Original Investigation Caring for the Critically Ill Patient Effect of Low-Normal vs High-Normal Oxygenation Targets on Organ Dysfunction in Critically Ill Patients: A Randomized Clinical Trial Harry Gelissen, Harm-Jan de Grooth, Yvo Smulders, et al JAMA. Published online August 31, 2021. doi:10.1001/jama.2021.13011 Abstract Importance  Hyperoxemia may increase organ dysfunction in critically ill patients, but optimal oxygenation targets are unkno...

Original Investigation August 3, 2021 Effect of a Sedation and Ventilator Liberation Protocol vs Usual Care on Duration of Invasive Mechanical Ventilation in Pediatric Intensive Care Units: A Randomized Clinical Trial Bronagh Blackwood, Lyvonne N. Tume, Kevin P. Morris, et al JAMA. 2021;326(5):401-410. doi:10.1001/jama.2021.10296 Abstract Importance  There is limited evidence on the optimal strategy for liberating infants and childr...

ORIGINAL ARTICLE Covid-19 Breakthrough Infections in Vaccinated Health Care Workers Moriah Bergwerk, Tal Gonen, Yaniv Lustig, et al N Engl J Med July 28, 2021DOI: 10.1056/NEJMoa2109072 Abstract BACKGROUND Despite the high efficacy of the BNT162b2 messenger RNA vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), rare breakthrough infections have been reported, including infections among health care workers. Data are needed t...

Research Real time remote symptom monitoring during chemotherapy for cancer: European multicentre randomised controlled trial (eSMART) Roma Maguire, Lisa McCann, Grigorios Kotronoulas, et al BMJ 2021; 374 doi: https://doi.org/10.1136/bmj.n1647 (Published 22 July 2021) Cite this as: BMJ 2021;374:n1647 Abstract Objective To evaluate effects of remote monitoring of adjuvant chemotherapy related side effects via the Advanced Symptom Management System (A...

Original Investigation July 27, 2021 Effect of 7 vs 14 Days of Antibiotic Therapy on Resolution of Symptoms Among Afebrile Men With Urinary Tract Infection: A Randomized Clinical Trial Dimitri M. Drekonja, Barbara Trautner, Carla Amundson, et al JAMA. 2021;326(4):324-331. doi:10.1001/jama.2021.9899 Abstract Importance  Determination of optimal treatment durations for common infectious diseases is an important strategy to preserve an...

Original Investigation July 27, 2021 Effect of a Hospital and Postdischarge Quality Improvement Intervention on Clinical Outcomes and Quality of Care for Patients With Heart Failure With Reduced Ejection Fraction: The CONNECT-HF Randomized Clinical Trial Adam D. DeVore, Bradi B. Granger, Gregg C. Fonarow, et al JAMA. 2021;326(4):314-323. doi:10.1001/jama.2021.8844 Abstract Importance  Adoption of guideline-directed medical therapy for patient...

ICU Management & Practice, Volume 21 - Issue 2, 2021 Intensive Care Physiotherapists Should be Using Point of Care Ultrasound (POCUS) An overview of the potential of POCUS on clinical decision making at the bedside and the need to add it as a new diagnostic tool by intensive care physiotherapists. Introduction Intensive care physiotherapists often rely on standard assessment tools, such as measures of physiological function (arterial blood gases)...

ORIGINAL ARTICLE Abelacimab for Prevention of Venous Thromboembolism Peter Verhamme, B. Alexander Yi, Annelise Segers, et al N Engl J Med July 19, 2021DOI: 10.1056/NEJMoa2105872 Abstract BACKGROUND The role of factor XI in the pathogenesis of postoperative venous thromboembolism is uncertain. Abelacimab is a monoclonal antibody that binds to factor XI and locks it in the zymogen (inactive precursor) conformation. METHODS In this open-label, paralle...

Original Investigation July 16, 2021 Effect of Oral Azithromycin vs Placebo on COVID-19 Symptoms in Outpatients With SARS-CoV-2 Infection: A Randomized Clinical Trial Catherine E. Oldenburg, Benjamin A. Pinsky, Jessica Brogdon, et al JAMA. Published online July 16, 2021. doi:10.1001/jama.2021.11517 Abstract Importance  Azithromycin has been hypothesized to have activity against SARS-CoV-2. Objective  To determine whethe...

Original Investigation August 10, 2021 Effect of Slower vs Faster Intravenous Fluid Bolus Rates on Mortality in Critically Ill Patients: The BaSICS Randomized Clinical Trial Fernando G. Zampieri, Flávia R. Machado, Rodrigo S. Biondi, et al JAMA. Published online August 10, 2021. doi:10.1001/jama.2021.11444 Abstract Importance  Slower intravenous fluid infusion rates could reduce the formation of tissue edema and organ dysfunction in...