ARTICLES| VOLUME 397, ISSUE 10283, P1447-1458, APRIL 17, 2021 Effect of infusion set replacement intervals on catheter-related bloodstream infections (RSVP): a randomised, controlled, equivalence (central venous access device)–non-inferiority (peripheral arterial catheter) trial Claire M Rickard, Nicole M Marsh, Emily N Larsen, et al Lancet 2021; 397: 1447-1458 DOI:https://doi.org/10.1016/S0140-6736(21)00351-2 Summary Background The opt...

Original Investigation Caring for the Critically Ill PatientMarch 23/30, 2021 Ventilator Weaning and Discontinuation Practices for Critically Ill Patients Karen E. A. Burns, Leena Rizvi, Deborah J. Cook, et al JAMA. 2021;325(12):1173-1184. doi:10.1001/jama.2021.2384 Abstract Importance 背景 Although most critically ill patients receive invasive mechanical ventilation (IMV), few studies have characterized ...

ORIGINAL ARTICLE Hypothermic Machine Perfusion in Liver Transplantation — A Randomized Trial Rianne van Rijn, Ivo J. Schurink, Yvonne de Vries, et al N Engl J Med 2021; 384:1391-1401DOI: 10.1056/NEJMoa2031532 Abstract BACKGROUND Transplantation of livers obtained from donors after circulatory death is associated with an increased risk of nonanastomotic biliary strictures. Hypothermic oxygenated machine perfusion of livers may reduce the incidence of bili...

Original Investigation Caring for the Critically Ill PatientMarch 23/30, 2021 Intubation Practices and Adverse Peri-intubation Events in Critically Ill Patients From 29 Countries Vincenzo Russotto, Sheila Nainan Myatra, John G. Laffey, et al JAMA. 2021;325(12):1164-1172. doi:10.1001/jama.2021.1727 Abstract Importance 背景 Tracheal intubation is one of the most commonly performed and high-risk intervention...

Original Investigation March 4, 2021 Effect of Ivermectin on Time to Resolution of Symptoms Among Adults With Mild COVID-19: A Randomized Clinical Trial Eduardo López-Medina, Pío López, Isabel C. Hurtado, et al JAMA. Published online March 4, 2021. doi:10.1001/jama.2021.3071 Abstract Importance Ivermectin is widely prescribed as a potential treatment for COVID-19 despite uncertainty about its clinical benefit. Objective To determine ...

Research Excess mortality in Wuhan city and other parts of China during the three months of the covid-19 outbreak: findings from nationwide mortality registries Jiangmei Liu, Lan Zhang,  Yaqiong Yan, et al BMJ 2021; 372: n415 doi: https://doi.org/10.1136/bmj.n415 (Published 24 February 2021) Abstract Objective To assess excess all cause and cause specific mortality during the three months (1 January to 31 March 2020) of the coronavirus disease 2019 (covi...

Research Letter February 17, 2021 Discriminant Accuracy of the SOFA Score for Determining the Probable Mortality of Patients With COVID-19 Pneumonia Requiring Mechanical Ventilation Robert A. Raschke, Sumit Agarwal, Pooja Rangan, et al JAMA. Published online February 17, 2021. doi:10.1001/jama.2021.1545 The coronavirus disease 2019 (COVID-19) pandemic has raised concern regarding the capacity to provide care for a surge of critically ill patient...

ARTICLES|ONLINE FIRST Azithromycin for community treatment of suspected COVID-19 in people at increased risk of an adverse clinical course in the UK (PRINCIPLE): a randomised, controlled, open-label, adaptive platform trial PRINCIPLE Trial Collaborative Group Lancet Published:March 04, 2021 DOI:https://doi.org/10.1016/S0140-6736(21)00461-X Summary Background Azithromycin, an antibiotic with potential antiviral and anti-inflammatory properties, has b...

HOW TO VENTILATE COVID-19 PATIENTS? TWINSTREAM® ICU WITH P-BLV® (PULSATILE BILEVEL VENTILATION) The Austrian critical care ventilator TwinStream® ICU was designed with the explicit purpose of saving critically respiratory-distressed patients. In particular those patients with severe lung diseases (e.g. ARDS) who can no longer be supported with conventional ventilation. Its unique p-BLV® mode has become an established value in many Intensive Care Units in Austrian...

ARTICLES|ONLINE FIRST Identification and validation of clinical phenotypes with prognostic implications in patients admitted to hospital with COVID-19: a multicentre cohort study Belén Gutiérrez-Gutiérrez, María Dolores del Toro, Alberto M Borobia, et al Lancet Infect Dis Published:February 23, 2021 DOI:https://doi.org/10.1016/S1473-3099(21)00019-0 Summary Background The clinical presentation of COVID-19 in patients admitted to hospital is heterogen...