Original Investigation June 1, 2021 Effect of Reduced-Dose vs High-Dose Glucocorticoids Added to Rituximab on Remission Induction in ANCA-Associated Vasculitis: A Randomized Clinical Trial Shunsuke Furuta, Daiki Nakagomi, Yoshihisa Kobayashi, et al JAMA. 2021;325(21):2178-2187. doi:10.1001/jama.2021.6615 Abstract Importance The current standard induction therapy for antineutrophil cytoplasm antibody (ANCA...

Original Investigation January 13, 2021 Postdischarge Virtual Visits for Low-risk Surgeries: A Randomized Noninferiority Clinical Trial Kristen Harkey, Nicole Kaiser, Jing Zhao, et al JAMA Surg. 2021;156(3):221-228. doi:10.1001/jamasurg.2020.6265 Abstract Importance Postdischarge video-based virtual visits are a growing aspect of surgical care and have dramatically increased in the setting of the coronavirus disease 2019 (COVID-19) pandemic. Obje...

Original Investigation February 17, 2021 Association of Cryoprecipitate Use With Survival After Major Trauma in Children Receiving Massive Transfusion Maria A. Tama, Melvin E. Stone Jr, Stephen M. Blumberg, et al JAMA Surg. 2021;156(5):453-460. doi:10.1001/jamasurg.2020.7199 Abstract Importance Although most massive transfusion protocols incorporate cryoprecipitate in the treatment of hemorrhaging injured patients, minimal data exist on its use in c...

Original Investigation March 17, 2021 Association Between Anesthesiologist Volume and Short-term Outcomes in Complex Gastrointestinal Cancer Surgery Julie Hallet, Angela Jerath, Alexis F. Turgeon, MD, et al JAMA Surg. 2021;156(5):479-487. doi:10.1001/jamasurg.2021.0135 Abstract Importance Intraoperative anesthesiology care is crucial to high-quality surgical care. The clinical expertise and experience of anesthesiologists may decrease the risk of ad...

Original Investigation March 24, 2021 Effect of Intrawound Vancomycin Powder in Operatively Treated High-risk Tibia Fractures: A Randomized Clinical Trial The Major Extremity Trauma Research Consortium (METRC) JAMA Surg. 2021;156(5):e207259. doi:10.1001/jamasurg.2020.7259 Abstract Importance Despite the widespread use of systemic antibiotics to prevent infections in surgically treated patients with fracture, high rates of surgical site infection per...

Original Investigation January 15, 2021 Comparison of Saliva and Nasopharyngeal Swab Nucleic Acid Amplification Testing for Detection of SARS-CoV-2: A Systematic Review and Meta-analysis Guillaume Butler-Laporte, Alexander Lawandi, Ian Schiller, et al JAMA Intern Med. 2021;181(3):353-360. doi:10.1001/jamainternmed.2020.8876 Abstract Importance Nasopharyngeal swab nucleic acid amplification testing (NAAT) is the non...

Original Investigation December 10, 2020 Evaluation of Cloth Masks and Modified Procedure Masks as Personal Protective Equipment for the Public During the COVID-19 Pandemic Phillip W. Clapp, Emily E. Sickbert-Bennett, James M. Samet, et al JAMA Intern Med. 2021;181(4):463-469. doi:10.1001/jamainternmed.2020.8168 Abstract Importance During the coronavirus disease 2019 (COVID-19) pandemic, the general public has been advi...

ORIGINAL ARTICLE A Novel Circulating MicroRNA for the Detection of Acute Myocarditis Rafael Blanco-Domínguez, Raquel Sánchez-Díaz, Hortensia de la Fuente, et al N Engl J Med 2021; 384:2014-2027DOI: 10.1056/NEJMoa2003608 Abstract BACKGROUND The diagnosis of acute myocarditis typically requires either endomyocardial biopsy (which is invasive) or cardiovascular magnetic resonance imaging (which is not universally available). Additional approaches to diagnos...

ORIGINAL ARTICLE Antibiotic Therapy for 6 or 12 Weeks for Prosthetic Joint Infection Louis Bernard, Cédric Arvieux, Benoit Brunschweiler, et al N Engl J Med 2021; 384:1991-2001DOI: 10.1056/NEJMoa2020198 Abstract BACKGROUND The management of prosthetic joint infection usually consists of a combination of surgery and antimicrobial therapy. The appropriate duration of antimicrobial therapy for this indication remains unclear. METHODS We performed...

ONLINE FIRST (FREE ACCESS)  Dekeyser T. et al. ~Combined psychologist-physician post-death meeting as part of an integrated bereavement program for families Metnitz P.G.H. et al. ~ Evaluation and calibration of SAPS 3 in patients with COVID-19 admitted to intensive care units Du M. et al. ~Integrative omics provide biological and clinical insights into acute respiratory distress syndrome Dallmeier K. et al. ~ COVID-19 and the...