Closed incision negative pressure wound therapy versus standard dressings in obese women undergoing caesarean section: multicentre parallel group randomised controlled trial Brigid M Gillespie, Joan Webster, David Ellwood, et al BMJ 2021; 373 doi: https://doi.org/10.1136/bmj.n893 (Published 05 May 2021)Cite this as: BMJ 2021;373:n893 Abstract Objective To determine the effectiveness of closed incision negative pressure wound therapy (NPWT) compared with sta...

Research Hospital admission and mortality rates for non-covid diseases in Denmark during covid-19 pandemic: nationwide population based cohort study Jacob Bodilsen, Peter Brønnum Nielsen, Mette Søgaard, et al BMJ 2021; 373 doi: https://doi.org/10.1136/bmj.n1135 (Published 25 May 2021)Cite this as: BMJ 2021;373:n1135 Abstract Objective To determine the incidence of hospital admissions and associated mortality rates for non-covid medical conditions during ...

ORIGINAL ARTICLEFREE PREVIEW Hypothermia versus Normothermia after Out-of-Hospital Cardiac Arrest Josef Dankiewicz, Tobias Cronberg, Gisela Lilja, et al N Engl J Med 2021; 384:2283-2294DOI: 10.1056/NEJMoa2100591 Abstract BACKGROUND Targeted temperature management is recommended for patients after cardiac arrest, but the supporting evidence is of low certainty. METHODS In an open-label trial with blinded assessment of outcomes, we randomly assigned ...

ONLINE FIRST THIS WEEK(FREE ACCESS) Tanios M. et al. ~Fentanyl- and midazolam-induced coma each influence days of mechanical ventilation and 28-day mortality Kalbhenn J. et al. ~ “Do no further harm” – Why shall we sedate unresponsive patients? Vaara S.T. et al. ~Restrictive fluid management versus usual care in acute kidney injury (REVERSE-AKI): a pilot randomized controlled feasibility trial Patel B.V. et al. ~ Natural history, trajectory...

ARTICLES| VOLUME 397, ISSUE 10288, P1885-1894, MAY 22, 2021 Patient care and clinical outcomes for patients with COVID-19 infection admitted to African high-care or intensive care units (ACCCOS): a multicentre, prospective, observational cohort study The African COVID-19 Critical Care Outcomes Study (ACCCOS) Investigators Lancet 2021; 397: 1885-1894 DOI:https://doi.org/10.1016/S0140-6736(21)00441-4 Summary Background There have been ins...

CORRESPONDENCE PF4 Immunoassays in Vaccine-Induced Thrombotic Thrombocytopenia N Engl J Med May 19, 2021DOI: 10.1056/NEJMc2106383 TO THE EDITOR: In a recent study, Greinacher et al.1 reported thrombotic complications, mostly cerebral vein thrombosis, associated with thrombocytopenia in 11 patients after they had been vaccinated with ChAdOx1 nCoV-19 (AstraZeneca). Although none of these patients had received heparin, the authors detected high titers of anti–pla...

ARTICLES|ONLINE FIRST Effects of nurse-to-patient ratio legislation on nurse staffing and patient mortality, readmissions, and length of stay: a prospective study in a panel of hospitals Matthew D McHugh, Linda H Aiken, Douglas M Sloane, et al Lancet Published: May 11, 2021 DOI:https://doi.org/10.1016/S0140-6736(21)00768-6 Summary Background Substantial evidence indicates that patient outcomes are more favourable in hospitals with better nurse staffin...

ARTICLES| VOLUME 397, ISSUE 10291, P2253-2263, JUNE 12, 2021 Therapeutic versus prophylactic anticoagulation for patients admitted to hospital with COVID-19 and elevated D-dimer concentration (ACTION): an open-label, multicentre, randomised, controlled trial Renato D Lopes, Pedro Gabriel Melo de Barros e Silva, Remo H M Furtado, et al Lancet 2021; 397: 2253-2263 DOI:https://doi.org/10.1016/S0140-6736(21)01203-4 Summary Background C...

Research Letter May 6, 2021 Asymptomatic and Symptomatic SARS-CoV-2 Infections After BNT162b2 Vaccination in a Routinely Screened Workforce Li Tang, Diego R. Hijano, Aditya H. Gaur, et al JAMA. Published online May 6, 2021. doi:10.1001/jama.2021.6564 A 2-dose regimen of the BNT162b2 vaccine (Pfizer-BioNTech) against SARS-CoV-2 was authorized in December 2020 based on reported 94.8% efficacy.1 Although an association between vaccination and a red...

Original Investigation May 11, 2021 Effect of a Digital Intervention on Depressive Symptoms in Patients With Comorbid Hypertension or Diabetes in Brazil and Peru: Two Randomized Clinical Trials Ricardo Araya, Paulo Rossi Menezes, Heloísa Garcia Claro, et al JAMA. 2021;325(18):1852-1862. doi:10.1001/jama.2021.4348 Abstract Importance  Depression is a leading contributor to disease burden globally. Digital mental health interventions ...