Original Investigation October 19, 2021 Effect of Moderate vs Mild Therapeutic Hypothermia on Mortality and Neurologic Outcomes in Comatose Survivors of Out-of-Hospital Cardiac Arrest: The CAPITAL CHILL Randomized Clinical Trial Michel Le May, Christina Osborne, Juan Russo, et al JAMA. 2021;326(15):1494-1503. doi:10.1001/jama.2021.15703 Abstract Importance  Comatose survivors of out-of-hospital cardiac arrest experience high rates o...

ONLINE FIRST (FREE ACCESS) LATEST ARTICLES OPEN ACCESS ~ OriginalsVariation in severity-adjusted resource use and outcome in intensive care unitsTakala J. et al. OriginalAerobic exercise capacity in long-term survivors of critical illness: secondary analysis of the post-EPaNIC follow-up studyVan Aerde N. et al. Systematic ReviewPalliative care interventions in intensive care unit patientsMetaxa V. et al. OPEN ACCESS ~ Systematic ReviewEffect of adjunctive v...

High dose coupled plasma filtration and adsorption in septic shock patients. Results of the COMPACT-2: a multicentre, adaptive, randomised clinical trial Elena Garbero, Sergio Livigni, Fiorenza Ferrari, et al Intensive Care Med Published: 03 October 2021 Abstract Purpose This study aimed at evaluating the efficacy and safety of high-dose (> 0.2 L/kg of treated plasma per day) coupled plasma filtration-adsorption (CPFA) in treating patients with septic sh...

Why Intensivists Should Participate in Home Ventilation Teams A historical review of the birth of intensive care medicine and home mechanical ventilation; and an opinion piece on the merits of intensivists participating in home ventilation care teams. The world is currently reeling from the ravages of COVID-19. It is still too early to know how healthcare will be transformed as a result of this epidemic. For now, it appears that COVID-19 will leave behind large numb...

Original Investigation October 7, 2021 Association of Receipt of the Ad26.COV2.S COVID-19 Vaccine With Presumptive Guillain-Barré Syndrome, February-July 2021 Emily Jane Woo, Adamma Mba-Jonas, Rositsa B. Dimova, et al JAMA. Published online October 7, 2021. doi:10.1001/jama.2021.16496 Abstract Importance  As part of postauthorization safety surveillance, the US Food and Drug Administration (FDA) ha...

Original Investigation October 11, 2021 Effect of Antithrombotic Therapy on Clinical Outcomes in Outpatients With Clinically Stable Symptomatic COVID-19: The ACTIV-4B Randomized Clinical Trial Jean M. Connors, Maria M. Brooks, Frank C. Sciurba, et al JAMA. Published online October 11, 2021. doi:10.1001/jama.2021.17272 Abstract Importance  Acutely ill inpatients with COVID-19 typically receive antithrombotic therapy, although the ris...

Original Investigation September 3, 2021 Surveillance for Adverse Events After COVID-19 mRNA Vaccination Nicola P. Klein, Ned Lewis, Kristin Goddard, et al JAMA. 2021;326(14):1390-1399. doi:10.1001/jama.2021.15072 Abstract Importance  Safety surveillance of vaccines against COVID-19 is critical to ensure safety, maintain trust, and inform policy. Objectives  To monitor 23 serious outcomes weekly, using comprehensive health record...

Individualised versus conventional glucose control in critically-ill patients: the CONTROLING study—a randomized clinical trial Julien Bohé, Hassane Abidi, Vincent Brunot, et al Intensive Care Med Published: 29 September 2021 Abstract Purpose Hyperglycaemia is an adaptive response to stress commonly observed in critical illness. Its management remains debated in the intensive care unit (ICU). Individualising hyperglycaemia management, by targeting the patie...

Effect of oral chlorhexidine de-adoption and implementation of an oral care bundle on mortality for mechanically ventilated patients in the intensive care unit (CHORAL): a multi-center stepped wedge cluster-randomized controlled trial Craig M. Dale, Louise Rose, Sarah Carbone, et al Intensive Care Med Published: 05 October 2021 Abstract Purpose Oral chlorhexidine is used widely for mechanically ventilated patients to prevent pneumonia, but recent studies sh...

ONLINE FIRST (FREE ACCESS) LATEST ARTICLES OPEN ACCESS ~ OriginalRole of total lung stress on the progression of early COVID-19 pneumoniaCoppola S. et al. Conference Reports and Expert PanelCritically ill cancer patient’s resuscitation: a Belgian/French societies’ consensus conferenceMeert A-P. et al.  EditorialThe goal of personalized glucose control in the critically ill remains elusiveKrinsley J.S., Deane A.M. and Gunst J. Imaging in Intensive Care Medic...