ICU Management & Practice, Volume 21 - Issue 3, 2021 New Applications of Pulse Oximetry The clinical applications of pulse oximetry go far beyond the mere monitoring of SpO2. From home to ICUs, pulse oximeters may help to improve quality of care in patients with respiratory and circulatory disorders, in particular those with the coronavirus disease 2019 (COVID-19).Pulse oximetry was developed in the 1970’s to monitor oxygen saturation (SpO2) during anaesthe...

ARTICLES| VOLUME 9, ISSUE 8, P851-862, AUGUST 01, 2021 Extracorporeal membrane oxygenation network organisation and clinical outcomes during the COVID-19 pandemic in Greater Paris, France: a multicentre cohort study Guillaume Lebreton, Matthieu Schmidt, Maharajah Ponnaiah, et al Lancet Respir Med 2021; 9: 851-862 DOI:https://doi.org/10.1016/S2213-2600(21)00096-5 Summary Background In the Île-de-France region (henceforth termed Greater P...

ORIGINAL ARTICLE Immediate versus Postponed Intervention for Infected Necrotizing Pancreatitis Lotte Boxhoorn, Sven M. van Dijk, Janneke van Grinsven, et al N Engl J Med 2021; 385:1372-1381DOI: 10.1056/NEJMoa2100826 Abstract BACKGROUND Infected necrotizing pancreatitis is a potentially lethal disease that is treated with the use of a step-up approach, with catheter drainage often delayed until the infected necrosis is encapsulated. Whether outcomes could...

ARTICLES|ONLINE FIRST Cyclophosphamide added to glucocorticoids in acute exacerbation of idiopathic pulmonary fibrosis (EXAFIP): a randomised, double-blind, placebo-controlled, phase 3 trial Jean-Marc Naccache, Stéphane Jouneau, Morgane Didier, et al Lancet Respir Med Published:September 07, 2021 DOI:https://doi.org/10.1016/S2213-2600(21)00354-4 Summary Background The use of cyclophosphamide in patients with acute exacerbation of idiopathic pulmonary ...

ARTICLES|ONLINE FIRST Awake prone positioning for COVID-19 acute hypoxaemic respiratory failure: a randomised, controlled, multinational, open-label meta-trial Stephan Ehrmann, Jie Li, Miguel Ibarra-Estrada, et al Lancet Respir Med Published:August 20, 2021 DOI:https://doi.org/10.1016/S2213-2600(21)00356-8 Summary Background Awake prone positioning has been reported to improve oxygenation for patients with COVID-19 in retrospective and observational s...

ARTICLES | ONLINE FIRST Inhaled isoflurane via the anaesthetic conserving device versus propofol for sedation of invasively ventilated patients in intensive care units in Germany and Slovenia: an open-label, phase 3, randomised controlled, non-inferiority trial Andreas Meiser, Thomas Volk, Jan Wallenborn, et al Lancet Respir Med Published:August 26, 2021 DOI:https://doi.org/10.1016/S2213-2600(21)00323-4 Summary Background Previous studies indicate tha...

ARTICLES|ONLINE FIRST Daily testing for contacts of individuals with SARS-CoV-2 infection and attendance and SARS-CoV-2 transmission in English secondary schools and colleges: an open-label, cluster-randomised trial Bernadette C Young, David W Eyre, Saroj Kendrick, et al Lancet Published:September 14, 2021 DOI:https://doi.org/10.1016/S0140-6736(21)01908-5 Summary Background School-based COVID-19 contacts in England have been asked to self-isolate at home...

Original Investigation September 21, 2021 Effect of Probiotics on Incident Ventilator-Associated Pneumonia in Critically Ill Patients: A Randomized Clinical Trial Jennie Johnstone, Maureen Meade, François Lauzier, et al JAMA. 2021;326(11):1024-1033. doi:10.1001/jama.2021.13355 Abstract Importance  Growing interest in microbial dysbiosis during critical illness has raised questions about the therapeutic potential of microbiome modifi...

ONLINE FIRST (FREE ACCESS) OriginalsManagement of arterial partial pressure of carbon dioxide in the first week after traumatic brain injury: results from the CENTER-TBI studyCiterio G. et al.Occurrence and timing of withdrawal of life-sustaining measures in traumatic brain injury patients: a CENTER-TBI studyvan Veen E. et al. Correspondances“L’histoire se répète”, one size does not fit allKuindersma M. and Spronk P.E.“L'histoire se répète”, one size does not fi...

ORIGINAL ARTICLE Protection of BNT162b2 Vaccine Booster against Covid-19 in Israel Yinon M. Bar-On, Yair Goldberg, Micha Mandel, et al N Engl J Med September 15, 2021DOI: 10.1056/NEJMoa2114255 Abstract BACKGROUND On July 30, 2021, the administration of a third (booster) dose of the BNT162b2 messenger RNA vaccine (Pfizer–BioNTech) was approved in Israel for persons who were 60 years of age or older and who had received a second dose of vaccine at lea...