Original Investigation  Helicobacter pylori Screening After Acute Myocardial Infarction: The Cluster Randomized Crossover HELP-MI SWEDEHEART Trial Robin Hofmann, Stefan James, Martin O. Sundqvist, et al JAMA 2025;334;(13):1160-1169. doi:10.1001/jama.2025.15047 Key Points Question  Does routine Helicobacter pylori screening with urea breath test of patients with myocardial infarction reduce upper gastrointestinal bleeding events? ...

Original Investigation  Critical Care Medicine Cost-Effectiveness of In-Bed Cycling and Routine Physiotherapy for Patients Receiving Mechanical Ventilation Jean-Eric Tarride, Gord Blackhouse, Bram Rochwerg, et al JAMA Netw Open 2025;8;(9):e2529399. doi:10.1001/jamanetworkopen.2025.29399 Key Points Question  What is the cost-effectiveness of in-bed cycling plus usual physiotherapy compared with usual physi...

ONLINE FIRST (FREE ACCESS) LATEST ARTICLES Original Heterogeneity in the response to a high vs low mean arterial pressure target in patients with septic shock: a post hoc analysis of a randomized controlled trialPirracchio, R., Fong, N. & Legrand, M. OPEN ACCESS ~ Original Monocyte HLA-DR expression in septic shock patients: insights from a 20-year real-world cohort of 1023 casesMonneret, G., Lafon, T., Gossez, M. et al. Acute respiratory distre...

Original Investigation  Critical Care Medicine Early Blood Pressure Targets in Acute Spinal Cord Injury: A Randomized Clinical Trial Ruba Sajdeya, N. David Yanez, Michael Kampp, et al JAMA Netw Open 2025;8;(9):e2525364. doi:10.1001/jamanetworkopen.2025.25364 Key Points Question  Compared with conventional blood pressure, does early blood pressure augmentation improve long-term neurologic outcomes in acute spinal cord injury? Findings&nb...

Original Investigation  Neurology Acute Surgery vs Conservative Treatment for Traumatic Acute Subdural Hematoma Thomas A. Van Essen, John K. Yue, Jason Barber, et al JAMA Netw Open 2025;8;(10):e2535200. doi:10.1001/jamanetworkopen.2025.35200 Key Points Question  Among US trauma centers, is a treatment strategy for traumatic acute subdural hematoma (ASDH) preferring acute surgery superior to one preferring conservative treatment? Finding...

Articles Acute pulmonary embolism in children and adolescents in the USA (2016 and 2019): a nationwide retrospective cohort study Simon Wolf, Luca Valerio, Nils Kucher, et al Lancet Respir Med 2025; 13: 393-402 https://doi.org/10.1016/S2213-2600(24)00412-0 Summary Background Epidemiological data on acute pulmonary embolism among children and adolescents are sparse and only date back to the 2000s. We aimed to establish annual estimates and ag...

Consensus Statement  Critical Care Medicine Rationale and Methodological Approach Underlying the Development of the Sequential Organ Failure Assessment (SOFA)–2 Score: A Consensus Statement Rui Moreno, Andrew Rhodes, Otavio Ranzani, et al JAMA Netw Open 2025;8;(10):e2545040. doi:10.1001/jamanetworkopen.2025.45040 Key Points Question  Can an update to the Sequential Organ Failure Assessment (SOFA) score that reflects current clinical practi...

Original Investigation  Caring for the Critically Ill Patient Development and Validation of the Sequential Organ Failure Assessment (SOFA)-2 Score Otavio T. Ranzani, Mervyn Singer, Jorge I. F. Salluh, et al JAMA Published Online: October 29, 2025 doi: 10.1001/jama.2025.20516 Key Points Question  Does an updated Sequential Organ Failure Assessment (SOFA)-2 score describe organ dysfunction in critically ill patients and its association wi...

Original Investigation  Caring for the Critically Ill Patient Sodium Bicarbonate for Severe Metabolic Acidemia and Acute Kidney Injury: The BICARICU-2 Randomized Clinical Trial Boris Jung, Mathieu Jabaudon, Audrey De Jong, et al JAMA Published Online: October 29, 2025 doi: 10.1001/jama.2025.20231 Key Points Question  For patients with severe metabolic acidosis and moderate to severe acute kidney injury, does sodium bicarbonate infusion ...

Original Investigation  Caring for the Critically Ill Patient Personalized Hemodynamic Resuscitation Targeting Capillary Refill Time in Early Septic Shock: The ANDROMEDA-SHOCK-2 Randomized Clinical Trial The ANDROMEDA-SHOCK-2 Investigators for the ANDROMEDA Research Network, Spanish Society of Anesthesiology, Reanimation and Pain Therapy (SEDAR), and Latin American Intensive Care Network (LIVEN) JAMA Published Online: October 29, 2025 doi: 10.1001/jama...