ORIGINAL ARTICLE Tocilizumab in Hospitalized Patients with Severe Covid-19 Pneumonia Ivan O. Rosas, Norbert Bräu, Michael Waters, et al N Engl J Med February 25, 2021DOI: 10.1056/NEJMoa2028700 Abstract BACKGROUND Coronavirus disease 2019 (Covid-19) is associated with immune dysregulation and hyperinflammation, including elevated interleukin-6 levels. The use of tocilizumab, a monoclonal antibody against the interleukin-6 receptor, has resulted in better ...

2020年引用最多论文  Understanding the disease ~ Zang H. et al. - Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target Letter ~ Ruan Q. et al. ~Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China Guidelines ~ Alhazzani W. et al. - Surviving Sepsis Campaign: guidelines on the management of cr...

ONLINE FIRST THIS WEEK(FREE ACCESS)  Original ~ Buetti N. et al. - COVID-19 increased the risk of ICU-acquired bloodstream infections: a case–cohort study from the multicentric OUTCOMEREA networkEditorial ~ Dale C.M. et al. - Leaving a mark: pressure injury research in the intensive care unitLetter ~ Proudfoot A.G. et al. - Rapid establishment of a COVID-19 critical care unit in a convention centre: the Nightingale Hospital London experienceCorrespondence ~ Meduri...

Research Effect of tocilizumab on clinical outcomes at 15 days in patients with severe or critical coronavirus disease 2019: randomised controlled trial Viviane C Veiga, João A G G Prats, Danielle L C Farias, et al BMJ 2021; 372: n84 doi: https://doi.org/10.1136/bmj.n84 Abstract Objective To determine whether tocilizumab improves clinical outcomes for patients with severe or critical coronavirus disease 2019 (covid-19). Design Randomised, open labe...

Original Investigation Caring for the Critically Ill PatientFebruary 23, 2021 Effect of Vitamin C, Thiamine, and Hydrocortisone on Ventilator- and Vasopressor-Free Days in Patients With Sepsis: The VICTAS Randomized Clinical Trial Jonathan E. Sevransky, Richard E. Rothman, David N. Hager, et al JAMA. 2021;325(8):742-750. doi:10.1001/jama.2020.24505 Abstract Importance Sepsis is a common syndrome with substantial morbidity and mortality. A ...

Original Investigation January 19, 2021 Effect of Discontinuing vs Continuing Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers on Days Alive and Out of the Hospital in Patients Admitted With COVID-19: A Randomized Clinical Trial Renato D. Lopes, Ariane V. S. Macedo, Pedro G. M. de Barros E Silva, et al JAMA. 2021;325(3):254-264. doi:10.1001/jama.2020.25864 Abstract Importance It is unknown whether angiotensin-c...

Azithromycin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial  RECOVERY Collaborative Group Lancet 2021; 397: 605–12  https://doi.org/10.1016/ S0140-6736(21)00149-5  Summary  Background Azithromycin has been proposed as a treatment for COVID-19 on the basis of its immunomodulatory actions. We aimed to evaluate the safety and efficacy of azithromycin in patients admitted to hospital with COVID...

Original Investigation January 19, 2021 Effect of Endovascular Treatment Alone vs Intravenous Alteplase Plus Endovascular Treatment on Functional Independence in Patients With Acute Ischemic Stroke: The DEVT Randomized Clinical Trial Wenjie Zi, Zhongming Qiu, Fengli Li, et al JAMA. 2021;325(3):234-243. doi:10.1001/jama.2020.23523 Abstract Importance For patients with large vessel occlusion strokes, it is unknown whether endovascular treatm...

Original Investigation Association of Intravenous Immunoglobulins Plus Methylprednisolone vs Immunoglobulins Alone With Course of Fever in Multisystem Inflammatory Syndrome in Children Naïm Ouldali, MD, Julie Toubiana, Denise Antona, et al JAMA. Published online February 1, 2021. doi:10.1001/jama.2021.0694 Abstract Importance Multisystem inflammatory syndrome in children (MIS-C) is the most severe pediatric disease associated with severe acute respirator...

Original Investigation January 19, 2021 Effect of Mechanical Thrombectomy Without vs With Intravenous Thrombolysis on Functional Outcome Among Patients With Acute Ischemic Stroke: The SKIP Randomized Clinical Trial Kentaro Suzuki, Yuji Matsumaru, Masataka Takeuchi, et al JAMA. 2021;325(3):244-253. doi:10.1001/jama.2020.23522 Abstract Importance Whether intravenous thrombolysis is needed in combination with mechanical thrombectomy in patien...