ONLINE FIRST THIS WEEK(FREE ACCESS) Letter ~ Rousset D. et al. - Bedside ultrasound monitoring of prone position induced lung inflationCOVID-19 in Intensive Care ~ Sandroni C. et al. ~The impact of COVID-19 on the epidemiology, outcome and management of cardiac arrestConference Reports and Expert Panel ~ Domínguez-Gil B. et al. - Expanding controlled donation after the circulatory determination of death: statement from an international collaborativeCOVID-19 in Intensiv...

Research Letter March 1, 2021 Binding and Neutralization Antibody Titers After a Single Vaccine Dose in Health Care Workers Previously Infected With SARS-CoV-2 Saman Saadat, Zahra Rikhtegaran Tehrani, James Logue, et al JAMA. Published online March 1, 2021. doi:10.1001/jama.2021.3341 Current shortages in COVID-19 vaccine production and distribution have led some experts to suggest untested regimens.1 Persons who have had COVID-19 are thought to ...

Original Investigation February 26, 2021 Association of Convalescent Plasma Treatment With Clinical Outcomes in Patients With COVID-19: A Systematic Review and Meta-analysis Perrine Janiaud, Cathrine Axfors, MD, Andreas M. Schmitt, et al JAMA. Published online February 26, 2021. doi:10.1001/jama.2021.2747 Abstract Importance Convalescent plasma is a proposed treatment for COVID-19. Objective To assess clinical outcomes with convalesc...

Original Investigation February 17, 2021 Effect of a Single High Dose of Vitamin D3 on Hospital Length of Stay in Patients With Moderate to Severe COVID-19: A Randomized Clinical Trial Igor H. Murai, Alan L. Fernandes, Lucas P. Sales, et al JAMA. Published online February 17, 2021. doi:10.1001/jama.2020.26848 Abstract Importance The efficacy of vitamin D3 supplementation in coronavirus disease 2...

ORIGINAL ARTICLE A Neutralizing Monoclonal Antibody for Hospitalized Patients with Covid-19 ACTIV-3/TICO LY-CoV555 Study Group N Engl J Med 2021; 384:905-914DOI: 10.1056/NEJMoa2033130 Abstract BACKGROUND LY-CoV555, a neutralizing monoclonal antibody, has been associated with a decrease in viral load and the frequency of hospitalizations or emergency department visits among outpatients with coronavirus disease 2019 (Covid-19). Data are needed on the effec...

Original Investigation February 23, 2021 Effect of High-Dose Baclofen on Agitation-Related Events Among Patients With Unhealthy Alcohol Use Receiving Mechanical Ventilation: A Randomized Clinical Trial Mickael Vourc’h, Charlotte Garret, Arnaud Gacouin, et al JAMA. 2021;325(8):732-741. doi:10.1001/jama.2021.0658 Abstract Importance Unhealthy alcohol use can lead to agitation in the intensive care unit (ICU). Objective To assess whethe...

Research Early initiation of prophylactic anticoagulation for prevention of coronavirus disease 2019 mortality in patients admitted to hospital in the United States: cohort study Christopher T Rentsch, Joshua A Beckman, Laurie Tomlinson, et al BMJ 2021; 372: n311 doi: https://doi.org/10.1136/bmj.n311 (Published 11 February 2021) Abstract Objective To evaluate whether early initiation of prophylactic anticoagulation compared with ...

ORIGINAL ARTICLE Terlipressin plus Albumin for the Treatment of Type 1 Hepatorenal Syndrome Florence Wong, S. Chris Pappas, Michael P. Curry, et al N Engl J Med 2021; 384:818-828DOI: 10.1056/NEJMoa2008290 Abstract BACKGROUND The vasoconstrictor terlipressin is used for type 1 hepatorenal syndrome (HRS-1) in many parts of the world and is part of the clinical practice guidelines in Europe. METHODS We conducted a phase 3 trial to confirm the efficacy...

Original Investigation January 21, 2021 Effect of Bamlanivimab as Monotherapy or in Combination With Etesevimab on Viral Load in Patients With Mild to Moderate COVID-19: A Randomized Clinical Trial Robert L. Gottlieb, Ajay Nirula, Peter Chen, et al JAMA. 2021;325(7):632-644. doi:10.1001/jama.2021.0202 Abstract Importance Coronavirus disease 2019 (COVID-19) continues to spread rapidly worldwide. Neutralizing antibodies are a potential treatment for C...

ORIGINAL ARTICLE A Randomized Trial of Albumin Infusions in Hospitalized Patients with Cirrhosis Louise China, Nick Freemantle, Ewan Forrest, et al N Engl J Med 2021; 384:808-817 Abstract BACKGROUND Infection and increased systemic inflammation cause organ dysfunction and death in patients with decompensated cirrhosis. Preclinical studies provide support for an antiinflammatory role of albumin, but confirmatory large-scale clinical trials are lacking. Wh...