ARTICLES| VOLUME 21, ISSUE 9, P1233-1245, SEPTEMBER 01, 2021 Diagnostic performance of different sampling approaches for SARS-CoV-2 RT-PCR testing: a systematic review and meta-analysis Nicole Ngai Yung Tsang, Hau Chi So, Ka Yan Ng, et al Lancet Infect Dis 2021; 21: 1233-1245 DOI:https://doi.org/10.1016/S1473-3099(21)00146-8 Summary Background The comparative performance of different clinical sampling methods for diagnosis of SARS-CoV-2...

ICU Management & Practice, Volume 21 - Issue 2, 2021 The Essentials for a Humanised Intensive Care Unit (H-ICU) This article highlights the key points that fall under the meaning of humanisation as part of the ICU Liberation bundle. Introduction How would a patient describe their stay inside an Intensive Care Unit (ICU)? Would it be cold, lonely, a place full of uncertainty? Painful, uncomfortable or scary? The length of stay (LOS) in the ICU may be t...

ARTICLES| VOLUME 21, ISSUE 9, P1313-1323, SEPTEMBER 01, 2021 Efficacy and safety of suvratoxumab for prevention of Staphylococcus aureus ventilator-associated pneumonia (SAATELLITE): a multicentre, randomised, double-blind, placebo-controlled, parallel-group, phase 2 pilot trial Bruno François, Hasan S Jafri, Jean Chastre, et al Lancet Infect Dis 2021; 21: 1313-1323 DOI:https://doi.org/10.1016/S1473-3099(20)30995-6 Summary Background St...

ICU Management & Practice, Volume 21 - Issue 3, 2021 Practical Strategies in Mechanical Ventilation for Patients With COVID-19 Acute Respiratory Failure COVID-19 represents a challenge in respiratory therapy. Evidence-guided protective mechanical ventilation is essential to reduce mortality.“Only a set of well-directed strategies can combat a formidable enemy.” Introduction The SARS-CoV-2 virus responsible for the COVID-19 pandemic has a wide variety ...

ARTICLES| VOLUME 9, ISSUE 9, P957-968, SEPTEMBER 01, 2021 Imatinib in patients with severe COVID-19: a randomised, double-blind, placebo-controlled, clinical trial Jurjan Aman, Erik Duijvelaar, Liza Botros, et al Lancet Respir Med 2021; 9: 957-968 DOI:https://doi.org/10.1016/S2213-2600(21)00237-X Summary Background The major complication of COVID-19 is hypoxaemic respiratory failure from capillary leak and alveolar oedema. Experimental ...

ICU Management & Practice, Volume 21 - Issue 3, 2021 Apnoeic Oxygenation for Intubation - Where is the Evidence? Apnoeic oxygenation can be used in critically ill patients, without replacing preoxygenation. Introduction Hypoxaemia is one of the most common complications during tracheal intubation of critically ill patients (Jaber et al. 2006; Russotto et al. 2021) with an incidence of severe hypoxaemia reaching up to 50% (De Jong et al. 2013; Jaber et...

ARTICLES| VOLUME 9, ISSUE 9, P989-998, SEPTEMBER 01, 2021 Clinical characteristics and outcomes of invasively ventilated patients with COVID-19 in Argentina (SATICOVID): a prospective, multicentre cohort study Elisa Estenssoro, Cecilia I Loudet, Fernando G Ríos, et al Lancet Respir Med 2021; 9: 989-998 DOI:https://doi.org/10.1016/S2213-2600(21)00229-0 Summary Background Although COVID-19 has greatly affected many low-income and mid...

ICU Management & Practice, Volume 21 - Issue 3, 2021 New Applications of Pulse Oximetry The clinical applications of pulse oximetry go far beyond the mere monitoring of SpO2. From home to ICUs, pulse oximeters may help to improve quality of care in patients with respiratory and circulatory disorders, in particular those with the coronavirus disease 2019 (COVID-19).Pulse oximetry was developed in the 1970’s to monitor oxygen saturation (SpO2) during anaesthe...

ARTICLES| VOLUME 9, ISSUE 8, P851-862, AUGUST 01, 2021 Extracorporeal membrane oxygenation network organisation and clinical outcomes during the COVID-19 pandemic in Greater Paris, France: a multicentre cohort study Guillaume Lebreton, Matthieu Schmidt, Maharajah Ponnaiah, et al Lancet Respir Med 2021; 9: 851-862 DOI:https://doi.org/10.1016/S2213-2600(21)00096-5 Summary Background In the Île-de-France region (henceforth termed Greater P...

ORIGINAL ARTICLE Immediate versus Postponed Intervention for Infected Necrotizing Pancreatitis Lotte Boxhoorn, Sven M. van Dijk, Janneke van Grinsven, et al N Engl J Med 2021; 385:1372-1381DOI: 10.1056/NEJMoa2100826 Abstract BACKGROUND Infected necrotizing pancreatitis is a potentially lethal disease that is treated with the use of a step-up approach, with catheter drainage often delayed until the infected necrosis is encapsulated. Whether outcomes could...