Individualised versus conventional glucose control in critically-ill patients: the CONTROLING study—a randomized clinical trial Julien Bohé, Hassane Abidi, Vincent Brunot, et al Intensive Care Med Published: 29 September 2021 Abstract Purpose Hyperglycaemia is an adaptive response to stress commonly observed in critical illness. Its management remains debated in the intensive care unit (ICU). Individualising hyperglycaemia management, by targeting the patie...

Effect of oral chlorhexidine de-adoption and implementation of an oral care bundle on mortality for mechanically ventilated patients in the intensive care unit (CHORAL): a multi-center stepped wedge cluster-randomized controlled trial Craig M. Dale, Louise Rose, Sarah Carbone, et al Intensive Care Med Published: 05 October 2021 Abstract Purpose Oral chlorhexidine is used widely for mechanically ventilated patients to prevent pneumonia, but recent studies sh...

ONLINE FIRST (FREE ACCESS) LATEST ARTICLES OPEN ACCESS ~ OriginalRole of total lung stress on the progression of early COVID-19 pneumoniaCoppola S. et al. Conference Reports and Expert PanelCritically ill cancer patient’s resuscitation: a Belgian/French societies’ consensus conferenceMeert A-P. et al.  EditorialThe goal of personalized glucose control in the critically ill remains elusiveKrinsley J.S., Deane A.M. and Gunst J. Imaging in Intensive Care Medic...

Original Investigation Caring for the Critically Ill PatientOctober 4, 2021 Effect of Convalescent Plasma on Organ Support–Free Days in Critically Ill Patients With COVID-19: A Randomized Clinical Trial Writing Committee for the REMAP-CAP Investigators JAMA. Published online October 4, 2021. doi:10.1001/jama.2021.18178 Abstract Importance  The evidence for benefit of convalescent plasma for critically ill patients with COVID-19 is i...

Original Investigation October 5, 2021 Effect of a Pulmonary Embolism Diagnostic Strategy on Clinical Outcomes in Patients Hospitalized for COPD Exacerbation: A Randomized Clinical Trial David Jiménez, Alvar Agustí, Eva Tabernero, et al JAMA. 2021;326(13):1277-1285. doi:10.1001/jama.2021.14846 Abstract Importance  Active search for pulmonary embolism (PE) may improve outcomes in patients hospitalized for exacerbations of chronic obs...

Original Investigation Caring for the Critically Ill PatientOctober 5, 2021 Effect of Prophylactic Subcutaneous Scopolamine Butylbromide on Death Rattle in Patients at the End of Life: The SILENCE Randomized Clinical Trial Harriëtte J. van Esch, Lia van Zuylen, Eric C. T. Geijteman, et al JAMA. 2021;326(13):1268-1276. doi:10.1001/jama.2021.14785 Abstract Importance  Death rattle, defined as noisy breathing caused by the presence of ...

Original Investigation September 29, 2021 Effect of Vasopressin and Methylprednisolone vs Placebo on Return of Spontaneous Circulation in Patients With In-Hospital Cardiac Arrest: A Randomized Clinical Trial Lars W. Andersen, Dan Isbye, Jesper Kjærgaard, et al JAMA. Published online September 29, 2021. doi:10.1001/jama.2021.16628 Abstract Importance  Previous trials have suggested that vasopressin and methylprednisolone administered...

Original Investigation Caring for the Critically Ill PatientOctober 21, 2021 Effect of 12 mg vs 6 mg of Dexamethasone on the Number of Days Alive Without Life Support in Adults With COVID-19 and Severe Hypoxemia: The COVID STEROID 2 Randomized Trial The COVID STEROID 2 Trial Group JAMA. Published online October 21, 2021. doi:10.1001/jama.2021.18295 Abstract Importance  A daily dose with 6 mg of dexamethasone is recommended for up to...

Research Procalcitonin and lung ultrasonography point-of-care testing to determine antibiotic prescription in patients with lower respiratory tract infection in primary care: pragmatic cluster randomised trial Loïc Lhopitallier, Andreas Kronenberg, Jean-Yves Meuwly, et al BMJ 2021; 374 doi: https://doi.org/10.1136/bmj.n2132 (Published 21 September 2021)Cite this as: BMJ 2021;374:n2132 Abstract Objective To assess whether point-of care procalcitonin and...

ICU Management & Practice, Volume 21 - Issue 2, 2021 If It’s Good for Calcium Why Not Magnesium? Reasons to Measure iMg in the ICU An overview of the importance of getting magnesium levels right in critically ill patients and the role ionised magnesium plays. Background Like all electrolytes, magnesium exists in the bloodstream in “bound” states, and in “free” or “ionised” states, which is the portion that is physiologically active. This ionised compo...