Original Investigation May 11, 2021 Effect of Antimicrobial Therapy on Respiratory Hospitalization or Death in Adults With Idiopathic Pulmonary Fibrosis: The CleanUP-IPF Randomized Clinical Trial Fernando J. Martinez, Eric Yow, Kevin R. Flaherty, et al JAMA. 2021;325(18):1841-1851. doi:10.1001/jama.2021.4956 Abstract Importance Alteration in lung microbes is associated with disease progression in idiopathic pulmonary fibrosis. Objective...

Research Prophylaxis against covid-19: living systematic review and network meta-analysis Jessica J Bartoszko, Reed A C Siemieniuk,  Elena Kum, et al BMJ 2021; 373 doi: https://doi.org/10.1136/bmj.n949 (Published 26 April 2021)Cite this as: BMJ 2021;373:n949 Abstract Objective To determine and compare the effects of drug prophylaxis on SARS-CoV-2 infection and covid-19. Design Living systematic review and network meta-analysis. Data sources W...

Original Investigation May 25, 2021 Effect of Continuous Infusion of Hypertonic Saline vs Standard Care on 6-Month Neurological Outcomes in Patients With Traumatic Brain Injury: The COBI Randomized Clinical Trial Antoine Roquilly, Jean Denis Moyer, Olivier Huet, et al JAMA. 2021;325(20):2056-2066. doi:10.1001/jama.2021.5561 Abstract Importance Fluid therapy is an important component of care for patients with traumatic brain injury, but whe...

Research Suicide and self-harm in adult survivors of critical illness: population based cohort study Shannon M Fernando, Danial Qureshi, Manish M Sood, et al BMJ 2021; 373: n973 doi: https://doi.org/10.1136/bmj.n973 Abstract Objective To analyse the association between survival from critical illness and suicide or self-harm after hospital discharge. Design Population based cohort study using linked and validated provincial databases. Setting ...

Original Investigation May 26, 2021 Effect of 2 Inactivated SARS-CoV-2 Vaccines on Symptomatic COVID-19 Infection in Adults: A Randomized Clinical Trial Nawal Al Kaabi, Yuntao Zhang, Shengli Xia, et al JAMA. Published online May 26, 2021. doi:10.1001/jama.2021.8565 Abstract Importance Although effective vaccines against COVID-19 have been developed, additional vaccines are still needed. Objective To evaluate the efficacy and adverse ...

ORIGINAL ARTICLE Dexamethasone and Surgical-Site Infection Tomás B. Corcoran, Paul S. Myles, Andrew B. Forbes, et al N Engl J Med 2021; 384:1731-1741DOI: 10.1056/NEJMoa2028982 Abstract BACKGROUND The glucocorticoid dexamethasone prevents nausea and vomiting after surgery, but there is concern that it may increase the risk of surgical-site infection. METHODS In this pragmatic, international, noninferiority trial, we randomly assigned 8880 adult pati...

Original Investigation May 4, 2021 Effect of Half-Dose vs Stable-Dose Conventional Synthetic Disease-Modifying Antirheumatic Drugs on Disease Flares in Patients With Rheumatoid Arthritis in Remission: The ARCTIC REWIND Randomized Clinical Trial Siri Lillegraven, Nina Paulshus Sundlisæter, Anna-Birgitte Aga, et al JAMA. 2021;325(17):1755-1764. doi:10.1001/jama.2021.4542 Abstract Importance Sustained remission has become an achievable goal f...

ORIGINAL ARTICLE Tranexamic Acid for the Prevention of Blood Loss after Cesarean Delivery Loïc Sentilhes, Marie V. Sénat, Maëla Le Lous, et al N Engl J Med 2021; 384:1623-1634DOI: 10.1056/NEJMoa2028788 Abstract BACKGROUND Prophylactic administration of tranexamic acid has been associated with reduced postpartum blood loss after cesarean delivery in several small trials, but evidence of its benefit in this clinical context remains inconclusive. METHODS...

ORIGINAL ARTICLE Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19 The REMAP-CAP Investigators N Engl J Med 2021; 384:1491-1502DOI: 10.1056/NEJMoa2100433 Abstract BACKGROUND The efficacy of interleukin-6 receptor antagonists in critically ill patients with coronavirus disease 2019 (Covid-19) is unclear. METHODS We evaluated tocilizumab and sarilumab in an ongoing international, multifactorial, adaptive platform trial. Adul...

Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial RECOVERY Collaborative Group Lancet Published:May 14, 2021 DOI:https://doi.org/10.1016/S0140-6736(21)00897-7 Summary Background Many patients with COVID-19 have been treated with plasma containing anti-SARS-CoV-2 antibodies. We aimed to evaluate the safety and efficacy of convalescent plasma therapy in patients admitted to ho...