ORIGINAL ARTICLE Early Treatment for Covid-19 with SARS-CoV-2 Neutralizing Antibody Sotrovimab Anil Gupta, Yaneicy Gonzalez-Rojas, Erick Juarez, et al N Engl J Med October 27, 2021DOI: 10.1056/NEJMoa2107934 Abstract BACKGROUND Coronavirus disease 2019 (Covid-19) disproportionately results in hospitalization or death in older patients and those with underlying conditions. Sotrovimab is a pan-sarbecovirus monoclonal antibody that was designed to preve...

ICU Management & Practice, Volume 21 - Issue 3, 2021 Vasopressor Management in Septic Shock: General Overview and Personalised Approaches This article summarises the proceedings of an ESICM webinar in which two experts discuss vasopressor therapy and its fundamental role in the treatment of septic shock-induced hypotension. They provide an overview of severe septic shock, the benefits of second-line vasopressors and their use in COVID-19 patients....

Original Investigation October 11, 2021 Effect of Antithrombotic Therapy on Clinical Outcomes in Outpatients With Clinically Stable Symptomatic COVID-19: The ACTIV-4B Randomized Clinical Trial Jean M. Connors, Maria M. Brooks, Frank C. Sciurba, et al JAMA. Published online October 11, 2021. doi:10.1001/jama.2021.17272 Abstract Importance  Acutely ill inpatients with COVID-19 typically receive antithromb...

Original Investigation October 19, 2021 Effect of Moderate vs Mild Therapeutic Hypothermia on Mortality and Neurologic Outcomes in Comatose Survivors of Out-of-Hospital Cardiac Arrest: The CAPITAL CHILL Randomized Clinical Trial Michel Le May, Christina Osborne, Juan Russo, et al JAMA. 2021;326(15):1494-1503. doi:10.1001/jama.2021.15703 Abstract Importance  Comatose survivors of out-of-hospital cardiac arrest experience high rates o...

ONLINE FIRST (FREE ACCESS) LATEST ARTICLES OPEN ACCESS ~ OriginalsVariation in severity-adjusted resource use and outcome in intensive care unitsTakala J. et al. OriginalAerobic exercise capacity in long-term survivors of critical illness: secondary analysis of the post-EPaNIC follow-up studyVan Aerde N. et al. Systematic ReviewPalliative care interventions in intensive care unit patientsMetaxa V. et al. OPEN ACCESS ~ Systematic ReviewEffect of adjunctive v...

High dose coupled plasma filtration and adsorption in septic shock patients. Results of the COMPACT-2: a multicentre, adaptive, randomised clinical trial Elena Garbero, Sergio Livigni, Fiorenza Ferrari, et al Intensive Care Med Published: 03 October 2021 Abstract Purpose This study aimed at evaluating the efficacy and safety of high-dose (> 0.2 L/kg of treated plasma per day) coupled plasma filtration-adsorption (CPFA) in treating patients with septic sh...

Why Intensivists Should Participate in Home Ventilation Teams A historical review of the birth of intensive care medicine and home mechanical ventilation; and an opinion piece on the merits of intensivists participating in home ventilation care teams. The world is currently reeling from the ravages of COVID-19. It is still too early to know how healthcare will be transformed as a result of this epidemic. For now, it appears that COVID-19 will leave behind large numb...

Original Investigation October 7, 2021 Association of Receipt of the Ad26.COV2.S COVID-19 Vaccine With Presumptive Guillain-Barré Syndrome, February-July 2021 Emily Jane Woo, Adamma Mba-Jonas, Rositsa B. Dimova, et al JAMA. Published online October 7, 2021. doi:10.1001/jama.2021.16496 Abstract Importance  As part of postauthorization safety surveillance, the US Food and Drug Administration (FDA) ha...

Original Investigation October 11, 2021 Effect of Antithrombotic Therapy on Clinical Outcomes in Outpatients With Clinically Stable Symptomatic COVID-19: The ACTIV-4B Randomized Clinical Trial Jean M. Connors, Maria M. Brooks, Frank C. Sciurba, et al JAMA. Published online October 11, 2021. doi:10.1001/jama.2021.17272 Abstract Importance  Acutely ill inpatients with COVID-19 typically receive antithrombotic therapy, although the ris...

Original Investigation September 3, 2021 Surveillance for Adverse Events After COVID-19 mRNA Vaccination Nicola P. Klein, Ned Lewis, Kristin Goddard, et al JAMA. 2021;326(14):1390-1399. doi:10.1001/jama.2021.15072 Abstract Importance  Safety surveillance of vaccines against COVID-19 is critical to ensure safety, maintain trust, and inform policy. Objectives  To monitor 23 serious outcomes weekly, using comprehensive health record...