ORIGINAL ARTICLE Interferon Beta-1b and Lopinavir–Ritonavir for Middle East Respiratory Syndrome Yaseen M. Arabi, Ayed Y. Asiri, Abdullah M. Assiri, et al N Engl J Med October 7, 2020DOI: 10.1056/NEJMoa2015294 Abstract 摘要 BACKGROUND 背景 Whether combined treatment with recombinant interferon beta-1b and lopinavir–ritonavir reduces mortality among patients hospitalized with Middle East respiratory syndrome (MERS) is unclear. 重组beta-1b干扰素与克立芝...

ARTICLES|ONLINE FIRST Azithromycin in addition to standard of care versus standard of care alone in the treatment of patients admitted to the hospital with severe COVID-19 in Brazil (COALITION II): a randomised clinical trial Remo H M Furtado, Otavio Berwanger, Henrique A Fonseca, et al Lancet Published:September 04, 2020 DOI:https://doi.org/10.1016/S0140-6736(20)31862-6 Summary 摘要 Background 背景 The efficacy and safety of azithromycin in the treatmen...

ARTICLES|ONLINE FIRST Preoperative intravenous iron to treat anaemia before major abdominal surgery (PREVENTT): a randomised, double-blind, controlled trial Toby Richards, Ravishankar Rao Baikady, Ben Clevenger, et al Lancet Published:September 04, 2020 DOI:https://doi.org/10.1016/S0140-6736(20)31539-7 Summary 摘要 Background 背景 Preoperative anaemia affects a high proportion of patients undergoing major elective surgery and is associated with poor outc...

HealthManagement, Volume 20 - Issue 5, 2020 COVID-19 Antibody Testing – Why it Matters and Factors to Consider As we move into the next phase of the COVID-19 pandemic, there will be a need to test a broad strata of population, much more than what molecular tests can handle. The solution lies with serological tests. As the world continues the fight against COVID-19, healthcare executives are in an uncomfortable position – having to make critical decisions wit...

PulmCrit – Splitting ventilators to provide titrated support to a large group of patients March 15, 2020 by Josh Farkas COVID-19 might out-strip the number of mechanical ventilators available to us.  This has led to interest in using a single ventilator to support multiple patients.  This post will review the theory and evidence regarding this (with the admission that I don’t have experience with this).  basic principles Bedrock principle: ...

ARTICLES|ONLINE FIRST Defining persistent Staphylococcus aureus bacteraemia: secondary analysis of a prospective cohort study Richard Kuehl, Laura Morata, Christian Boeing, et al Lancet Infect Dis Published:August 04, 2020 DOI:https://doi.org/10.1016/S1473-3099(20)30447-3 Summary 摘要 Background 背景 Staphylococcus aureus persistent bacteraemia is only vaguely defined and the effect of different durations of bacteraemia on mortality is not well establish...

ICU Management & Practice, Volume 20 - Issue 2, 2020 Is COVID-19 the Black Swan? Nassim Taleb, in his book, "The Black Swan: The Impact of the Highly Improbable," describes the term Black Swan as a rare, unknown event, which with hindsight is rationalised. Taleb talks about the human tendency to always find simplistic explanations for unknown events, what he calls the Black Swan theory. Is COVID-19 a black swan? Introduction Physicians working with cr...

ARTICLES| VOLUME 396, ISSUE 10251, P603-611, AUGUST 29, 2020 Effects of a major deletion in the SARS-CoV-2 genome on the severity of infection and the inflammatory response: an observational cohort study Barnaby E Young, Siew-Wai Fong, Yi-Hao Chan, et al Lancet 2020; 396: 603-611 Summary 摘要 Background 背景 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants with a 382-nucleotide deletion (∆382) in the open reading frame 8 (ORF8) regio...

COVID-19-associated hyperinflammation and escalation of patient care: a retrospective longitudinal cohort study Jessica J Manson, Colin Crooks, Meena Naja, et al Lancet Rheumatol Published:August 21, 2020 DOI:https://doi.org/10.1016/S2665-9913(20)30275-7 Summary Background 背景 A subset of patients with severe COVID-19 develop a hyperinflammatory syndrome, which might contribute to morbidity and mortality. This study explores a specific phenotype of COVID-1...

ARTICLES| VOLUME 20, ISSUE 4, P425-434, APRIL 01, 2020 Radiological findings from 81 patients with COVID-19 pneumonia in Wuhan, China: a descriptive study Heshui Shi, Xiaoyu Han, Nanchuan Jiang, et al Lancet Infect Dis 2020; 20: 425-434 Summary 摘要 Background 背景 A cluster of patients with coronavirus disease 2019 (COVID-19) pneumonia caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were successively reported in Wuh...