Original Investigation March 24, 2021 Effect of Intrawound Vancomycin Powder in Operatively Treated High-risk Tibia Fractures: A Randomized Clinical Trial The Major Extremity Trauma Research Consortium (METRC) JAMA Surg. 2021;156(5):e207259. doi:10.1001/jamasurg.2020.7259 Abstract Importance Despite the widespread use of systemic antibiotics to prevent infections in surgically treated patients with fracture, high rates of surgical site infection per...

Original Investigation January 15, 2021 Comparison of Saliva and Nasopharyngeal Swab Nucleic Acid Amplification Testing for Detection of SARS-CoV-2: A Systematic Review and Meta-analysis Guillaume Butler-Laporte, Alexander Lawandi, Ian Schiller, et al JAMA Intern Med. 2021;181(3):353-360. doi:10.1001/jamainternmed.2020.8876 Abstract Importance Nasopharyngeal swab nucleic acid amplification testing (NAAT) is the non...

Original Investigation December 10, 2020 Evaluation of Cloth Masks and Modified Procedure Masks as Personal Protective Equipment for the Public During the COVID-19 Pandemic Phillip W. Clapp, Emily E. Sickbert-Bennett, James M. Samet, et al JAMA Intern Med. 2021;181(4):463-469. doi:10.1001/jamainternmed.2020.8168 Abstract Importance During the coronavirus disease 2019 (COVID-19) pandemic, the general public has been advi...

ORIGINAL ARTICLE A Novel Circulating MicroRNA for the Detection of Acute Myocarditis Rafael Blanco-Domínguez, Raquel Sánchez-Díaz, Hortensia de la Fuente, et al N Engl J Med 2021; 384:2014-2027DOI: 10.1056/NEJMoa2003608 Abstract BACKGROUND The diagnosis of acute myocarditis typically requires either endomyocardial biopsy (which is invasive) or cardiovascular magnetic resonance imaging (which is not universally available). Additional approaches to diagnos...

ORIGINAL ARTICLE Antibiotic Therapy for 6 or 12 Weeks for Prosthetic Joint Infection Louis Bernard, Cédric Arvieux, Benoit Brunschweiler, et al N Engl J Med 2021; 384:1991-2001DOI: 10.1056/NEJMoa2020198 Abstract BACKGROUND The management of prosthetic joint infection usually consists of a combination of surgery and antimicrobial therapy. The appropriate duration of antimicrobial therapy for this indication remains unclear. METHODS We performed...

ONLINE FIRST (FREE ACCESS)  Dekeyser T. et al. ~Combined psychologist-physician post-death meeting as part of an integrated bereavement program for families Metnitz P.G.H. et al. ~ Evaluation and calibration of SAPS 3 in patients with COVID-19 admitted to intensive care units Du M. et al. ~Integrative omics provide biological and clinical insights into acute respiratory distress syndrome Dallmeier K. et al. ~ COVID-19 and the...

Original Investigation May 19, 2021 Triple vs Dual Inhaler Therapy and Asthma Outcomes in Moderate to Severe Asthma: A Systematic Review and Meta-analysis Lisa H. Y. Kim, Carol Saleh, Anna Whalen-Browne, et al JAMA. Published online May 19, 2021. doi:10.1001/jama.2021.7872 Abstract Importance The benefits and harms of adding long-acting muscarinic antagonists (LAMAs) to inhaled corticosteroids (ICS) and long-acting β2-agonists (LABAs) for ...

Closed incision negative pressure wound therapy versus standard dressings in obese women undergoing caesarean section: multicentre parallel group randomised controlled trial Brigid M Gillespie, Joan Webster, David Ellwood, et al BMJ 2021; 373 doi: https://doi.org/10.1136/bmj.n893 (Published 05 May 2021)Cite this as: BMJ 2021;373:n893 Abstract Objective To determine the effectiveness of closed incision negative pressure wound therapy (NPWT) compared with sta...

Research Hospital admission and mortality rates for non-covid diseases in Denmark during covid-19 pandemic: nationwide population based cohort study Jacob Bodilsen, Peter Brønnum Nielsen, Mette Søgaard, et al BMJ 2021; 373 doi: https://doi.org/10.1136/bmj.n1135 (Published 25 May 2021)Cite this as: BMJ 2021;373:n1135 Abstract Objective To determine the incidence of hospital admissions and associated mortality rates for non-covid medical conditions during ...

ORIGINAL ARTICLEFREE PREVIEW Hypothermia versus Normothermia after Out-of-Hospital Cardiac Arrest Josef Dankiewicz, Tobias Cronberg, Gisela Lilja, et al N Engl J Med 2021; 384:2283-2294DOI: 10.1056/NEJMoa2100591 Abstract BACKGROUND Targeted temperature management is recommended for patients after cardiac arrest, but the supporting evidence is of low certainty. METHODS In an open-label trial with blinded assessment of outcomes, we randomly assigned ...