Research Article: Neutralization of interleukin-17A alleviates burn-induced intestinal barrier disruption via reducing pro-inflammatory cytokines in a mouse model How to cite: Song Y, Li Y, Xiao Y, Hu W, Wang X, Wang P, et al. Burns Trauma.2019; 7:37. 烧伤后肠粘膜屏障受损可能由多种机制共同作用，其中，局部及全身炎症反应的参与是肠粘膜屏障功能受损的重要因素。因此，如何在烧伤早期有效控制炎症的发生、发展，是保护肠粘膜，减少并发症，改善预后的重要因素。在多种炎症疾病模型中...

Research Article: Timely completion of multiple life-saving interventions for traumatic haemorrhagic shock: a retrospective cohort study 引用格式: Mitra B, Bade-Boon J, Fitzgerald MC, Beck B, Cameron PA. Timely completion of multiple life-saving interventions for traumatic haemorrhagic shock: a retrospective cohort study. Burns Trauma. 2019; 7:22. Abstract Background Early control of haemorrhage and optimisation of physiology are guiding principles of resuscit...

Liberal or Conservative Oxygen Therapy for Acute Respiratory Distress Syndrome Loic Barrot, Pierre Asfar, Frederic Mauny, et al N Engl J Med 2020; 382:999-1008DOI: 10.1056/NEJMoa1916431 Abstract BACKGROUND In patients with acute respiratory distress syndrome (ARDS), the National Heart, Lung, and Blood Institute ARDS Clinical Trials Network recommends a target partial pressure of arterial oxygen (Pao2) between 55 and 80 mm Hg. Prospective validation of this ...

Effect of Reduced Exposure to Vasopressors on 90-Day Mortality in Older Critically Ill Patients With Vasodilatory Hypotension: A Randomized Clinical Trial François Lamontagne, Alvin Richards-Belle, Karen Thomas, et al JAMA. 2020;323(10):938-949. doi:10.1001/jama.2020.0930 Abstract Importance Vasopressors are commonly administered to intensive care unit (ICU) patients to raise blood pressure. Balancing risks and benefits of vasopressors is a challenge, parti...

ARTICLES| VOLUME 8, ISSUE 3, P247-257, MARCH 01, 2020 Development and validation of parsimonious algorithms to classify acute respiratory distress syndrome phenotypes: a secondary analysis of randomised controlled trials Pratik Sinha, Kevin L Delucchi, Daniel F McAuley, et al Lancet Respir Med 2020; 8: 247-257 Summary Background Using latent class analysis (LCA) in five randomised controlled trial (RCT) cohorts, two distinct phenotypes of ...

ARTICLES| VOLUME 8, ISSUE 3, P258-266, MARCH 01, 2020 Sepsis-associated acute respiratory distress syndrome in individuals of European ancestry: a genome-wide association study Beatriz Guillen-Guio, Jose M Lorenzo-Salazar, Shwu-Fan Ma, et al Lancet 2020; 8: 258-266 Summary Background Acute respiratory distress syndrome (ARDS) is a lung inflammatory process caused mainly by sepsis. Most previous studies that identified genetic risks for ARD...

ORIGINAL ARTICLE Nonsedation or Light Sedation in Critically Ill, Mechanically Ventilated Patients Hanne T. Olsen, Helene K. Nedergaard, Thomas Strøm, et al Abstract BACKGROUND In critically ill, mechanically ventilated patients, daily interruption of sedation has been shown to reduce the time on ventilation and the length of stay in the intensive care unit (ICU). Data on whether a plan of no sedation, as compared with a plan of light sedation, has an effec...

ARTICLES|ONLINE FIRST Sepsis-associated acute respiratory distress syndrome in individuals of European ancestry: a genome-wide association study Beatriz Guillen-Guio, Jose M Lorenzo-Salazar, Shwu-Fan Ma, et al Lancet Respir Med Published:January 23, 2020 DOI:https://doi.org/10.1016/S2213-2600(19)30368-6 Summary Background Acute respiratory distress syndrome (ARDS) is a lung inflammatory process caused mainly by sepsis. Most previous studies that identifi...

Original Investigation Caring for the Critically Ill PatientFebruary 16, 2020 Association of Physician Orders for Life-Sustaining Treatment With ICU Admission Among Patients Hospitalized Near the End of Life Robert Y. Lee, Lyndia C. Brumback, Seelwan Sathitratanacheewin, et al JAMA. Published online February 16, 2020. doi:10.1001/jama.2019.22523 Abstract Importance Patients with chronic illness frequently use Physician Orders for Life-Sust...

Preliminary Communication Caring for the Critically Ill PatientFebruary 17, 2020 Effect of a Machine Learning–Derived Early Warning System for Intraoperative Hypotension vs Standard Care on Depth and Duration of Intraoperative Hypotension During Elective Noncardiac Surgery: The HYPE Randomized Clinical Trial Marije Wijnberge, Bart F. Geerts, Liselotte Hol, et al JAMA. Published online February 17, 2020. doi:10.1001/jama.2020.0592 Abstract Imp...