Original Investigation September 8, 2020 Effect of Out-of-Hospital Tranexamic Acid vs Placebo on 6-Month Functional Neurologic Outcomes in Patients With Moderate or Severe Traumatic Brain Injury Susan E. Rowell, Eric N. Meier, Barbara McKnight, et al JAMA. 2020;324(10):961-974. doi:10.1001/jama.2020.8958 Abstract 摘要 Importance 背景 Traumatic brain injury (TBI) is the leading cause of death and disability due to trauma. Early administrati...

ORIGINAL ARTICLE FREE PREVIEW High-Flow Oxygen with Capping or Suctioning for Tracheostomy Decannulation Gonzalo Hernández Martínez, Maria-Luisa Rodriguez, Maria-Concepción Vaquero, et al N Engl J Med 2020; 383:1009-1017DOI: 10.1056/NEJMoa2010834 Abstract 摘要 BACKGROUND 背景 When patients with a tracheostomy tube reach a stage in their care at which decannulation appears to be possible, it is common practice to cap the tracheostomy tube for 24 hour...

Original Investigation Caring for the Critically Ill PatientSeptember 2, 2020 Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19: The REMAP-CAP COVID-19 Corticosteroid Domain Randomized Clinical Trial The Writing Committee for the REMAP-CAP Investigators JAMA. Published online September 2, 2020. doi:10.1001/jama.2020.17022 Abstract Importance Evidence regarding corticosteroid use for severe coronavirus...

Original Investigation Caring for the Critically Ill PatientSeptember 2, 2020 Effect of Dexamethasone on Days Alive and Ventilator-Free in Patients With Moderate or Severe Acute Respiratory Distress Syndrome and COVID-19: The CoDEX Randomized Clinical Trial Bruno M. Tomazini, Israel S. Maia, Alexandre B. Cavalcanti, et al JAMA. Published online September 2, 2020. doi:10.1001/jama.2020.17021 Abstract Importance Acute respiratory distress sy...

Research Letter July 20, 2020 Thrombosis in Hospitalized Patients With COVID-19 in a New York City Health System Seda Bilaloglu, Yin Aphinyanaphongs, Simon Jones, et al JAMA. 2020;324(8):799-801. doi:10.1001/jama.2020.13372 Patients with coronavirus disease 2019 (COVID-19) are at increased risk of thrombosis.1 However, studies have been limited in size, did not report all thrombotic events, and focused on patients with severe disease hospitalized in inten...

Original Investigation Caring for the Critically Ill PatientSeptember 2, 2020 Effect of Hydrocortisone on 21-Day Mortality or Respiratory Support Among Critically Ill Patients With COVID-19: A Randomized Clinical Trial Pierre-François Dequin, Nicholas Heming, Ferhat Meziani, et al JAMA. Published online September 2, 2020. doi:10.1001/jama.2020.16761 Abstract Importance Coronavirus disease 2019 (COVID-19) is associated with severe lung dama...

Original Investigation Caring for the Critically Ill PatientSeptember 2, 2020 Association Between Administration of Systemic Corticosteroids and Mortality Among Critically Ill Patients With COVID-19: A Meta-analysis The WHO Rapid Evidence Appraisal for COVID-19 Therapies (REACT) Working Group JAMA. Published online September 2, 2020. doi:10.1001/jama.2020.17023 Abstract 摘要 Importance 背景 Effective therapies for patients with corona...

ICU Management & Practice, Volume 20 - Issue 2, 2020 Keeping Best Practices in Critical Care During COVID-19 COVID-19 poses several challenges and has made it difficult to measure ICU performance. Sticking to evidence-based interventions can go a long way in improving outcomes and resource utilisation. How it Started Taking care of a COVID-19 patient comes with an initial surprise: there is no standard mindset to guide the physician’s work before ente...

Original Investigation September 1, 2020 Effect of Intraoperative Low Tidal Volume vs Conventional Tidal Volume on Postoperative Pulmonary Complications in Patients Undergoing Major Surgery: A Randomized Clinical Trial Dharshi Karalapillai, Laurence Weinberg, Philip Peyton, et al JAMA. 2020;324(9):848-858. doi:10.1001/jama.2020.12866 Abstract 摘要 Importance 背景 In patients who undergo mechanical ventilation during surgery, the ideal tida...

Research Physical distancing interventions and incidence of coronavirus disease 2019: natural experiment in 149 countries Nazrul Islam, Stephen J Sharp, Gerardo Chowell, et al  BMJ 2020; 370: m2743 doi: https://doi.org/10.1136/bmj.m2743 (Published 15 July 2020) Abstract Objective 目的 To evaluate the association between physical distancing interventions and incidence of coronavirus disease 2019 (covid-19) globally. 评价物理距离措施与全球新冠肺炎(COVID...