ORIGINAL ARTICLEFREE PREVIEW Hypothermia versus Normothermia after Out-of-Hospital Cardiac Arrest Josef Dankiewicz, Tobias Cronberg, Gisela Lilja, et al N Engl J Med 2021; 384:2283-2294DOI: 10.1056/NEJMoa2100591 Abstract BACKGROUND Targeted temperature management is recommended for patients after cardiac arrest, but the supporting evidence is of low certainty. METHODS In an open-label trial with blinded assessment of outcomes, we randomly assigned ...

ONLINE FIRST THIS WEEK(FREE ACCESS) Tanios M. et al. ~Fentanyl- and midazolam-induced coma each influence days of mechanical ventilation and 28-day mortality Kalbhenn J. et al. ~ “Do no further harm” – Why shall we sedate unresponsive patients? Vaara S.T. et al. ~Restrictive fluid management versus usual care in acute kidney injury (REVERSE-AKI): a pilot randomized controlled feasibility trial Patel B.V. et al. ~ Natural history, trajectory...

ARTICLES| VOLUME 397, ISSUE 10288, P1885-1894, MAY 22, 2021 Patient care and clinical outcomes for patients with COVID-19 infection admitted to African high-care or intensive care units (ACCCOS): a multicentre, prospective, observational cohort study The African COVID-19 Critical Care Outcomes Study (ACCCOS) Investigators Lancet 2021; 397: 1885-1894 DOI:https://doi.org/10.1016/S0140-6736(21)00441-4 Summary Background There have been ins...

CORRESPONDENCE PF4 Immunoassays in Vaccine-Induced Thrombotic Thrombocytopenia N Engl J Med May 19, 2021DOI: 10.1056/NEJMc2106383 TO THE EDITOR: In a recent study, Greinacher et al.1 reported thrombotic complications, mostly cerebral vein thrombosis, associated with thrombocytopenia in 11 patients after they had been vaccinated with ChAdOx1 nCoV-19 (AstraZeneca). Although none of these patients had received heparin, the authors detected high titers of anti–pla...

ARTICLES|ONLINE FIRST Effects of nurse-to-patient ratio legislation on nurse staffing and patient mortality, readmissions, and length of stay: a prospective study in a panel of hospitals Matthew D McHugh, Linda H Aiken, Douglas M Sloane, et al Lancet Published: May 11, 2021 DOI:https://doi.org/10.1016/S0140-6736(21)00768-6 Summary Background Substantial evidence indicates that patient outcomes are more favourable in hospitals with better nurse staffin...

ARTICLES| VOLUME 397, ISSUE 10291, P2253-2263, JUNE 12, 2021 Therapeutic versus prophylactic anticoagulation for patients admitted to hospital with COVID-19 and elevated D-dimer concentration (ACTION): an open-label, multicentre, randomised, controlled trial Renato D Lopes, Pedro Gabriel Melo de Barros e Silva, Remo H M Furtado, et al Lancet 2021; 397: 2253-2263 DOI:https://doi.org/10.1016/S0140-6736(21)01203-4 Summary Background C...

Research Letter May 6, 2021 Asymptomatic and Symptomatic SARS-CoV-2 Infections After BNT162b2 Vaccination in a Routinely Screened Workforce Li Tang, Diego R. Hijano, Aditya H. Gaur, et al JAMA. Published online May 6, 2021. doi:10.1001/jama.2021.6564 A 2-dose regimen of the BNT162b2 vaccine (Pfizer-BioNTech) against SARS-CoV-2 was authorized in December 2020 based on reported 94.8% efficacy.1 Although an association between vaccination and a red...

Original Investigation May 11, 2021 Effect of a Digital Intervention on Depressive Symptoms in Patients With Comorbid Hypertension or Diabetes in Brazil and Peru: Two Randomized Clinical Trials Ricardo Araya, Paulo Rossi Menezes, Heloísa Garcia Claro, et al JAMA. 2021;325(18):1852-1862. doi:10.1001/jama.2021.4348 Abstract Importance  Depression is a leading contributor to disease burden globally. Digital mental health interventions ...

Original Investigation May 11, 2021 Effect of Antimicrobial Therapy on Respiratory Hospitalization or Death in Adults With Idiopathic Pulmonary Fibrosis: The CleanUP-IPF Randomized Clinical Trial Fernando J. Martinez, Eric Yow, Kevin R. Flaherty, et al JAMA. 2021;325(18):1841-1851. doi:10.1001/jama.2021.4956 Abstract Importance Alteration in lung microbes is associated with disease progression in idiopathic pulmonary fibrosis. Objective...

Research Prophylaxis against covid-19: living systematic review and network meta-analysis Jessica J Bartoszko, Reed A C Siemieniuk,  Elena Kum, et al BMJ 2021; 373 doi: https://doi.org/10.1136/bmj.n949 (Published 26 April 2021)Cite this as: BMJ 2021;373:n949 Abstract Objective To determine and compare the effects of drug prophylaxis on SARS-CoV-2 infection and covid-19. Design Living systematic review and network meta-analysis. Data sources W...