloodstream infection caused by Enterobacteriaceae in low-income and middle-income countries (PANORAMA): a multinational prospective cohort study Andrew J Stewardson, Kalisvar Marimuthu, Sharmila Sengupta, et al Lancet Infect Dis 2019; 19: 601-610 Summary Background 背景 Low-income and middle-income countries (LMICs) are under-represented i...

ONLINE FIRST THIS WEEK(FREE ACCESS) Review ~ Assoun S. - Molecular targeted therapy-related life-threatening toxicity in patients with malignancies. A systematic review of published cases Original ~ Haines K. J. - Key mechanisms by which post-ICU activities can improve in-ICU care: results of the international THRIVE collaboratives Imaging in Intensive Care Medicine ~ Salden R. L. T. N. - Camel shape in transpulmonary thermodilution monitoringWhat's new in intensive ca...

ARTICLES|ONLINE FIRST Association between urinary dickkopf-3, acute kidney injury, and subsequent loss of kidney function in patients undergoing cardiac surgery: an observational cohort study Stefan J Schunk, Alexander Zarbock, Melanie Meersch, et al Lancet Published:June 12, 2019 DOI:https://doi.org/10.1016/S0140-6736(19)30769-X Summary Background 背景 Cardiac surgery is associated with a high risk of postoperative acute kidney injury (AKI) and sub...

ARTICLES|ONLINE FIRST Chlorhexidine for meatal cleaning in reducing catheter-associated urinary tract infections: a multicentre stepped-wedge randomised controlled trial Oyebola Fasugba, Prof Allen C Cheng, Victoria Gregory, et al Lancet Infect Dis Published: April 12, 2019 DOI: https://doi.org/10.1016/S1473-3099(18)30736-9 Summary Background 背景 Evidence for the benefits of antiseptic meatal cleaning in reducing catheter-associated urinary tract i...

ICU Management & Practice, Volume 18 - Issue 2, 2018 Is pre-hospital coagulation management in trauma feasible? Coagulation management remains a formidable challenge in severely bleeding trauma patients. A strong rationale suggests starting treatment of trauma-induced coagulopathy in the pre-hospital phase.The burden of trauma is increasing worldwide, particularly in less well-resourced nations. There are an estimated 5 million deaths per year, more than TB...

Original Investigation April 29, 2019 Diagnostic Performance of Creatinine-Based Equations for Estimating Glomerular Filtration Rate in Adults 65 Years and Older Luciano da Silva Selistre, Dener L. Rech, Vandréa de Souza, et al JAMA Intern Med. Published online April 29, 2019. doi:10.1001/jamainternmed.2019.0223 Abstract Importance 背景 Estimating glomerular filtration rate (GFR) is useful in many clinical conditions. However, very few stu...