Research Letter December 16, 2021 Antibody Response and Variant Cross-Neutralization After SARS-CoV-2 Breakthrough Infection Timothy A. Bates, Savannah K. McBride, Bradie Winders, et al JAMA. 2022;327(2):179-181. doi:10.1001/jama.2021.22898 Breakthrough infections after vaccination against SARS-CoV-2 are increasingly reported, possibly due to waning of vaccine-induced antibody levels.1 Moreover, emerging variants of concern with diminished susceptibility ...

Original Investigation January 11, 2022 Effect of Anticoagulant Therapy for 6 Weeks vs 3 Months on Recurrence and Bleeding Events in Patients Younger Than 21 Years of Age With Provoked Venous Thromboembolism: The Kids-DOTT Randomized Clinical Trial Neil A. Goldenberg, John M. Kittelson, Thomas C. Abshire, et al JAMA. 2022;327(2):129-137. doi:10.1001/jama.2021.23182 Abstract Importance  Among patients younger than 21 years of age,...

ORIGINAL ARTICLE Molnupiravir for Oral Treatment of Covid-19 in Nonhospitalized Patients Angélica Jayk Bernal, Monica M. Gomes da Silva, Dany B. Musungaie, et al N Engl J Med 2022; 386:509-520DOI: 10.1056/NEJMoa2116044 Abstract BACKGROUND New treatments are needed to reduce the risk of progression of coronavirus disease 2019 (Covid-19). Molnupiravir is an oral, small-molecule antiviral prodrug that is active against severe acute respiratory syndrome coro...

CORRESPONDENCE SARS-CoV-2 Omicron Variant Neutralization in Serum from Vaccinated and Convalescent Persons Annika Rössler, Lydia Riepler, David Bante, et al N Engl J Med January 12, 2022DOI: 10.1056/NEJMc2119236 TO THE EDITOR: During the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, several new viral variants have emerged, leading to the virus becoming more contagious. However, efficient immune escape has not been observed, and vacc...

ORIGINAL ARTICLE Mosquito Net Use in Early Childhood and Survival to Adulthood in Tanzania Günther Fink, Sigilbert Mrema, Salim Abdulla, et al N Engl J Med 2022; 386:428-436DOI: 10.1056/NEJMoa2112524 Abstract BACKGROUND It has been hypothesized that in high-transmission settings, malaria control in early childhood (<5 years of age) might delay the acquisition of functional immunity and shift child deaths from younger to older ages. METHODS We us...

ARTICLE Safety, tolerability and viral kinetics during SARS-CoV-2 human challenge Ben Killingley, Alex Mann, Mariya Kalinova, et al https://www.researchsquare.com/article/rs-1121993/v1 Abstract To establish a novel SARS-CoV-2 human challenge model, 36 volunteers aged 18-29 years without evidence of previous infection or vaccination were inoculated with 10 TCID50 of a wild-type virus (SARS-CoV-2/human/GBR/484861/2020) intranasally. Two participants were excl...

CRITICAL CARE: ORIGINAL RESEARCH| VOLUME 161, ISSUE 1, P97-111, JANUARY 01, 2022 The Usefulness of the Rapid Shallow Breathing Index in Predicting Successful Extubation: A Systematic Review and Meta-analysis Vatsal Trivedi, Dipayan Chaudhuri, Rehman Jinah, et al Chest 2022; 161: 97-111 Background Clinicians use several measures to ascertain whether individual patients will tolerate liberation from mechanical ventilation, including the rapid s...

Original Investigation Caring for the Critically Ill PatientFebruary 1, 2022 Effect of Moderate Hypothermia vs Normothermia on 30-Day Mortality in Patients With Cardiogenic Shock Receiving Venoarterial Extracorporeal Membrane Oxygenation: A Randomized Clinical Trial Bruno Levy, Nicolas Girerd, Julien Amour, et al JAMA. 2022;327(5):442-453. doi:10.1001/jama.2021.24776 Key Points Question  Does early use of moderate hypothermia (33-34...

CRITICAL CARE: ORIGINAL RESEARCH| VOLUME 161, ISSUE 1, P112-120, JANUARY 01, 2022 Antibiotic Timing and Progression to Septic Shock Among Patients in the ED With Suspected Infection Roshan Bisarya, Xing Song, John Salle, et al Chest 2022; 161: 112-120 Background Recent medical society opinions have questioned the use of early antimicrobials in patients with sepsis, but without septic shock. Research Question Is time from ED presentation...

Original Investigation January 10, 2022 Association of a Third Dose of BNT162b2 Vaccine With Incidence of SARS-CoV-2 Infection Among Health Care Workers in Israel Avishay Spitzer, Yoel Angel, Or Marudi, et al JAMA. 2022;327(4):341-349. doi:10.1001/jama.2021.23641 Key Points Question  What is the association between immunization with a third (booster) dose of BNT162b2 vaccine (Pfizer-BioNTech) and the incidence of SARS-CoV-2 infection among im...