ORIGINAL ARTICLE Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine Lindsey R. Baden, Hana M. El Sahly, Brandon Essink, et al N Engl J Med 2021; 384:403-416DOI: 10.1056/NEJMoa2035389 Abstract BACKGROUND Vaccines are needed to prevent coronavirus disease 2019 (Covid-19) and to protect persons who are at high risk for complications. The mRNA-1273 vaccine is a lipid nanoparticle–encapsulated mRNA-based vaccine that encodes the prefusion stabilized full...

CORRESPONDENCE Duration of Culturable SARS-CoV-2 in Hospitalized Patients with Covid-19 Min-Chul Kim, Chunguang Cui, Kyeong-Ryeol Shin, et al N Engl J Med January 27, 2021DOI: 10.1056/NEJMc2027040 TO THE EDITOR: The duration of transmissibility of coronavirus disease 2019 (Covid-19) and the associated level of contagion have been uncertain. We cultured severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in serial respiratory samples obtained from h...

Nebulised heparin for patients with or at risk of acute respiratory distress syndrome: a multicentre, randomised, double-blind, placebo-controlled phase 3 trial Barry Dixon, Roger J Smith, Duncan J Campbell, et al Lancet Respir Med Published:January 22, 2021 DOI:https://doi.org/10.1016/S2213-2600(20)30470-7 Summary Background Mechanical ventilation in intensive care for 48 h or longer is associated with the acute respiratory distress syndrome (ARDS), which ...

Global variation in postoperative mortality and complications after cancer surgery: a multicentre, prospective cohort study in 82 countries GlobalSurg Collaborative and National Institute for Health Research Global Health Research Unit on Global Surgery Lancet 2021; 397: 387–97 Summary Background 80% of individuals with cancer will require a surgical procedure, yet little comparative data exist on early outcomes in low-income and middle-income countries (LM...

Original Contribution October 8, 2003 Safety of Patients Isolated for Infection Control Henry Thomas Stelfox, David W. Bates, Donald A. Redelmeier, et al JAMA 2003;290(14):1899-1905. doi:10.1001/jama.290.14.1899 Abstract Context 背景 Hospital infection control policies that use patient isolation prevent nosocomial transmission of infectious diseases, but may inadvertently lead to patient neglect and errors. 医院的感染控制措施要求对患者进行隔离以...

Oxygen Therapy in Acute Care Medicine Oxygen therapy is a commonly used strategy in modern medicine. In most situations with declining oxygen saturations, clinicians are quick to use this technique. While effective in the setting of hypoxia, there are, however, some circumstances in which excess oxygen is indiscriminately administered for extended periods. In healthcare, there has been a significant shift from the concept of "more is better" to "less is more." There...

CORRESPONDENCE Racial Bias in Pulse Oximetry Measurement Michael W. Sjoding, Robert P. Dickson, Theodore J. Iwashyna, et al N Engl J Med 2020; 383:2477-2478DOI: 10.1056/NEJMc2029240 TO THE EDITOR: Oxygen is among the most frequently administered medical therapies, with a level that is commonly adjusted according to the reading on a pulse oximeter that measures patients’ oxygen saturation. Questions about pulse oximeter technology have been raised, given its...

ORIGINAL ARTICLE Tocilizumab in Patients Hospitalized with Covid-19 Pneumonia Carlos Salama, Jian Han, Linda Yau, et al N Engl J Med 2021; 384:20-30DOI: 10.1056/NEJMoa2030340 Abstract BACKGROUND Coronavirus disease 2019 (Covid-19) pneumonia is often associated with hyperinflammation. Despite the disproportionate incidence of Covid-19 among underserved and racial and ethnic minority populations, the safety and efficacy of the anti–interleukin-6 recep...

Research Letter December 14, 2020 Readmission and Death After Initial Hospital Discharge Among Patients With COVID-19 in a Large Multihospital System John P. Donnelly, Xiao Qing Wang, Theodore J. Iwashyna, et al JAMA. Published online December 14, 2020. doi:10.1001/jama.2020.21465 Although more patients are surviving severe coronavirus disease 2019 (COVID-19), there are limited data on outcomes after initial hospitalization. We therefore measure...

Research Christmas 2020: The Citadel Nonsensus in the treatment of proximal humerus fractures: uncontrolled, blinded, comparative behavioural analysis between Homo chirurgicus accidentus and Macaca sylvanus Sam Razaeian, Birgitt Wiese, Dafang Zhang, et al BMJ 2020; 371: m4429 doi: https://doi.org/10.1136/bmj.m4429 (Published 14 December 2020)  Abstract Objective To investigate the inter-rater reliability of Barbary macaques compared with an expert g...