Original Investigation November 17, 2020 Effect of an Emergency Department Care Bundle on 30-Day Hospital Discharge and Survival Among Elderly Patients With Acute Heart Failure: The ELISABETH Randomized Clinical Trial Yonathan Freund, Marine Cachanado, Quentin Delannoy, et al JAMA. 2020;324(19):1948-1956. doi:10.1001/jama.2020.19378 Abstract Importance Clinical guidelines for the early management of acute heart failure in the emergency dep...

ORIGINAL ARTICLE Repurposed Antiviral Drugs for Covid-19 — Interim WHO Solidarity Trial Results WHO Solidarity Trial Consortium N Engl J Med December 2, 2020DOI: 10.1056/NEJMoa2023184 Abstract BACKGROUND World Health Organization expert groups recommended mortality trials of four repurposed antiviral drugs — remdesivir, hydroxychloroquine, lopinavir, and interferon beta-1a — in patients hospitalized with coronavirus disease 2019 (Covid-19). METHODS ...

Cytokine elevation in severe and critical COVID-19: a rapid systematic review, meta-analysis, and comparison with other inflammatory syndromes Daniel E Leisman, Lukas Ronner, Rachel Pinotti, et al Lancet Respir Med Published:October 16, 2020 DOI:https://doi.org/10.1016/S2213-2600(20)30404-5 Summary The description of a so-called cytokine storm in patients with COVID-19 has prompted consideration of anti-cytokine therapies, particularly interleukin-6 antagonist...

ARTICLES|ONLINE FIRST Advanced reperfusion strategies for patients with out-of-hospital cardiac arrest and refractory ventricular fibrillation (ARREST): a phase 2, single centre, open-label, randomised controlled trial Demetris Yannopoulos, Jason Bartos, Ganesh Raveendran, et al Lancet Published:November 13, 2020 DOI:https://doi.org/10.1016/S0140-6736(20)32338-2 Summary Background Among patients with out-of-hospital cardiac arrest (OHCA) and ventricular ...

ORIGINAL ARTICLE SARS-CoV-2 Neutralizing Antibody LY-CoV555 in Outpatients with Covid-19 Peter Chen, Ajay Nirula, Barry Heller, et al N Engl J Med October 28, 2020DOI: 10.1056/NEJMoa2029849 Abstract BACKGROUND Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (Covid-19), which is most frequently mild yet can be severe and life-threatening. Virus-neutralizing monoclonal antibodies are predicted to reduce viral lo...

ORIGINAL ARTICLE A Randomized Trial of Convalescent Plasma in Covid-19 Severe Pneumonia Ventura A. Simonovich, Leandro D. Burgos Pratx, Paula Scibona, et al N Engl J Med November 24, 2020DOI: 10.1056/NEJMoa2031304 Abstract BACKGROUND Convalescent plasma is frequently administered to patients with Covid-19 and has been reported, largely on the basis of observational data, to improve clinical outcomes. Minimal data are available from adequately powered ran...

ONLINE FIRST THIS WEEK(FREE ACCESS)  What's New In Intensive Care ~ De Waele JJ et al. - Antimicrobial stewardship in ICUs during the COVID-19 pandemic: back to the 90sLetter ~ Schaefer MS et al. - Comparison of mechanical power estimations in mechanically ventilated patients with ARDS: a secondary data analysis from the EPVent studyEditorial ~ Shaw JA et al. - Five things every clinician should know about AI ...

Research Letter October 12, 2020 Excess Deaths From COVID-19 and Other Causes, March-July 2020 Steven H. Woolf, Derek A. Chapman, Roy T. Sabo, et al JAMA Published online October 12, 2020. doi:10.1001/jama.2020.19545 Previous studies of excess deaths (the gap between observed and expected deaths) during the coronavirus disease 2019 (COVID-19) pandemic found that publicly reported COVID-19 deaths underestimated the full death toll, which includes...

ARTICLES| VOLUME 20, ISSUE 10, P1151-1160, OCTOBER 01, 2020 Effectiveness of isolation, testing, contact tracing, and physical distancing on reducing transmission of SARS-CoV-2 in different settings: a mathematical modelling study Adam J Kucharski, Petra Klepac, Andrew J K Conlan, et al Lancet Infect Dis 2020; 20: 1151-1160 Summary 摘要 Background 背景 The isolation of symptomatic cases and tracing of contacts has been used as an early COVID-19 containme...

ICU Management & Practice, Volume 20 - Issue 1, 2020 Ultrasound in Times of COVID-19 The potential clinical utility of ultrasound modalities in the COVID-19 patient, the limitations, evidence base and governance over point of care ultrasound images during a pandemic and a discussion on whether the hype surrounding Lung Ultrasound (LUS) is justified. Introduction The use of ultrasound outside radiology has already become well established within many of...